Welcome to CYP Lab

Publication

발표논문(Regular Articles since 2011)

(93) Kim KH, Kang JY, Kim DH, Park SH, Park SH, Kim D, Park KD, Lee YJ, Jung HC, Pan JG, Ahn T, Yun CH. (2011) Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. Drug Metab Dispos. 39(1):140-150.

1. (94) Park HG, Lee IS, Chun YJ, Yun CH, Johnston JB, Montellano PR, Kim D. (2011) Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans. Arch Biochem Biophys. 509(1):9-15.

2. (95) Kang JY, Kim SY, Kim D, Kim DH, Shin SM, Park SH, Kim KH, Jung HC, Pan JG, Joung YH, Chi YT, Chae HZ, Ahn T, Yun CH. (2011) Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium. AMB Express. 1(1):1.

3. (96) Han S, Choi S, Chun YJ, Yun CH, Lee CH, Shin HJ, Na HS, Chung MW, Kim D. (2012) Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35). Biol Pharm Bull. 35(3):394-399.

4. (97) Lo WS, Lim YP, Chen CC, Hsu CC, Souček P, Yun CH, Xie W, Ueng YF. (2012) A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation. Arch Toxicol. 86(12):1927-1938.

5. (98) Behrendorff JB, Moore CD, Kim KH, Kim DH, Smith CA, Johnston WA, Yun CH, Yost GS, Gillam EM. (2012) Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chem Res Toxicol. 25(9):1964-1974.

6. (99) Lim YR, Hong MK, Kim JK, Doan TT, Kim DH, Yun CH, Chun YJ, Kang LW, Kim D. (2012) Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway. Arch Biochem Biophys. 528(2):111-117.

7. (100) Park SH, Kang JY, Kim DH, Ahn T, Yun CH. (2012) The Flavin-Containing Reductase Domain of Cytochrome P450 BM3 Acts as a Surrogate for Mammalian NADPH-P450 Reductase. Biomol Ther (Seoul). 20(6):562-568.

8. (101) Jang HH, Kim SY, Kang JY, Park SH, Ryu SH, Ahn T, Yun CH. (2012) Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation. J Biochem. 152(5):433-442.

9. (102) Cho EY, Yun CH, Ahn T. (2012) Effects of phospholipids on the functional regulation of tBID in membranes. Mol Cell Biochem. 363(1-2):395-408.

10. (103) Yun CH, Chae HJ, Kim HR, Ahn T. (2012) Doxorubicin- and daunorubicin-induced regulation of Ca2+ and H+ fluxes through human bax inhibitor-1 reconstituted into membranes. J Pharm Sci. 101(3):1314-1326.

11. (104) Pan JG, Kim EJ, Yun CH. (2012) Bacillus spore display. Trends Biotechnol. 30(12):610-612.

12. (105) Lee KM, Kang HA, Park M, Lee HY, Choi HR, Yun CH, Oh JW, Kang HS. (2012) Interleukin-24 attenuates β-glycerophosphate-induced calcification of vascular smooth muscle cells by inhibiting apoptosis, the expression of calcification and osteoblastic markers, and the Wnt/β-catenin pathway. Biochem Biophys Res Commun. 428(1):50-55.

13. (106) Lee KM, Kang HS, Yun CH, Kwak HS. (2012) Potential in vitro Protective Effect of Quercetin, Catechin, Caffeic Acid and Phytic Acid against Ethanol-Induced Oxidative Stress in SK-Hep-1 Cells. Biomol Ther (Seoul). 20(5):492-8. doi: 10.4062/biomolther.2012.20.5.492.

14. (107) Lee KM, Kang HA, Ko CB, Oh EH, Park M, Lee HY, Choi HR, Yun CH, Jung WW, Oh JW, Kang HS. (2013) Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine. Int J Mol Med. 31(1):179-187.

15. (108) Kim DK, Kim YH, Jang HH, Park J, Kim JR, Koh M, Jeong WI, Koo SH, Park TS, Yun CH, Park SB, Chiang JY, Lee CH, Choi HS. (2013) Estrogen-related receptor γ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. Gut. 62(7):1044-1054.

