SELF-ORGANIZATION IN BIOLOGICAL SYSTEMS

In nature we can find multiple examples of patterns and organized arrangements that have been exploited for biological purposes by living beings since their origin. In this context, with the aim to guarantee the correct development of biochemical reactions and biological processes, cells require the spatiotemporal organization of their components.

Cells achieve this organization through mechanical actions such as active transport and membrane isolated compartments but also by exploiting the physicochemical properties of molecules. Specifically, the last is employed to attract and concentrate different components from the cellular milieu.

Our lab is focused on understand the self-organization of protein mixtures through the study of their interactions at molecular level. In this sense, protein interactions can result in different organized assemblages with diverse biophysical properties and biological purposes. They can build strong and resistant amyloid fibrils with structural, adaptative and epigenetic purposes. But also, active, sensitive and modulable biological condensates with metabolic and regulatory functions.