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AN UNUSUAL COMPLICATION OF PULMONARY SILICOSIS
AN UNUSUAL COMPLICATION OF PULMONARY SILICOSIS
Silica can trigger autoimmune diseases via production of autoantibodies .
Silica can trigger autoimmune diseases via production of autoantibodies .
We describe a case of pulmonary silicosis complicated by microscopic polyangiitis.
CONCLUSION: We report a case of pulmonary silicosis with P-ANCA associated microscopic polyangiitis.
Our case is unique in that both diagnoses are definitively proven histologically.
Exposure to silica should be considered in the history of patients with autoimmune diseases.
Furthermore patients with pulmonary silicosis may develop ANCA-associated vasculitis in extrapulmonary sites.
SILICA EXPOSURE AND SCLERODERMA
SILICA EXPOSURE AND SCLERODERMA
Although L. D. Erasmus was historically the first to link silica exposure with the occurrence of systemic sclerosis (SSc or scleroderma), B. Bramwell, a Scottish physician, had described an outbreak of scleroderma among stonemasons 50 years before .
Despite this ancient association, SSc is still largely considered today to be of unknown cause.
The alarming recent outbreak of silica-associated CTD may provide an opportunity to fill this gap and offer a timely lever to collectively better understand the pathogenesis of SSc.
SILICA DUST, CRYSTALLINE, IN THE FORM OF QUARTZ OR CRISTOBALITE
Silicosis, then microscopic polyangiitis antineutrophil cytoplasmic antibodies‐associated vasculitis may be work‐related disease in patients with silicosis
Silicosis, then microscopic polyangiitis antineutrophil cytoplasmic antibodies‐associated vasculitis may be work‐related disease in patients with silicosis
Microscopic polyangiitis (MPA) is a primary systemic vasculitis commonly known as antineutrophil cytoplasmic antibodies (ANCA)‐associated vasculitis (AAV), characterized by inflammation of small‐sized blood vessels and serum positivity of ANCA. Patients with MPA typically present with pulmonary, kidney, and neurologic manifestations.
Although the definitive pathophysiology of MPA is still not fully understood, certain factors such as drugs, bacteria, and dust exposure are known to trigger the development of this disorder.
Herein, we describe a case of MPA in a patient with longstanding occupational dust exposure.
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