16. (109) Hartman JH, Cothren SD, Park SH, Yun CH, Darsey JA, Miller GP. (2013) Predicting CYP2C19 catalytic parameters for enantioselective oxidations using artificial neural networks and a chirality code. Bioorg Med Chem. 21(13):3749-3759.

17. (110) Kim J, Lim YR, Han S, Han JS, Chun YJ, Yun CH, Lee CH, Kim D. (2013) Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C. Arch Pharm Res. 36(12):1500-6. doi: 10.1007/s12272-013-0212-5.

18. (111) Jang HH, Davydov DR, Lee GY, Yun CH, Halpert JR. (2014) The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. Arch Biochem Biophys. 545:100-107.
    (112) Kang JY, Ryu SH, Park SH, Cha GS, Kim DH, Kim KH, Hong AW, Ahn T, Pan JG, Joung YH, Kang HS, Yun CH. (2014) Chimeric cytochromes P450 engineered by domain swapping and random mutagenesis for producing human metabolites of drugs. Biotechnol Bioeng. 111(7):1313-22. doi: 10.1002/bit.25202.

1. (113) Ahn T, Bae CS, Yun CH. (2014) Affinity purification of recombinant human cytochrome P450s 3A4 and 1A2 using mixed micelle systems. Protein Expr Purif. 101:37-41. doi: 10.1016/j.pep.2014.05.010.
   (114) Lee GY, Kim HM, Ma SH, Park SH, Joung YH, Yun CH. (2014) Heterologous expression and functional characterization of the NADPH-cytochrome P450 reductase from Capsicum annuum. Plant Physiol Biochem. 82:116-22. doi: 10.1016/j.plaphy.2014.05.010.
   (115) Park KT, Yun CH, Bae CS, Ahn T. (2014) Decreased level of albumin in peripheral blood mononuclear cells of streptozotocin-induced diabetic rats. J Vet Med Sci. 76(8):1087-92.
   (116) Lee KH, Park M, Ji KY, Lee HY, Jang JH, Yoon IJ, Oh SS, Kim SM, Jeong YH, Yun CH, Kim MK, Lee IY, Choi HR, Ko KS, Kang HS. (2014) Bacterial β-(1,3)-glucan prevents DSS-induced IBD by restoring the reduced population of regulatory T cells. Immunobiology. 219(10):802-12. doi: 10.1016/j.imbio.2014.07.003.
   (117) Park EC, Kim SI, Hong Y, Hwang JW, Cho GS, Cha HN, Han JK, Yun CH, Park SY, Jang IS, Lee ZW, Choi JS, Kim S, Kim GH. (2014) Inhibition of CYP4A reduces hepatic endoplasmic reticulum stress and features of diabetes in mice. Gastroenterology. 147(4):860-9. doi: 10.1053/j.gastro.2014.06.039. Erratum in: Gastroenterology. 2015 Aug;149(2):509.

1. (118) Ryu SH, Park BY, Kim SY, Park SH, Jung HJ, Park M, Park KD, Ahn T, Kang HS, Yun CH. (2014) Regioselective hydroxylation of omeprazole enantiomers by bacterial CYP102A1 mutants. Drug Metab Dispos. 42(9):1493-7. doi: 10.1124/dmd.114.058636.

2. (119) Cha GS, Ryu SH, Ahn T, Yun CH. (2014) Regioselective hydroxylation of 17β-estradiol by mutants of CYP102A1 from Bacillus megaterium. Biotechnol Lett. 36(12):2501-6. doi: 10.1007/s10529-014-1628-9.

3. (120) Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP. (2014) Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 53(39):6161-72. doi: 10.1021/bi500710e.

4. (121) Park M, Yi JW, Kim EM, Yoon IJ, Lee EH, Lee HY, Ji KY, Lee KH, Jang JH, Oh SS, Yun CH, Kim SH, Lee KM, Song MG, Kim DH, Kang HS. (2015) Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity. Diabetes. 64(1):117-27. doi: 10.2337/db13-1869.

