Richard Emsley, King's College London.

• Title: Frequentist and Bayesian approaches to rescuing disrupted trials

• Abstract: There is a severe threat to the validity of clinical trials that were underway before the COVID-19 pandemic and potentially huge research waste. Many studies were paused and recruitment restarted without due consideration of whether all studies should restart, or to required changes in sample sizes. There is also a need for solutions to practical and statistical issues (e.g. increased missing data) that have arisen from the virus and its sequelae. This talk will present some of these challenges, and discuss frequentist and Bayesian approaches to rescuing disrupted trials. The contents are drawn from a report on this topic from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions.