Microtubules/Actin filaments mimicking reaction cycle based assemblies
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 890659-CYCLOTUBES.
This Marie CURIE individual fellowship funded project awarded to Dr. Nishant Singh at the University of Strasbourg with Pr. Thomas M. Hermans (https://www.thomashermans.com/wp/) deals with preparation of persistent cyclic structures using D,L- amino acid sequence which can be zipped and unzipped to/from their self-assembled nanotubular structures using relatively mild chemical fuels. We further aim to create prolonged assembled and disassembled states of such cyclic peptides based tubular assemblies under constant fuel addition and waste removal. We also aim to microtubules/actin orthogonal assemblies driven by heterogenous nucleation to create complex 3 dimensional nanostructures based on aldehyde-saccharide based molecules which lead to self-sorted hydrogels using chemical fuels.
microtubules/actin like fueled assemblies
Microtubules like fueled assemblies based on Cyclic peptides.
Schematic of cyclic peptide based tubular assemblies and their proposed behavior under fuels
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