Vorgeschlagene klinische Studien / Suggested clinical trials

Im Folgenden finden Sie Vorschläge für klinische Studien, die Sie mit dem CTrO-Editor modellieren könnten. Sie können jedoch auch eine Studie auswählen, die nicht in dieser Liste enthalten ist.

The following are suggestions of clinical trials that you can model with CTrO-Editor. However, you can also select a study not included in this list.


  • Type 2 Diabetes Mellitus:

  • Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal/bolus (glargine/lispro) therapy. Rosenstock et al., 2008. PMID 17934150.

  • Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. Ahrén et al., 2007. PMID 17992639.

  • Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, randomized, open-label, parallel-group comparison. Robbins et al., 2007. PMID 18158076.

  • A 52-week, multinational, open-label, parallel-group, noninferiority, treat-to-target trial comparing insulin detemir with insulin glargine in a basal-bolus regimen with mealtime insulin aspart in patients with type 2 diabetes. Hollander et al., 2008. PMID 19108786.

  • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Raz et al., 2008. PMID 18194595.


  • Glaucoma:

  • A comparison of the efficacy and tolerability of brimonidine and latanoprost in adults with open-angle glaucoma or ocular hypertension: a three-month, multicenter, randomized, double-masked, parallel-group trial. DuBiner et al., 2001. PMID 11813932.

  • Randomized clinical trial of latanoprost and unoprostone in patients with elevated intraocular pressure. Jampel et al., 2002. PMID 12470755.

  • Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma. Rismanchian et al., 2008. PMID 18327364.

  • An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure. Hatanaka et al.,2008. PMID 19092465.

  • Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertension.

  • Miglior et al., 2009. PMID 20019759.

  • Atrial Fibrillation:

  • Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation. Patel et al., 2011. PMID 21830957.

  • Dabigatran versus Warfarin in Patients with Atrial Fibrillation. Connolly et al., 2009. PMID 19717844.

  • Apixaban versus Warfarin in Patients with Atrial Fibrillation. Granger et al., 2011. PMID 21870978.

  • Edoxaban versus Warfarin in Patients with Atrial Fibrillation. Giugliano et al., 2013. PMID 24251359.

  • Edoxaban versus enoxaparin–warfarin in patients undergoing cardioversion of atrial fibrillation (ENSURE-AF): a randomised, open-label, phase 3b trial. Goette et al., 2016. PMID 27590218.