Capability

Collaborative Support

Collaborative proposals are welcome. 

Synthesis of deuterated materials

1. • deuterated small molecules: deuterated reagents, deuterated drugs, deuterated organocatalysts, deuterated aromatics

   • D2 gas 

   • deuterated proteins

Direct deuteration methods of complex molecules

1. • Drugs to D-drugs

   • Aromatic compounds to D-aromatics
     
     

Theoretical calculations of deuterated materials

1. • MC_MO (multi-component molecular orbital) method

   • MC_DFT (multi-component density functional theory) method

Analytical measurements of deuterated materials

1. • in situ IR spectroscopy

   • in situ Raman spectroscopy

   • Deuterium(2H)-NMR

   • Separation of deuterated/non-deuterated molecules with column chromatography

   • Single crystallographic neutron diffraction analysis (of deuterated protein)

   • SAXS, SANS (of deuterated protein)
     
     

Metabolic study

• KIEs

• ADME

D2O recovery

If you have any questions, please email deuteriumscience@pharm.kyoto-u.ac.jp or individual researchers.

Consulting Service

Academic

Directly email deuteriumscience@pharm.kyoto-u.ac.jp or contact individual PIs. 

Non-academic

Paid consultation services from non-academic require consultation fees. Apply through the SACI website by indicating the name of Dr. Hiroshi Naka (or other Kyoto U. PIs of interest) in the contact form. Direct email to deuteriumscience@pharm.kyoto-u.ac.jp from non-academic may not be responded to.

Catalogue of Deuterated Molecules

The catalog of deuterated molecules we synthesized is available via the link below.

Samples can be used as collaborative. 

For inquiries about the catalogue, send an email to deuteriumscience@pharm.kyoto-u.ac.jp.