PUBLICATIONS
PUBLICATIONS
60. You DG, Park JH. A metabolic switchin the TCA cycle: a regulator of intestinal stem cell fate during tissue regeneration. Signal Transduction and Targeted Therapy 2025;10:327 (Link).
59. Lee J, Choi SW, Park M, Um W, Kwon S, Kim CH, Joo H, You DG, Lee JA, Shin S, Kang H, Ghahari F, Kim J, Park JH. Hematite-embedded mesoporous nanoparticles for ferroptosis-inducing cancer sonoimmunotherapy. Journal of Controlled Release 2025;385:113990 (PMID: 40609835).
58. Park JY, Jung SY, Yoo D, Lee S, Go D, Bui VD, Jung WK, You DG*, Park JH*, Um W*. Stem Cell-Derived Extracellular Vesicles in Skin Antiaging Treatments. ACS Nano 2025;19:25:22504-22527 (PMID: 40527735).
57. Yoo D, Jung SY, Go D, Park JY, You DG, Jung WK, Li Y, Ding J, Park JH, Um W. Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine. Journal of Nanobiotechnology 2025;23:1:1-20 (PMID: 40102934).
56. Song Y*, You DG*, Song SH, Lee J, Joo H, Kim CH, Go D, Jung SY, Li Y, Um W, Park JH. Nanobubble‐Based Acoustical Bursting of Nuclear Membrane for Interleukin‐33 Release Induces Eosinophil‐Mediated Cancer Immunotherapy. Advanced Functional Materials 2024;34:46:2407577 (Link).
55. Song J, Cho MH, Cho H, Song Y, Lee SW, Nam HC, Yoon TH, Shin JC, Hong JS, Kim Y, Ekanayake E, Jeon J, You DG, Im SG, Choi GS, Park JS, Carter BC, Balaj L, Seo AN, Miller MA, Park SY, Kang T, Castro CM, Lee H. Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE. Nature Biotechnology doi.org/10.1038/s41587-024-02426-6 (PMID: 39375445).
54. Sol S, Kim CH, Son S, Lee JA, Kwon S, You DG, Lee J, Kim J, Jo DG, Ko H, Park JH. PEDF-Enriched Extracellular Vesicle for Vessel Normalization to Potentiate Immune Checkpoint Blockade Therapy. Biomaterials Research 2024;28:0068 (PMID: 39355307).
53. You DG*, Jung JM*, Kim CH, An JY, Bui VD, Lee J, Um W, Jo DG, Cho YW, Lee DS, Balaj L, Lee H, Park JH. Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis. ACS Applied Materials & Interfaces 2024;16:29:37698-37706 (PMID: 38980897).
52. Hsia T, You DG, Politis MG, Batool SM, Ekanayake E, Lee H, Carter BS, Balaj L. Rigorous Comparison of Extracellular Vesicle Processing to Enhance Downstream Analysis for Glioblastoma Characterization. Advanced Biology 2024;8:1:2300233 (PMID: 37670402).
51. Hong ST*, You DG*, Jo M, Kim CH, Choi Y, Kim C, Park JH, Kim K, Kwon IC, Ryu JH, Imaging of tumor-associated macrophages using near-infrared fluorophore-conjugated dextran-sulfate nanoparticles. Macromolecular Research 2023;31:1113-1124 (Link).
50. Batool SM, Yekula A, Khanna P, Hsia T, Gamblin AS, Ekanayake E, Escobedo AK, You DG, Castro CM, Im H, Kilic T, Garlin MA, Skog J, Dinulescu DM, Dudley J, Agrawal N, Cheng J, Abtin F, Aberle DR, Chia D, Elashof D, Grognan T, Krysan K, Oh SS, Strom C, Tu M, Wei F, Xian R, Skates SJ, Zhang DY, Trinh T, Watson M, Aft R, Rawal S, Agarwal A, Kesmodel SB, Yang C, Shen C, Hochberg FH, Wong DTW, Patel AA, Papadopoulos N, Bettegowda C, Cote RJ, Srivastava S, Lee H, Carter BS, Balaj L. The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring. Cell Reports Medicine 2023;4:10: 101198 (PMID: 37716353).