5. (122) Lee GY, Kim DH, Kim D, Ahn T, Yun CH. (2015) Functional characterization of steroid hydroxylase CYP106A1 derived from Bacillus megaterium. Arch Pharm Res. 38(1):98-107. doi: 10.1007/s12272-014-0366-9.

6. (123) Park JH, Lee SH, Cha GS, Choi DS, Nam DH, Lee JH, Lee JK, Yun CH, Jeong KJ, Park CB. (2015) Cofactor-free light-driven whole-cell cytochrome P450 catalysis. Angew Chem Int Ed Engl. 54(3):969-73. doi: 10.1002/anie.201410059.

7. (124) Lim YR, Kim IH, Han S, Park HG, Ko MJ, Chun YJ, Yun CH, Kim D. (2015) Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q). Biomol Ther (Seoul). 23(2):189-94. doi: 10.4062/biomolther.2015.009.

8. (125) Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D. (2015) Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A. Arch Biochem Biophys. 575:1-7. doi: 10.1016/j.abb.2015.03.025.

9. (126) Ueng YF, Chen CC, Huang YL, Lee IJ, Yun CH, Chen YH, Huang CC. (2015) Effects of aqueous extract of Ruta graveolens and its ingredients on cytochrome P450, uridine diphosphate (UDP)-glucuronosyltransferase, and reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-quinone oxidoreductase in mice. Journal of food and drug analysis 23:516-528.

10. (127) Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D. (2016) Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue. Mol Cells. 39(3):211-6. doi: 10.14348/molcells.2016.2226.

11. (128) Yun CH, Bae CS, Ahn T. (2016) Cargo-Free Nanoparticles Containing Cationic Lipids Induce Reactive Oxygen Species and Cell Death in HepG2 Cells. Biol Pharm Bull. 39(8):1338-46. doi: 10.1248/bpb.b16-00264.

12. (129) Yun CH, Bae CS, Ahn T. (2016) Transformation of Escherichia coli and protein expression using lipoplex mimicry. Protein Expr Purif. 127:68-72. doi: 10.1016/j.pep.2016.07.006.

13. (130) Ahn T, Bae CS, Yun CH. (2016) Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice. J Vet Med Sci. 78(4):669-74. doi: 10.1292/jvms.15-0611.

14. (131) Jang HH, chin SM, Ma SH, Lee GY, Joung YH, Yun CH. (2016) Role of Leu188 in the Fatty Acid Hydroxylase Activity of CYP102A1 from Bacillus megaterium. J Mol Catal B: Enzym 133:35-42.

15. (132) Le TK, Jang HH, Nguyen HT, Doan TT, Lee GY, Park KD, Ahn T, Joung YH, Kang HS, Yun CH., (2017) Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one-step synthesis of astringin, a piceatannol glucoside, by P450 BM3. Enzyme Microb Technol. 97:34–42. doi: 10.1016/j.enzmictec.2016.11.003.

16. (133) Han S, Pham TV, Kim JH, Lim YR, Park HG, Jeong D, Yun CH, Chun YJ, Kang LW, Kim D. (2017) Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 482(4):902-908. doi: 10.1016/j.bbrc.2016.11.131.

17. (134) Han S, Cha GS, Chun YJ, Lee CH, Kim D, Yun CH. (2016) Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G. Drug Metab Pharmacokinet. 31(6):445-450. doi: 10.1016/j.dmpk.2016.09.003.

18. (135) Jang HH, Ryu SH, Le TK, Doan TT, Nguyen TH, Park KD, Yim DE, Kim DH, Kang CK, Ahn T, Kang HS, Yun CH. (2017) Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite. Biotechnol Lett. 39(1):105-112. doi: 10.1007/s10529-016-2211-3.

19. (136) Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D. (2017) Characterization of a Biflaviolin Synthase CYP158A3 from Streptomyces avermitilis and Its Role in the Biosynthesis of Secondary Metabolites. Biomol Ther (Seoul). 25(2):171-176. doi: 10.4062/biomolther.2016.182.

