Epidermal wearable sensor

1. Electro-colorimetric (EC) sensor platform

• Concept:

  • To simultaneously address the challenges of portability and sensitivity for the sweat sensor, I developed wearable display and integrated with an electrochemical sensor.

• What I did:

  • I proposed the concept upon entering the master's program, after which the experiment was conducted independently, and the research paper was written by myself (First Author, under revision at Science Advances).

  • To realize the first "wearable display", various strategies including polymer synthesis, microfabrication, and signal processing were applied to biofuel-based amperometric sensor.

  • An independent evaluation method was developed to quantitatively assess its performance.

  • Additionally, I planned and conducted human experiments.

• Expansion:

  • The performance was demonstrated through human trials and further validated by related patent.

2. Microfludics-subsidized SERS/colorimeric dual sensor

• Concept:

  • I developed an integrated device by incorporating a microfluidic channel and devising an enzyme cascade that enables simultaneous SERS and colorimetric analysis, allowing for the accurate analysis of various biomarkers in sweat. 

  • This also incorporates a strategy for normalizing SERS signals through the precise design of microfluidic channels.

• What I did:

  • After I participating in a project aimed at detecting biomarkers in sweat using SERS, I proposed and developed the main concepts above (First Author, to be submitted to Nature communications).

  • I conducted the main experiments including microfabrication for device integration, as well as optimization for enzyme cascade and Raman detection.

  • Additionally, I planned and conducted human experiments for patients.

• Expansion:

  • The performance was demonstrated through human trials and further validated by related three patents. Field demonstration was also conducted in Tanzania for the cost-effective, bulk-free SERS strategy to distinguish the life cycle of Schistosoma parasite and thus facilitate spatial mapping of them.