Jun-Nyeong Shin's Paper Has Been Published in Frontier in Pharmacology
posted 2022-12-19
posted 2022-12-19
Jun-Nyeong Shin's paper on "Zebrafish EEG predicts the efficacy of antiepileptic drugs" has been published in Frontier in Pharmacology. Congratulations!
Pharmacological evaluation of antiepileptic drugs (AEDs) using mammalian animals takes long time and is expensive. The zebrafish is a species commonly used to study brain functions, neurological diseases, and drug toxicity, and attracts more attention as an alternative animal model to substitute or supplement mammalian animals in drug development. Electroencephalogram (EEG) is a key indicator for diagnosing brain diseases such as epilepsy, by directly measuring the brain activity. We propose a novel method for pharmacological evaluation of AEDs based on EEG from adult zebrafish, which allows researchers to select more clinically valuable drugs at the early stage of AED screening.