49. Hsia T, Small JL, Yekula A, Batool SM, Escobedo AK, Ekanayake E, You DG, Lee H, Carter BS, Balaj L. Systematic review of photodynamic therapy in gliomas. Cancers 2023;15:15: 3918 (PMID: 37568734).
48. Song SH, Ghosh T, You DG, Joo H, Lee J, Lee JA, Kim CH, Jeon J, Shin S, Park JH. Functionally Masked Antibody to Uncouple Immune-Related Toxicities in Checkpoint Blockade Cancer Therapy. ACS Nano 2023;17:11:10065–10077 (PMID: 37184643).
47. Hsia T, Yekula A, Batool SM, Rosenffeld Y, You DG, Weissleder R, Lee H, Carter BS, Balaj L. Glioblastoma-derived extracellular vesicle subpopulations following 5-aminolevulinic acid treatment bear diagnostic implications. Journal of Extracellular Vesicles 2022;11:e12278 (PMID: 36404434).
46. Batool SM, Hsia T, Khanna SK, Gamblin AS, Rosenfeld Y, You DG, Carter BS, Balaj L. Decoding vesicle-based precision oncology in gliomas. Neuro-Oncology Advances 2022;4:S2:ii53-ii60 (PMID: 36380860).
45. Kim CH*, You DG*, Pramod Kumar EK, Han KH, Um W, Lee J, Lee JA, Jung JM, Kang H, Park JH. Self-immolative nanosensitizer for glutathione depletion-assisted sonodynamic therapy. Theranostics 2022;12:17:7465-7475 (PMID: 36438485).
44. Jeon J, You DG, Dey A, Yoon B, Li Y, Park JH, Self-immolative polymer-based chemiluminescent nanoparticles for long-term in vivo imaging of reactive oxygen species. Chemistry of Materials 2022;34:17:7741-7749 (Link).
43. Jeon J, Yoon B, Song SH, Um W, Song Y, Lee J, You DG, An JY, Park JH. Chemiluminescence resonance energy transfer-based immunostimulatory nanoparticles for sonoimmunotherapy. Biomaterials 2022;283:121466 (PMID: 35286853).
42. Nguyen VQ, Um W, An JY, Joo H, Choi YC, Jung JM, Choi JS, You DG, Cho YW, Park JP, Precipitation-mediated PEGylation of plant-derived nanovesicles. Macromolecular Research 2022;30:2:85-89 (Link).
41. You DG*, An JY*, Um W, Jung JM, Oh BH, Nguyen VQ, Jeon J, Lee J, Jo DG, Cho YW, Park JH. Stem cell-derived extracellular vesicle-bearing dermal filler ameliorates the dermis microenvironment by supporting CD301b-expressing macrophages. ACS Nano 2022;16:1:251-260 (PMID: 34957822).
40. An JY, Um W, You DG, Song Y, Lee J, Nguyen VQ, Joo H, Park JH. Gold-installed hyaluronic acid hydrogel for ultrasound-triggered thermal elevation and on-demand cargo release. International Journal of Biological Macromolecules 2021;Part A:193:553-561 (PMID: 34673105).
39. Nguyen VQ*, You DG*, Kwon S, Um W, Oh BH, An JY, Jeon J, Park JH. An anti-DR5 antibody-curcumin conjugate for the enhanced clearance of activated hepatic stellate cells. International Journal of Biological Macromolecules 2021;192:1:1231-1239 (PMID: 34626726).
38. Um W, E. K. Pramod, Song Y, Lee J, An JY, Joo H, You DG, Park JH. Carboxymethyl dextran-based nanocomposites for enhanced chemo-sonodynamic therapy of cancer. Carbohydrate Polymers 2021;273:1:118488 (PMID: 34560935).
37. You DG*, Oh BH*, Nguyen VQ, Lim GT, Um W, Jung JM, Choi JS, Choi YC, Jung YJ, Lee J, Jo DG, Cho YW, Park JH. Vitamin A-coupled stem cell-derived extracellular vesicles regulate the fibrotic cascade by targeting activated hepatic stellate cells in vivo. Journal of Controlled Release 2021;336:10:285-295 (PMID: 34174353)
36. You DG*, Lim GT*, Kwon S, Um W, Oh BH, Song SH, Lee J, Jo DG, Cho, YW, Park JH. Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis. Science Advances 2021;7:eabe0083 (highlighted in Nat. Rev. Rheumatol., PMID: 34078596).
