Selected Publications
TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
Sebastián D, Beltrà M, Irazoki A, Sala D, Aparicio P, Aris C, Alibakhshi E, Rubio-Valera M, Palacín M, Castellanos J, Lores L, Zorzano A
Autophagy. 2024 Mar 28:1-10. doi: 10.1080/15548627.2024.2333717
Mitochondrial fitness sustains healthy muscle aging
Irazoki A, Zorzano A, Sebastián D.
Aging (Albany NY). 2023, Jun 24; 15 doi: 10.18632/aging.204857
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
Naón D, Hernández-Alvarez MI, Shinjo S, Wieczor M, Ivanova S, Martins de Brito O, Quintana A, Hidalgo J, Palacín M, Aparicio P, Castellanos J, Lores L, Sebastián D, Fernández-Veledo S, Vendrell J, Joven J, Orozco M, Zorzano A, Scorrano L
Science. 2023, Jun 23; 380 (6651) doi: 10.1126/science.adh9351
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Irazoki A, Gordaliza-Alaguero I, Frank E, Giakoumakis NN, Seco J, Palacín M, Gumà A, Sylow L, Sebastián D*, Zorzano A*. (*co-corresponding authors)
Nat Commun. 2023, Jan 6;14(1):108. doi: 10.1038/s41467-022-35732-1.
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease
López-Vicario C, Sebastián D, Casulleras M, Duran-Güell M, Flores-Costa R, Aguilar F, Lozano JJ, Zhang IW, Titos E, Kang JX, Zorzano A, Arita M, Clària J.
Hepatology. 2022 Jul 5. doi: 10.1002/hep.32647
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging
Irazoki A, Martinez-Vicente M, Aparicio P, Aris C, Alibakhshi E, Rubio-Valera M, Castellanos J, Lores L, Palacín M, Gumà A, Zorzano A, Sebastián D.
Aging Cell. 2022 Apr;21(4):e13583. doi: 10.1111/acel.13583.
Self-Eating for Muscle Fitness: Autophagy in the Control of Energy Metabolism
Sebastián D, Zorzano A.
Dev Cell. 2020 Jul 20;54(2):268-281. doi: 10.1016/j.devcel.2020.06.030.
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A.
Cell. 2019 May 2;177(4):881-895.e17. doi: 10.1016/j.cell.2019.04.010
Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
Miret-Casals L, Sebastián D, Brea J, Rico-Leo EM, Palacín M, Fernández-Salguero PM, Loza MI, Albericio F, Zorzano A.
Cell Chem Biol. 2018 Mar 15;25(3):268-278.e4. doi: 10.1016/j.chembiol.2017.12.001.
Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging
Sebastián D, Palacín M, Zorzano A..
Trends Mol Med. 2017 Mar;23(3):201-215. doi: 10.1016/j.molmed.2017.01.003.
When MFN2 (mitofusin 2) met autophagy: A new age for old muscles
Sebastián D, Zorzano A.
Autophagy. 2016 Nov;12(11):2250-2251. doi: 10.1080/15548627.2016.1215383.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A.
EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084.
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A.
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109.