20. (137) Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP. (2017) Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. J Biol Chem. 292(27):11230-11242. doi: 10.1074/jbc.M117.792200.

21. (138) Jo HY, Park SH, Le TK, Ma SH, Kim D, Ahn T, Joung YH, Yun CH. (2017) Peroxide-dependent oxidation reactions catalyzed by CYP191A1 from Mycobacterium smegmatis. Biotechnol Lett. 39(8):1245-1252. doi: 10.1007/s10529-017-2358-6.

22. (139) Lee SP, Park CM, Kim KS, Kim E, Jeong M, Shin JY, Yun CH, Kim K, Chock PB, Chae HZ. (2018) Structural and biochemical analyses reveal ubiquitin C-terminal hydrolase-L1 as a specific client of the peroxiredoxin II chaperone. Arch Biochem Biophys. 640:61-74. doi: 10.1016/j.abb.2018.01.003.

23. (140) Bae CS, Yun CH, Ahn T. (2018) Extracts from Erythronium japonicum and Corylopsis coreana Uyeki reduce 1,3-dichloro-2-propanol-mediated oxidative stress in human hepatic cells. Food Sci Biotechnol. 28(1):175-180. doi: 10.1007/s10068-018-0445-7.

24. (141) Yun CH, Bae CS, Ahn T. (2018) Cationic nanoparticles containing cationic peptide cargo synergistically induce cellular reactive oxygen species and cell death in HepG2 cells. International Journal of Prptide Research and Therpeutics. 25:323–327.

25. (142) Le TK, Park JH, Choi DS, Lee GY, Choi WS, Jeong KJ, Park CB, Yun CH. (2019) Solar-driven biocatalytic C-hydroxylation through direct transfer of photoinduced electrons. Green Chem., 21:515-525. doi: 10.1039/C8GC02398K.

26. (143) Kim SY, Jones DW, Kang JY, Yun CH, Miller GP. (2019) Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin. Xenobiotica 49(4):397-403. doi: 10.1080/00498254.2018.1451668.

27. (144) Kim SM, Kim EM, Ji KY, Lee HY, Lee SM, Yi JW, Yun CH, Choi H, Kang HS (2019) TREM2 Acts as a Tumor Suppressor in Colorectal Carcinoma through Wnt1/b-catenin and Erk Signaling. Cancers (Basel) 11(9):1315. doi: 10.3390/cancers11091315.

28. (145) Kim SM, Park M, Yee SM, Ji KY, Lee EH, Nguyen TV, Nguyen TH, Jang J, Kim EM, Choi HR, Yun CH, Kang HS. (2019) Axl is a key regulator of intestinal γδ T-cell homeostasis. FASEB J 33(12):13386-13397. doi: 10.1096/fj.201901356R.

29. (146) Le TK, Cha GS, Jang HH, Nguyen THH, Doan TTM, Lee YJ, Park KD, Shin Y, Kim DH, Yun CH (2019) Regioselective hydroxylation pathway of tenatoprazole to produce human metabolites by Bacillus megaterium CYP102A1. Process Biochemistry. 87:95-104. doi: 10.1016/j.procbio.2019.09.014

30. (147) Park CM, Jeong H, Ma SH, Kim HM, Joung YH, Yun CH. (2019) Application of Solanum lycopersicum Glucose-6- phosphate Dehydrogenase to NADPH-generating System for Cytochrome P450 Reactions. Microbiology and Biotechnology Letters. 47(4):536-545.