35. Nguyen VQ*, You DG*, Oh BH, Bui VD, An JY, Um W, Park JH. Diselenide-Bearing Liposomes for Intracellular Delivery of a Vitamin C Derivative in Cancer Cells. Macromolecular Research 2021;29:327-330 (Link).
34. Lim GT*, You DG*, Han HS, Lee H, Shin S, Oh BH, Kumar EKP, Um W, Kim CH, Han S, Lee S, Lim S, Yoon HY, Kim K, Kwon IC, Jo DG, Cho YW, Park JH. Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases. Journal of Extracellular Vesicles 2021;10:e12077 (PMID: 33738083).
33. Um W, Kumar EKP, Lee J, Kim CH, You DG, Park JH. Recent Advances in Nanomaterial-based Augmented Sonodynamic Therapy of Cancer. Chemical Communications 2021;57:28542866 (PMID: 33625416).
32. Li Y, Xie J, Um W, You DG, Kwon S, Zhang L, Zhu J, Park JH. Sono/Photodynamic Nanomedicine-Elicited Cancer Immunotherapy. Advanced Functional Materials 2020;31:12;2008061 (Link).
31. Lee J, Kim JH, You DG, Kim S, Um W, Jeon J, Kim CH, Joo H, Yi GR, Park JH. Cavitation-inducible mesoporous silica-titania nanoparticles for cancer sonotheranostics. Advanced Healthcare Materials 2020;9:19:2000877 (PMID: 32893995).
30. Jeon J*, You DG*, Um W, Lee J, Kim CH, Shin S, Kwon S, Park JH. Chemiluninescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics. Science Advances 2020;6:eaaz8400 (PMID: 32637587).
29. Um W, Ko H, You DG, Lim S, Kwak G, Shim MG, Yang S, Lee J, Song Y, Kim K, Park JH. Necroptiosis-inducible polymeric nanobubble for enhanced cancer sonoimmunotherapy. Advanced Materials 2020;32:16:1907953 (selected as the cover feature, PMID: 32125731).
28. Han HS, Lee H, You DG, Nguyen VQ, Song DG, Oh BH, Shin S, Choi JS, Kim JD, Pan CH, Jo DG, Cho YW, Choi KY, Park JH. Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis. Journal of Controlled Release 2020;22:328-336 (PMID: 31981658).
27. Moon SJ*, You DG*, Li Y, Um W, Jung JM, Kim CH, Oh BH, Park JH, Lee DS. pH-Sensitive polymeric micelles as the methotrexate carrier for targeting rheumatoid arthritis. Macromolecular Research 2020;28:99-102 (Link).
26. Kwon S, Ko H, You DG, Kataoka K, Park JH. Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment. Accounts of Chemical Research 2019;52:1771-1782 (highly cited paper; web of science, PMID: 31241894).
25. Choi D, Jeon S, You DG, Um W, Kim JY, Yoon HY, Chang HY, Kim DE, Park JH, Kim H, Kim K. Iodinated echogenic glycol chitosan nanoparticles for X-ray CT/US dual imaging of tumor. Nanotheranostics 2018;2:117-127 (PMID: 29577016).
24. You DG, Yoon HY, Jeon S, Um W, Park JH, Kwon IC, Kim K. Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound. Nano Convergence 2017;4:30 (PMID: 29170724).
23. Um W, Kwon S, You DG, Cha JM, Kim HR, Park JH. Non-thermal acoustic treatment as a safe alternative to thermosensitive liposome-involved hyperthermia for cancer therapy. RSC advances 2017;7:29618-29625 (Link).
22. Heo R*, You DG*, Um W, Park JS, Choi Y, Kwon S, Kim K, Kwon IC, Jo DG, Kang YM, Park JH. Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis. Biomaterials 2017;131:15-26 (PMID: 28371624).
21. Yoon HY, Koo H, Jeon S, You DG, Park JH, Kwon IC, Kim K. Inorganic nanoparticles for image-guided therapy. Bioconjugate Chemistry 2017;28:124-134 (PMID: 27788580).
