The research in our group is highly interdisciplinary, at the cross-roads of physics, chemistry and biology. During the last couple of years, our work has primarily focused on understanding how biomolecules, such as proteins and nucleic acids accomplish their functional roles through optimal spatio-temporal tuning of their structure and dynamics. To obtain a critical understanding of these intimate connections at the microscopic level, we use computer simulations based on ideas rooted in equilibrium statistical physics and energy landscape theory. One of our prominent research themes is developing highly robust and transferable mesoscale models for complex macromolecular systems. When necessary, we also resort to fully atomistic (force-field based) or high-level quantum calculations.
SOME HIGHLIGHTS OF OUR RECENT WORK..