Namju and Yeji's Paper Has Been Published in
Advanced Materials Technologies
posted 2024-03-25
posted 2024-03-25
Namju and Yeji's paper on "Double-Sided, Thin-Film Microelectrode Array with Hemispheric Electrodes for Subretinal Stimulation" has been published in Advanced Materials Technologies. Congratulations!
Components in neural implants, such as the electrode array and stimulator circuit, are often fabricated discretely. This modular fabrication schemeoffers flexibility during development but poses difficulties during assembly, ascomponents must be compactly integrated for implantation. It is particularlydifficult in cases where the electrode array is required to have a high number ofchannels, such as in retinal prostheses. This paper presents the developmentof a parylene C-based, double-sided microelectrode array with 294hemispheric electrodes for subretinal stimulation. The bonding pads on thebottom side of the double-sided array are connected with electrodes throughvias, eliminating the interconnection lines. The array can be integratedwith a stimulator circuit through pad-to-pad bonding, resulting in a compactimplant. The hemispheric electrodes are fabricated using thermally reflowedphotoresist infillings, through which the height and width of the hemispherescan be easily controlled. The long-term stability and biocompatibilityof the materials and methods used to fabricate and package the electrodesare demonstrated in in vitro and in vivo environments over months.Finally, subretinal stimulation by the developed electrodes is successfullydemonstrated using in vitro retinal patches from mice and monkeys.