20. Son S, Kim N, You DG, Yoon HY, Yhee JY, Kim K, Kwon IC, Kim SH. Antitumor therapeutic application of self-assembled RNAi-AuNP nanoconstructs: Combination of VEGF-RNAi and photothermal ablation. Theranostics 2017;7:9-22 (PMID: 28042312).
19. Deepagan VG*, You DG*, Um W, Ko H, Kwon S, Choi KY, Yi GR, Lee JY, Lee DS, Kim K, Kwon, IC, Park JH. Long-circulating Au-TiO2 nanocomposite as a sonosensitizer for ROS-mediated eradication of cancer. Nano Letters 2016;16:6257–6264 (PMID: 27643533).
18. Chang H, Yhee JY, Jang GH, You DG, Ryu JH, Choi Y, Na JH, Park JH, Lee KH, Choi K, Kim K, Kwon IC. Predicting the in vivo accumulation of nanoparticles in tumor based on in vitro macrophage uptake and circulation in zebrafish. Journal of Controlled Release 2016;244:205-213 (PMID: 27435681).
17. Min HS, Son S, You DG, Lee TW, Lee J, Lee S, Yhee JY, Lee J, Han MH, Park JH, Kim SH, Choi K, Park K, Kim K, Kwon IC. Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery. Biomaterials 2016;108:57-70 (PMID: 27619240).
16. Deepagan VG, Kwon S, You DG, Nguyen VQ, Um W, Ko H, Lee H, Jo DG, Kang YM, Park JH. In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery. Biomaterials 2016;103:56-66 (PMID: 27372421).
15. Cha JM*, You DG*, Choi EJ, Park SJ, Um W, Jeon J, Kim K, Kwon IC, Park JC, Kim HR, Park JH. Improvement of antitumor efficacy by combination of thermosensitive liposome with high-intensity focused ultrasound. Journal of Biomedical Nanotechnology 2016;12:1724-1733 (PMID: 29345882).
14. Kim HR, You DG, Park SJ, Choi KS, Um WR, Kim JH, Park JH, Kim YS. MRI monitoring of tumor-selective anticancer drug delivery with stable thermosensitive liposomes triggered by high-intensity focused ultrasound. Molecular Pharmaceutics 2016;13:1528-1539 (PMID: 26998616).
13. You DG*, Deepagan VG*, Um W, Jeon S, Son S, Chang H, Yoon HI, Cho YW, Swierczewska M, Lee S, Pomper MG, Kwon IC, Kim K, Park JH. ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer. Scientific Reports 2016;6:23200 (highly cited paper; web of science, PMID: 26996446).
12. Lee J, Min HS, You DG, Kim K, Kwon IC, Rhim T, Lee KY. Theranostic gas-generating nanoparticles for targeted ultrasound imaging and treatment of neuroblastoma. Journal of Controlled Release 2016;223:197-206 (PMID: 26739549).
11. Lee ES, Deepagan VG, You DG, Jeon J, Yi GR, Lee JY, Lee DS, Suh Y, Park JH. Nanoparticles based on quantum dots and a luminol derivative: Implications for in vivo imaging of hydrogen peroxide by chemiluminescence resonance energy transfer. Chemical Communications 2016;52:4132-4135 (selected as the cover feature, PMID: 26857551).
10. Min HS*, You DG*, Son S, Jeon S, Yhee JY, Park JH, Lee S, Kwon IC, Kim K. Echogenic glycol chitosan nanoparticles for ultrasound-triggered cancer theranostics. Theranostics 2015;5:1402-1418 (selected as the cover feature, PMID: 26681985).
9. Jeon S, Ko H, Roa N. V, Yoon HY, You DG, Han HS, Um W, Saravanakumar G, Park JH. A versatile gold cross-linked nanoparticle based on triblock copolymer as the carrier of doxorubicin. RSC advances 2015;5:70352-70360 (Link).
8. Thambi T, You DG, Han HS, Deepagan VG, Jeon SM, Suh YD, Choi KY, Kim K, Kwon IC, Yi GR, Lee JY, Lee DS, Park JH. Bioreducible carboxymethyl dextran nanoparticles for tumor-targeted drug delivery. Advanced Healthcare Materials 2014;3:1829-1838 (selected as the cover feature, PMID: 24753360).
