The Dephoure Lab develops and applies quantitative proteomic methods to uncover the roles of cell-signaling pathways in human disease.
We use high resolution and highly sensitive LC-MS/MS to identify changes in protein modifications, localizations, and abundance in human disease models. Most of our projects are focused on cancer and neurodegenerative diseases using cell and mouse models. We are experts in the analysis of post-translational modifications, notably phosphorylation, and in the use of multiplexed isobaric tagging reagents for quantification.
Current projects include:
The role of autophagy in neurodegenerative diseases, including ALS, AD, FTD, PD.
Kinase signaling in innate immune response and neurodegenerative disease models.
Multiproteomic methods to study the epithelial to mesenchymal transition.
Immunopeptidomics - Radiotherapy induced changes in MHC-I phosphoantigens