31. (148) Nguyen NA, Jang J, Le TK, Nguyen THH, Woo SM, Yoo SK, Lee YJ, Park KD, Yeom SJ, Kim GJ, Kang HS, Yun CH. (2020) Biocatalytic Production of a Potent Inhibitor of Adipocyte Differentiation from Phloretin Using Engineered CYP102A1. J. Agric. Food Chem. 68(24):6683–6691. doi:10.1021/acs.jafc.0c03156

(149) Nguyen, T.H.H.; Woo, S.-M.; Nguyen, N.A.; Cha, G.-S.; Yeom, S.-J.; Kang, H.-S.; Yun, C.-H. Regioselective Hydroxylation of Naringin Dihydrochalcone to Produce Neoeriocitrin Dihydrochalcone by CYP102A1 (BM3) Mutants. Catalysts , 10(8):823. doi.org/10.3390/catal10080823

발표논문(Regular Articles: 2004-2010)

1. (44) Ahn T, Yang S, Yun CH. (2004) Enhanced expression of human cytochrome P450 1A2 by co-expression with human molecular chaperone Hsp70. Toxicol Lett 153, 267-272

2. (45) Ahn T, Yun CH. (2004) Trehalose increases chemical-induced transformation efficiency of Escherichia coli. Anal Biochem 333, 199-200

3. (46) Ahn T, Yang S, Yun CH. (2004) High-level expression of human cytochrome P450 1A2 by co-expression with human molecular chaperone HDJ-1(Hsp40). Protein Expr Purif 36, 48-52

4. (47) Ahn T, Yun CH. (2004) High-level expression of human cytochrome P450 3A4 by co-expression with human molecular chaperone HDJ-1 (Hsp40). Arch Pharm Res 27, 319-323

5. (48) Ahn T, Kang SS, Yun CH. (2004) Improved long-term cryostorage of Escherichia coli competent cells using trehalose. Biotechnol Lett 26, 1593-1594

6. (49) Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH. (2004) Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Toxicol Lett 153, 239-246

7. (50) Yim SK, Yun SJ, Yun CH. (2004) A continuous spectrophotometric assay for NADPH-cytochrome P450 reductase activity using 1,1-diphenyl-2-picrylhydrazyl. J Biochem Mol Biol 37, 629-633

8. (51) Kim JS, Yun CH. (2005) Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion. Toxicol Lett 156, 341-350

9. (52) Lee SS, Jeong HE, Liu KH, Ryu JY, Moon T, Yoon CN, Oh SJ, Yun, CH, Shin JG. (2005) Identification and functional characterization of novel CYP2J2 varients: G312R variant causes loss of enzyme catalytic activity. Pharmacogenetics and Genomics 15, 105-113.

10. (53) Yun CH, Kim KH, Calcutt MW, Guengerich FP. (2005) Kinetic Analysis of Oxidation of Coumarins by Human Cytochrome P450 2A6. J Biol Chem 280, 12279-12291

11. (54) Yim SK, Ahn T, Jung HC, Pan JG, Yun CH. (2005) Temperature effect on the functional expression of human cytochromes P450 2A6 and 2E1 in Escherichia coli. Arch Pharm Res. 28, 433-437

12. (55) Yim SK, Yun CH, Ahn T, Jung HC, Pan JG. (2005) A continuous spectrophotometric assay for NADPH-cytochrome P450 reductase activity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. J Biochem Mol Biol. 38, 366-369

13. (56) Ahn T, Yun CH, Oh D B. (2005) Involvement of nonlamellar-prone lipids in the stability increase of human cytochrome P450 1A2 in reconstituted membranes. Biochemistry. 44, 9188-9196

14. (57) Kim KH, Isin EM, Yun CH, Kim DH., Guengerich FP. (2006) Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. FEBS J. 273, 2223-2231

15. (58) Yea SS, Jeong HS, Choi CY, Park KR, Oh S, Shin JG, Yun CH. (2006) Inhibitory effect of anethole on T-lymphocyte proliferation and interleukin-2 production through down-regulation of the NF-AT and AP-1. Toxicol In Vitro. 20, 1098-1105.

16. (59) Kim HK, Chun DS, Kim JS, Yun CH, Lee JH, Hong SK, Kang DK (2006) Expression of the cationic antimicrobial peptide lactoferricin fused with the anionic peptide in Escherichia coli.. Appl Microbiol Biotechnol. 72(2), 330-338.