7. Yoon HY, Son S, Lee SJ, You DG, Yhee JY, Park JH, Swierczewska M, Lee S, Kwon IC, Kim SH, Kim K, Pomper MG. Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Scientific Reports 2014;4:6878 (PMID: 25363213).
6. Son S, Min HS, You DG, Kim BS, Kwon IC. Echogenic nanoparticles for ultrasound technologies: Evolution from diagnostic imaging modality to multimodal theranostic agent. Nano Today 2014;9:525-540 (Link).
5. Shin JM, Kim SH, Thambi T, You DG, Jeon J, Lee JO, Chung BY, Jo DG, Park JH. A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis. Chemical Communications 2014;50:7632-7635 (PMID: 24893961).
4. Ryu JH, Na JH, Ko HK, You DG, Park S, Jun E, Yeom HJ, Seo DH, Park JH, Jeong SY, Kim IS, Kim BS, Kwon IC, Choi K, Kim K. Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models. Biomaterials 2014;35:2302-2311 (PMID: 24360720).
3. You DG*, Saravanakumar G*, Son S, Han HS, Heo R, Kim K, Kwon IC, Lee JY, Park JH. Dextran sulfate-coated superparamagnetic iron oxide nanoparticles as a contrast agent for atherosclerosis imaging. Carbohydrate Polymers 2014;101:1225-1233 (PMID: 24299895).
2. Kim SH, Kim JH, You DG, Saravanakumar G, Yoon HY, Choi KY, Thambi T, Deepagan VG, Jo DG, Park JH. Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis. Chemical Communications 2013;49:10335-10434 (selected as the cover feature, PMID: 23942894).
1. Han HS, Lee J, Kim HR, Chae SY, Kim M, Saravanakumar G, Yoon HY, You DG, Ko H, Kim K, Kwon IC, Park JC, Park JH. Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: Mineralization and its effect on tumor targetability in vivo. Journal of Controlled Release 2013;168:105-114 (PMID: 23474029).
Park JH, Lee D, You DG, An JY, Jung JM. Filler composition for anti-wrinkle of skin comprising exosome derived from stem cell and temperature-sensitive biocompatible polymer, and Method for manufacturing thereof.
KR 10-2022-0000692, Field on January 4, 2022.
Cho YW, Park JH, You DG, Oh BH, Nguyen VQ, Lim GT, Choi, JS, Choi, YC, Jung, YJ. A pharmaceutical composition for preventing or treating liver fibrosis containing exosomes surface-modified with vitamin A.
KR 10-2021-0032997, Field on March 22, 2021.
Park JH, You DG, An JY. Filler composition comprising exosome derived from stem cell, hyaluronic acid, and BDDE for anti-wrinkle of skin, and method for manufacturing thereof.
KR 10-2021-0008276, Field on January 20, 2021.
PCT/KR2022/000894, Field on January 18, 2022.
US 18/697,856, Field on March 21, 2024.
Park JH, You DG, Lim GT. Oh BH, Jung JM, Um W, Kim CH. Composition for preventing or treating inflammatory macrophage-mediated autoimmune disease comprising exosomes derived from stem cells that are surface-modified to target activated macrophages.
KR 10-2652322, Issued on March 25, 2024.
US 17/474,118, Field on November 14, 2021.
Park JH, You DG, Deepagan VG, Lee MC. Sonosensitizer composition containing titanium oxide nanoparticles as active ingredient, composition for preventing or treating cancer comprising the same, and preparation thereof.
KR 10-1702227, Issued on January 25, 2017.
US 14/797,435, Filed on July 13, 2015.
Park JH, Kang YM, Kwon IC, Kim K, Han HS, Yoon HY, You DG. Drug carrier comprising mineralized amphiphilic nanoparticles containing poly(ethylene glycol).
KR 10-352316, Issued on January 09, 2014.
Park JH, Kwon IC, Kim K, You DG, Yoon HY, Han HS. Iron oxide hybrid nanoparticles coated with block copolymer containing dextran sulfate, a preparation method thereof and a contrast agent for atherosclerosis imaging comprising the same.
KR 10-1286347, Issued on July 09, 2013