Investigator profile

Research articles

equal contributions, * corresponding author

  1. Bhandari, B. K., Lim, C. S., Remus, D. M., Chen, A., van Dolleweerd, C., & Gardner, P. P. (2021). Protein yield is tunable by synonymous codon changes of translation initiation sites. PLoS Comput. Biol. .17(10): e1009461. 📥

  2. Lim, C. S., Weinstein, B. N., Roy, S. W., & Brown, C. M. (2021). Analysis of fungal genomes reveals commonalities of intron loss or gain and functions in intron-poor species. Mol. Biol. Evol., 38, 4166-4186 📥

  3. Bhandari, B. K., Lim, C. S., & Gardner, P. P. (2021). TISIGNER.com: web services for improving recombinant protein production. Nucleic Acids Res., 49, W654-W661. 📥

  4. Lim, C. S., Sozzi, V., Littlejohn, M., Yuen, L. K. W., Betz-­Stablein, B., Luciani, F., Revill, P. A., & Brown, C. M. (2021). Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes. Microb. Genom., 7, 000492. 📥

  5. Tan, C. Y., Lim, C. S., Liew, S. M., Abd Halim, A. A., & Tayyab, S. (2021). Lysine modification of human serum albumin and its effect on protein conformation and nalidixic acid binding. J. Indian Chem. Soc., 98, 100031.

  6. Bhandari, B. K., Gardner, P. P. & Lim, C. S.* (2020). Solubility-Weighted Index: fast and accurate prediction of protein solubility. Bioinformatics, 36, 4691-4698. 📥

  7. Chapman, L. M., Spies, N., Pai, P., Lim, C. S., Carroll, A., Narzisi, G., Watson, C. M., Proukakis, C., Clarke, W. E., Nariai, N., Dawson, E., Jones, G., Blankenberg, D., Brueffer, C., Xiao, C., Kolora, S. R. R., Alexander, N., Wolujewicz, P., Ahmed, A., Smith, G., Shehreen, S., Wenger, A. M., Salit, M., & Zook, J. M. (2020). A crowdsourced set of curated structural variants for the human genome. PLoS Comput. Biol., 16, e1007933. 📥

  8. Tan, L. P., Tan, G. W., Sivanesan, V. M., Goh, S. L., Ng, X. J., Lim, C. S., Kim, W. R., Mohidin, TBM, Dali, N. S. M., Ong, C. S. H., Wong, C. Y., Sawali, H., Yap, Y. Y, Hassan, F., Pua, K. C., Koay, C. E., Ng, C. C., Khoo, A. S. B., & the Malaysian Nasopharyngeal Carcinoma Study Group. (2019). Systematic comparison of plasma EBV DNA, anti-EBV antibodies and miRNA levels for early detection and prognosis of nasopharyngeal carcinoma. Int. J. Cancer, 146, 2336-2347. 📥

  9. Toh, T. H., Lim, K. S., Ng, C. C., Idris, I., Ahmad, S. B., Lim, T. T., Looi, I., Tan, A. H., Chan, C. K., Lim, C. S., & Tan, C. T. (2019). Genotypic and phenotypic variation of CADASIL among Chinese, Indians and Rungus in Malaysia. Neurosci. Res. Notes, 2, 1–11. 📥

  10. Lim, C. S., Wardell, S. J. T., Kleffmann, T., & Brown, C. M. (2018). The exon-intron gene structure upstream of the initiation codon predicts translation efficiency. Nucleic Acids Res., 46, 4575–4591. 📥

  11. Lim, C. S., & Brown, C. M. (2016). Hepatitis B virus nuclear export elements: RNA stem-loop α and β, key parts of the HBV post-transcriptional regulatory element. RNA Biol., 13, 743–747. 📥

  12. Lim, K. S., Tan, A. H., Lim, C. S., Chua, K. H., Lee, P. C., Ramli, N., Rajahram, G. S., Hussin, F. T., Wong, K. T., Bhattacharjee, M. B., & Ng, C. C. (2015). R54C Mutation of NOTCH3 Gene in the First Rungus Family with CADASIL. PLoS One, 10, e0135470. 📥

  13. Lim, C. S., Goh, S. L., Kariapper, L., Krishnan, G., Lim, Y. Y., & Ng, C. C. (2015). Inclusion bodies of recombinant Epstein–Barr virus capsid antigen p18 as potential immobilized antigens in enzyme immunoassays for detection of nasopharyngeal carcinoma. Clin. Chim. Acta, 448, 206–210.

  14. Lim, C. S., Goh, S. L., Krishnan, G., & Ng, C. C. (2014). Recombinant production of Epstein-Barr virus BZLF1 trans-activator and characterization of its DNA-binding specificity. Protein Expr. Purif., 95, 8–12.

  15. Lim, C. S., Krishnan, G., Sam, C. K., & Ng, C. C. (2013). On optimizing the blocking step of indirect enzyme-linked immunosorbent assay for Epstein-Barr virus serology. Clin. Chim. Acta, 415, 158–161.

Reviews and commentaries

  1. Lim, C. S., & Brown, C. M. (2018). Know your enemy: Successful bioinformatic approaches to predict functional RNA structures in viral RNAs. Front. Microbiol., 8, 2582. 📥

  2. Lim, C. S. & Brown, C. (2017). A new class of ribozyme from hepatitis B virus. FEBS J., 284: 1182–1183. 📥

Preprints

  1. Bhandari, B. K., Gardner, P. P., & Lim, C. S.* (2020), Razor: annotation of signal peptides from toxins. bioRxiv, DOI: https://doi.org/10.1101/2020.11.30.405613 📥