17. (60) Yim SK, Jung HC, Pan JG, Kang HS, Ahn T, Yun CH. (2006) Functional Expression of Mammalian NADPH-Cytochrome P450 Oxidoreductase on the Cell Surface of Escherichia coli. Protein Expr Purif49, 292-298

18. (61) Ahn T, Yun CH, Oh DB. (2006) Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicol Lett 166, 27-36.

19. (62) Yim SK, Jung HC, Pan JG, Kang HS, Ahn T, Yun CH. (2006) Functional expression of mammalian NADPH-cytochrome P450 oxidoreductase on the cell surface of Escherichia coli. Protein Expr Purif. 49(2), 292-298.

20. (63) Yun CH, Kim KH, Kim DH, Jung HC, Pan JG. (2007) The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 25(7), 289-298. (Opinion Article)

21. (64) Park KR, Lee JH, Choi C, Liu KH, Seog DH, Kim YH, Kim DE, Yun CH, Yea SS. (2007) Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of NF-AT and NF-kappaB. Int Immunopharmacol. 7(9), 1251-1258.

22. (65) Yoo HH, Lee MW, Kim YC, Yun CH, Kim DH. (2007) Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas. Drug Metab Dispos. 35(10), 1759-1765.

23. (66) Kim M, Yun CH, Park SK, Seo JH, Ahn T. (2007) Production of polyclonal antibodies against peptide antigens using polystyrene beads as a carrier. Biotechnol Lett. 29(11), 1735-1740.

24. (67) Kim KH, Kim DH, Jang HH, Kim M, Kim DH, Kim JS, Kim JI, Chae HZ, Ahn T, Yun CH. (2007) Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Arch Biochem Biophys. 468(2):226-233.

25. (68) Kim DH, Kim GS, Yun CH, Lee YC. (2008) Functional conservation of the glutamine-rich domains of yeast Gal11 and human SRC-1 in the transactivation of glucocorticoid receptor Tau 1 in Saccharomyces cerevisiae. Mol Cell Biol. 28(3):913-925.

26. (69) Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH. (2008) Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. Protein Expr Purif. 57(2):188-200.

27. (70) Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY. (2008) An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. Exp Mol Med. 40(2):254-260.

28. (71) Cho EY, Yun CH, Chae HZ, Chae HJ, Ahn T. (2008) Anionic phospholipid-induced regulation of reactive oxygen species production by human cytochrome P450 2E1. FEBS Lett. 582(12):1771-1776.

29. (72) Kim DH, Kim KH, Kim DH, Liu KH, Jung HC, Pan JG, Yun CH. (2008) Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3. Drug Metab Dispos. 36(11):2166-70.

30. (73) Cho EY, Yun CH, Chae HZ, Chae HJ, Ahn T. (2008) Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. Biochem Biophys Res Commun. 376(3):584-589.

31. (74) Yim SK, Jung HC, Yun CH, Pan JG. (2009) Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display. Protein Expr Purif. 63(1):5-11.

32. (75) Kim DH, Yim SK, Kim KH, Ahn T, Yun CH. (2009) Continuous spectrofluorometric and spectrophotometric assays for NADPH-cytochrome P450 reductase activity using 5-cyano-2,3-ditolyl tetrazolium chloride. Biotechnol Lett. 31(2):271-5.

33. (76) Ahn T, Yun CH, Chae HZ, Kim HR, Chae HJ. (2009) Ca2+/H+ antiporter-like activity of human recombinant Bax inhibitor-1 reconstituted into liposomes. FEBS J. 276(8):2285-91.

34. (77) Kim DH, Ahn T, Jung HC, Pan JG, Yun CH. (2009) Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3. Drug Metab Dispos. 37(5):932-6.

35. (78) Ahn T, Yun CH, Chae HZ, Kim HR, Chae HJ. (2009) Refolding and reconstitution of human recombinant Bax inhibitor-1 into liposomes from inclusion bodies expressed in Escherichia coli. Protein Expr Purif. 66(1):35-8.

