Speakers

The students who will be attending the Symposium are listed below.

Lucie Rémy-Demolie

The value of systematic screening for TTR amyloidosis in patients with idiopathic peripheral neuropathy

NeurIT Unit research 20218, Limoges

Hereditary transthyretin amyloidosis (hATTR) is a progressive hereditary disease caused by mutation of the TTR gene. To date, 140 mutations have been described in the literature, promoting misfolding of the transthyretin protein that accumulates in target organs. Familial amyloid polyneuropathy (FAP) is a severe systemic pathology responsible for sensory-motor polyneuropathy associated with dysautonomia. New treatments have recently emerged and are efficient in the management of FAP. The aim of this study is to determine the value of systematic screening for hATTR in patients with idiopathic peripheral neuropathy using salivary DNA extraction.

lucie.remy.demolie@etu.univ-poitiers.fr

Sébastien Laburthe

The role of sortilin in the polarization of monocytes into type 1 and 2 macrophages in giant cell arteritis

CapTur Unit INSERM 1308, Limoges

Neurological and ophthalmological complications of giant cell arteritis [GCA] make it vital to understand its pathophysiology and find an effective treatment. Mechanisms underlying macrophage polarization toward M1 or M2, involved in the destruction of the arterial wall, remain poorly understood. Although preliminary data showed increased expression of sortilin (SORT1 gene) in M2 macrophages in patients with GCA, the involvement of this neurotensin in polarization remains to be explored.

sebastien.laburthe@etu.univ-poitiers.fr

Victorina Mananga

Study of the phenotypic and functional characteristics of human skin cells isolated from different donor sites

LITEC, Poitiers

For child and especially little boys, the foreskins are used to make autotransplant during deep burns because their keratinocyte cells have a great capacity for proliferation and epidermis reconstruction. The aim is to better characterize the keratinocyte populations of the ear pinna and the inguinal skin in order to define them as new alternative sites to autotransplant.

victorina.mananga@etu.univ-poitiers.fr

Valentin Philippe

Quantification of sleep interruptions in medical intensive care patients

CIC 1402, Poitiers

The sleep of intensive care patients is often perturbed by factors such as light, noise, stress and pain. Lack of sleep in these patients can lead to difficulties in withdrawal of artificial ventilation or to excess mortality. The study uses a patented box that analyzes EEG, and captures light and sound. This device makes it possible to know when the patient is asleep and thus protects his sleep effectively. The aim is to find out whether this sleep-guided protection improves the quality of sleep in intensive care patients.

valentin.philippe@etu.univ-poitiers.fr

Tiphaine Lampire

Identification of vaccinia virus mutants with altered recombination activity

IRBA, Brétiny-sur-Orge

Very little is known about the replication mechanism of the vaccine virus, but it could be a good target for antiviral drugs. We do not know the role of the recombinant activity of DNA polymerase. The study will focus on creating vaccine viruses with mutations in the DNA polymerase gene that have lost this activity. The aim is to identify the mutation responsible for the phenotype obtained. These could be used in new vaccines that would be more genetically stable.

tiphaine.lampire@etu.univ-poitiers.fr

Salomé Fourmond

Bullous pemphigoid: Characterization of an immunoscore to analyze therapeutic response to dupilumab and omalizumab therapy

CapTur Unit INSERM 1308, Limoges

Bullous pemphigoid (BP) is a rare but common autoimmune bullous dermatosis of the elderly (>80y).

The problem is therapeutic because the use of immunosuppressants or high-dose systemic corticosteroids generate serious adverse events in these elderly. The aim of this project is to identify immune parameters that could be used to establish response criteria to treatment with dupilumab, a therapeutic monoclonal antibody that targets the IL4R alpha receptor or to omalizumab, a therapeutic anti-IgE antibody, 2 less immunosuppressive therapies.

salome.fourmond@etu.univ-poitiers.fr

Olga Coutinho

PK/PD study of an antibiotic combination in an animal model

U1070 Pharmacology of Antimicrobial Agents and antibioResistance, Poitiers

Bacterial infections caused by carbapenemase-producing Enterobacteriaceae are a major health problem. The combination ceftazidime/avibactam is one of the new therapeutic options available. The goal is to develop pharmacokinetically guided target concentrations and optimize dosage regimens for BL/BLI in combination with FOS using innovative in vitro pharmacokinetic and in vivo confirmatory models.

olga.coutinho@etu.univ-poitiers.fr

Silvia Martinez Rivera

Study of the T immune response in hypersensitivity to glycopeptides

Centre of Drug Safety Science, Liverpool

Drug hypersensitivity is one of the best known, but least understood drug side-effects. Vancomycin is a frequent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality. The aim of this study is to understand how vancomycin activates T cells, to see whether specific HLA proteins are involved and to assess the cross-reactivity of glycopeptides.

silvia.martinez.rivera@etu.univ-poitiers.fr

Naïs Cuvilliez

Assessing the impact of particular chemotherapy treatments on the anti-tumor effectiveness of Vg9Vd2 T cells targeting solid tumors

ImCheck, Marseille

This project evaluates the impact of chemotherapeutic treatments on the anti-tumor efficacy of Vg9Vd2 T cells against solid tumors. The monoclonal antibody ICT01, developed by ImCheck Therapeutics, activates these T cells to boost the immune response against cancer cells, by inducing a conformational change in the BTN3A expressed on malignant cells. Despite the possible immunosuppressive effects of certain chemotherapy agents, the project explores the combination of chemotherapy with immunotherapy, seeking to identify drugs that potentiate the antitumor function of Vg9Vd2 T cells for clinical evaluation with ICT01 in solid tumors.

nais.cuvilliez@gmail.com

Zélia Chauvaud

Characterization of metabolic defects associated with activation of TGFb signaling in muscle fiber

NeuroMyoGène Institute- CNRS 5261 - INSERM U1315, Lyon

Muscular atrophy reduces life expectancy. Actually, there is no treatment available to treat muscular atrophy. Spermine is a polyamine, with a high anti-aging potential. It could be a possible treatment to restore muscle size. To investigate this hypothesis, a mice model of muscular atrophy is given with spermine. The objective of this project is to determine the consequences of this injection on signalling pathways, on mitochondria metabolism and calcium homeostasis.

zelia.chauvaud@etu.univ-poitiers.fr

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