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I am interested in understanding how the body regulates neuronal function across the lifespan, and in the molecular and cellular mechanisms that preserve cognition during aging. My work centres on the hippocampus, where I study how systemic and metabolic signals reshape neuronal epigenetics and autophagy to sustain memory. I address these questions in vivo, combining mouse genetics and behaviour with molecular and cellular biology.
I am interested in understanding how the body regulates neuronal function across the lifespan, and in the molecular and cellular mechanisms that preserve cognition during aging. My work centres on the hippocampus, where I study how systemic and metabolic signals reshape neuronal epigenetics and autophagy to sustain memory. I address these questions in vivo, combining mouse genetics and behaviour with molecular and cellular biology.
Biosketch:
I began my scientific career as a neurobiologist in the group of Dr. Xavier Navarro (Universitat Autònoma de Barcelona). During my PhD under the supervision of Dr. Caty Casas, I explored the potential of Systems Biology and Artificial Neural Networks to discover novel therapies for nerve injuries. I provided clear evidence that boosting the endogenous mechanisms of cellular resilience exerts neuroprotection in the nervous system, and discovered NeuroHeal, a pharmacotherapy that enhances endogenous neuroprotection. During this period, I trained in cellular and molecular neurobiology and became familiar with Systems Biology and Artificial Intelligence. A copy of my thesis can be found here.
After defending my PhD (October 2017), I carried out a short postdoc in the same lab and, in 2019, co-founded the spin-off NeuroHeal Biomedicals to translate this therapy. In October 2019, I moved to the Institut Necker Enfants-Malades (Paris, France). I joined the group of Dr. Franck Oury, where my work shifted to the role of the systemic milieu and body–brain endocrine axes in nervous-system function during ageing. I investigate how bone-derived hormones such as osteocalcin are sensed by HpC neurons to regulate memory, and I have found that SIRT1-dependent epigenetics control hippocampal autophagy and memory. In 2021, I was awarded an MSCA fellowship to analyse the role of systemic factors in age-related locomotor decline, which allowed me to develop expertise in mitochondrial function. I also spent time as Visiting Researcher at Prof. Gerard Karsenty’s laboratory at Columbia University, where I acquired specialized expertise in bone-derived hormones.
In 2025, I was appointed as a permanent INSERM researcher (CRCN), and in June 2026, I obtained my Habilitation to Direct Research (HDR). I currently lead my own small research team within the Integrative Neurobiology group headed by Dr. Franck Oury. As Principal Investigator, I develop and supervise independent research lines investigating the molecular and cellular mechanisms underlying cognitive ageing. My research combines mitochondrial biology, epigenetics, and in vivo mouse behavioural approaches, with a particular focus on mitochondrial function, SIRT1, neddylation, and autophagy in hippocampal neurons.
Contact details
Contact details
Laboratory "Hormonal regulation of brain development and functions"
INEM INSERM U 1151- CNRS UMR 8253 - Faculté de Médecine
156-160, rue de Vaugirard
75015 Paris
+33 01 40 61 53 57
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