Programma Scientifico

Lunedì, 20 giugno 2022

12:30 - 14:20 Registrazione dei partecipanti

14:20 - 14:30 Cerimonia di apertura

Chairpersons: Michael Assfalg - Francesco Peri

14:30 - 15:15 PL01: Alba Silipo

"Unveiling the puzzle of microbial glycans: how to correlate the structure to the function"

15:15 - 15:35 OR01: Cristina Airoldi

"Multivalent ligands for bacteria targeting"

15:35 - 15:55 OR02: Francesco Musiani

"Computational studies on internal tunnels of the Helicobacter pylori UreDFG multimeric protein complex"

15:55 - 16:15 OR03: Francesco Bellia

"Natural and synthetic effectors of alpha-synuclein: features and interplays"

16:15 - 16:55 Coffee break & Poster Session 1 (PO01-PO11)

Chairpersons: Gianluca Caprini - Carla Isernia

16:55 - 17:00 Cerimonia di consegna del Premio Italfarmaco “G. De Santis”

17:00 - 17:30 AL01: Alessandro D'Urso

"Porphyrins as chiroptical probe for biomolecule's conformations"

17:30 - 18:00 AL02: Francesca Munari

"Ubiquitination of the Alzheimer’s disease related protein Tau by enzymatic and chemical methods: effects on the mechanism of amyloids formation"

18:00 - 18:15 OR04: Aurane Froux

"G-quadruplex binding by transition metal complexes: the whole pathway from design to synthesis, to in cellulo anticancer investigations"

18:15 - 18:30 OR05: Claudia Riccardi

"Design, synthesis and characterization of lipophilic Ru(III) complexes as potential antitumor agents"

18:30 - 19:30 Assemblea dei Soci della Divisione di Chimica dei Sistemi Biologici

Martedì, 21 giugno 2022

Chairpersons: Massimiliano Coletta - Roberto Fattorusso

09:00 - 09:45 PL02: Maurizio Pellecchia

"NMR- and structure-guided design of potent ligands and molecular degraders to protein-protein interactions"

09:45 - 10:05 OR06: Daniela Arosio

"Triazine-Based Small Molecules as Novel PD-L1 Inhibitors"

10:05 - 10:25 OR07: Cecilia Pozzi

"Structural characterization of YAP-TEAD4 protein-protein interaction: an emerging target for cancer treatment"

10:25 - 10:45 OR08: Luigi Russo

"High-resolution NMR-based approach for studying receptor-ligand interactions on living cells surface"

10:45 - 11:30 Coffee break & Poster Session 2 (PO12-PO22)

Chairpersons: Roberta Pierattelli - Michele Saviano

11:30 - 11:45 OR09: Angelo Gallo

"Protein-protein interaction in polyketides producing antibiotic"

11:45 - 12:00 OR10: Gianluca D'Abrosca

"Screening a molecular fragment library to modulate PED/PEA15-Phospholipase D1 interaction in cellular lysate environments"

12:00 - 12:15 OR11: Giusy Tassone

"Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/ c-Abl Protein−Protein Interaction "

12:15 - 12:30 OR12: Giovanna Viola

"Elucidating the interaction between ultrasmall gold nanoparticles and the amyloidogenic protein tau"

12:30 - 12:45 OR13: Valeria Lanza

"Interactions between trehalose-silybins conjugates and Aβ oligomers: a biophysical and in vitro study"

12:45 - 13:00 OR14: Rita Pagano

"Silybin-tyrosol conjugates as promising Multitarget Ligands (MTLs) to contrast neurodegenerative diseases"

13:00 - 14:30 Pranzo

Chairpersons: Jussara Amato - Daniela Montesarchio

14:30 - 15:15 PL03: Roberto Improta

"Photophysics and photochemistry of DNA: insights from Quantum Mechanical calculations"

15:15 - 15:30 OR15: Angelo Spinello

"Unraveling the molecular basis of aberrant splice sites recognition by the SF3b splicing factor via all-atom simulations"

15:30 - 15:45 OR16: Riccardo Rozza

"Unraveling the molecular recognition and inhibition mechanism of the U2AF2 splicing factor"

15:45 - 16:00 OR17: Silvia Rinaldi

"A dynamic recognition of t1-adenosine sheds new lights on human Argonaute-2 protein target affinity"

16:00 - 16:30 Coffee break

16:30 - 16:45 OR18: Gabriele Travagliante

"Interactions between achiral porphyrins and a mature miRNA"

16:45 - 17:00 OR19: Rita Tosto

"Porphyrin-KLVFF conjugates as theranostic tools in Alzheimer’s Disease"

17:00 Visita Guidata (opzionale)

20:00 Cena Sociale

Mercoledì, 22 giugno 2022

Chairpersons: Danilo Milardi - Gaetano Malgieri

09:00 - 09:45 PL04: Antonio Rosato

"A bird’s eye view of metalloproteins"

09:45 - 10:05 OR20: Laura Cipolla

"Gelatin-based hydrogels: preparation and applications"

10:05 - 10:25 OR21: Marilisa Leone

"Design and evaluation of potential anticancer agents targeting the Sam domain of EphA2 receptor and its interactome"

10:25 - 10:45 OR22: Anna Maria Santoro

"Bio-inspired proteasome enhancers"

10:45 - 11:30 Coffee break & Poster Session 3 (PO23-PO34)

Chairpersons: Alessandra Magistrato - Antonio Rosato

11:30 - 11:45 OR23: Federica Moraca

"Structural insights of the ubiquitylation effects on the human Bardet-Biedl Syndrome (BBS) complex through Coarse-Grained Molecular Dynamics simulations"

11:45 - 12:00 OR24: Laura Rigobello

"Computational study of pathogenetic mutations in the transmembrane domain of Complex I of the respiratory chain"

12:00 - 12:15 OR25: Matteo Castelli

"Conformational selection at atomic level: the effects of glycosylation and modulators on Grp94"

12:15 - 12:30 OR26: Massimiliano Gaeta

"DOPA-melanin polymers as versatile bio-inspired material for multipurpose applications"

12:30 - 12:45 OR27: Veronica Ghini

"Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients"

12:45 - 13:00 OR28: Alessia Vignoli

"Risk stratification in patients with atrial fibrillation on oral anticoagulants: an NMR-based metabolomics and lipoproteomics study"

13:00 - 13:15 Conclusione dei Lavori