Research Highlight
Research Highlight
I am interested in working at the interface of biology and biophysics to understand the fundamentals of cellular trafficking and its regulation. We love to resolve the regulators of intracellular transport using a home-built super-resolution microscope based on a single-molecule localization approach (Stochastic Optical Reconstruction Microscopy (STORM)
Live cell imaging of Microtubules
My PhD research aims to understand how cells employ regulatory cues embedded in microtubules to orchestrate motor-mediated long-range transport of lysosomes. Complex microtubule architecture and molecular crowding make the regulation of motor-based transport uniquely complex.
Dissecting the mechanistic regulation of how, when and why lysosomes move is of great relevance due to a strong correlation between abnormal spatiotemporal positioning of lysosomes and myriads of disorders.
TIRF vs STORM imaging
Conventional TIRF vs Super resolution STORM imaging
3D STORM imaging of LC3B on Autophagosomes