36. (79) Seo JH, Lim JC, Lee DY, Kim KS, Piszczek G, Nam HW, Kim YS, Ahn T, Yun CH, Kim K, Chock PB, Chae HZ. (2009) A novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: N alpha -terminal acetylation of human peroxiredoxin II. J Biol Chem. 284(20):13455-13465.

37. (80) Ahn T, Yun CH. (2009) Ca(2+)-induced stimulation of the membrane binding of Escherichia coli SecA and its association with signal peptides of secretory proteins. Arch Biochem Biophys. 486(2):125-131.

38. (81) Lee SY, Gong EY, Hong CY, Kim KH, Han JS, Ryu JC, Chae HZ, Yun CH, Lee K. (2009) ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation. Free Radic Biol Med. 47(11):1591-600.

39. (82) Ahn T, Ko JH, Cho EY, Yun CH. (2009) Conformational change of Escherichia coli signal recognition particle Ffh is affected by the functionality of signal peptides of ribose-binding protein. Mol Cells. 27(6):681-7.

40. (83) Ahn T, Chi YT, Yun CH. (2009) Effect of Nonlamellar-Prone Lipids on Protein Encapsulation in Liposomes. Macromolecular Research 17(12):965-962.

41. (84) Ahn T, Yun CH. (2009) Effects of epitope sequence tandem repeat and proline incorporation on polyclonal antibody production against cytochrome 1A2 and 3A4. BMB Rep. 42(7):418-20.

42. (85) Jang HH, Kim DH, Ahn T, Yun CH. (2010) Functional and conformational modulation of human cytochrome P450 1B1 by anionic phospholipids. Arch Biochem Biophys. 493(2):143-50.

43. (86) Kim​ DH, Kim KH, Kim D, Jung HC, Pan JG, Chi YT, Ahn T, Yun CH. (2010) Oxidation of human cytochrome P450 1A2 substrates by Bacillus megaterium cytochrome P450 BM3. J Mol Catal B: Enzym 63(3-4):179-187.

44. (87) Park SH, Kim DH, Kim D, Kim DH, Jung HC, Pan JG, Ahn T, Kim D, Yun CH. (2010) Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation. Drug Metab Dispos. 38(5):732-739.

45. (88) Jang HH, Jamakhandi AP, Sullivan SZ, Yun CH, Hollenberg PF, Miller GP. (2010) Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners. Biochim Biophys Acta. 1804(6):1285-1293.

46. (89) Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP (2010) Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. .Chem Res Toxicol. 23(5):939-945.

47. (90) Yim SK, Kim DH, Jung HC, Pan JG, Kang HS, Ahn T, Yun CH. (2010) Surface display of heme- and diflavin-containing cytochrome P450 BM3 in Escherichia coli: a whole cell biocatalyst for oxidation. J Microbiol Biotechnol. 20(4):712-717.

48. (91) Ueng YF, Tsai CC, Lo WS, Yun CH. (2010) Induction of hepatic cytochrome P450s by the herbal medicine Sophora flavescens extract in rats: impact on the elimination of theophylline. Drug Metab Pharmacokinet. 25(6):560-567.

49. (92) Ahn T, Yun CH, Kim HR, Chae HJ. (2010) Cardiolipin, phosphatidylserine, and BH4 domain of Bcl-2 family regulate Ca2+/H+ antiporter activity of human Bax inhibitor-1. Cell Calcium. 47(4):387-396.

50. (93)Dr. Thien-Kim Le,Jinhyun Kim,Dr. Ngoc Anh Nguyen,Dr. Thi Huong Ha Nguyen,Dr. Eun-Gene Sun,Su-Min Yee,Prof. Dr. Hyung-Sik Kang,Prof. Dr. Soo-Jin Yeom,Prof. Dr. Chan Beum Park,Prof. Dr. Chul-Ho Yun (2021) Solar-Powered Whole-Cell P450 Catalytic Platform for C-Hydroxylation Reactions (First published: 04 June 2021) https://doi.org/10.1002/cssc.202100944