Embedded Files
(*, co-first; #, corresponding; _, lab member)
Representative papers
Xue, M.*; Kim, C. S.*; Healy, A. R.; Wernke, K. M.; Wang, Z.; Frischling, M. C.; Shine, E. E.; Wang, W.; Herzon, S. B.#; Crawford, J. M.#
Structure elucidation of colibactin and its DNA cross-links.
Science 2019, 365, eaax2685. (dx.doi.org/10.1126/science.aax2685)
Kim, C. S.; Gatisos, A.; Cuesta, S.; Yick, C. L.; Wei, Z.; Chen, H.; Russell, R. M.; Shine, E. E.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Palm, N. W.; Sperandio, V.; Crawford, J. M.#
Characterization of autoinducer-3 structure and biosynthesis in E. coli.
ACS Cent. Sci. 2020, 6, 197-206. (doi.org/10.1021/acscentsci.9b01076)
Ha, Y. J.*; Hwang, S. J.*; Hong, S.*; Kim, J.*; Kim, M.; Lee, G. S.; Lee, S. H.; Kim, H.; Lee, B. S.; An, H. I.; Kim, K. H.; Lee, W.#; Lee, H.-J.#; Kim, C. S.#
Erythromycin stress upregulates anti-angiogenic metabolites in the gut bacterium, Aneurinibacillus aneurinilyticus.
J. Am. Chem. Soc. 2025, 147(19), 16459-16470. (https://pubs.acs.org/doi/10.1021/jacs.5c03174).
Full Papers
2025
108. Maungprasert, S.; Berghe, W. V.; Kim, C. S.; Laphookhieo, S.; Somsuan, K.; Aluksanasuwan, S.; Morchang, A.; Deachathai, S.#
Anticancer Activity of Garcinia xanthochymus Crude Extracts Against Human Cancer Cells: In Vitro Evaluation in MDA-MB-231, Huh-7, A549, and SW480 Cell Lines.
Trends Sci. 2025, 22(10), 10842. (https://doi.org/10.48048/tis.2026.10842)
107. Lee, S. H.; Ham, S. L.; Oh, K.; Park, H.; Kang, Y.-S.; Yang, T.-J.; Kim, T.; Kim, J.; Lee, G. S.; Lee, M.-J.; Park, J.-B.#; Kim, C. S.#; Kim, N. Y.#
Discovery to engineering of mycotoxin deoxynivalenol degrading enzymes based on the specialized glyoxalase I.
Adv. Sci. 2025, 12(29), e02914. (https://doi.org/10.1002/advs.202502914)
106. Lee, W. M.*; Ahn, S.-y.*; Lee, G. S.*; Park, I.; Kim, J.; Lee, S. H.; Lee, S.#; Kim, C. S.#
Discovery and biosynthesis of indole-functionalized metabolites from the human blood bacterium, Paracoccus sanguinis, and their anti-skin aging activity.
J. Nat. Prod. 2025, 88(5), 1120–1129. (https://doi.org/10.1021/acs.jnatprod.4c01354)
– Highlighted in
1) ACS News (2025.06.05.) (https://www.acs.org/pressroom/presspacs/2025/june/possible-anti-aging-compounds-found-in-blood-bacteria.html)
2) Scienmag (2025.06.05.) (https://scienmag.com/scientists-discover-potential-anti-aging-compounds-in-blood-bacteria)
3) Others (https://acs.altmetric.com/details/177823750/news)
105. Le, T. T.*; Tran, S. H.*; Lee, S.; Kang, S. W.; Kim, J. H.; Park, K.; Kim, C. S.; Kim, M.; Kang, K.; Jung, S. H.#
Furan acids from nutmeg and their neuroprotective and antineuroinflammatory activities.
J. Agric. Food Chem. 2025, 73(18), 11080–11093. (https://pubs.acs.org/doi/full/10.1021/acs.jafc.5c02528)
104. Kim, M.*; Kim, J.*; Lee, G. S.*; Olinare, P. D. B.; Airan, Y.; Chow, J. L.; Park, J.; Jeong, Y.; Park, J.; Chait, B. T.; Herzon, S. B.; Kim, C. S.#; Kang, J. Y.#
Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin.
Structure 2025, 33(7), p1208-1223.e5. (https://doi.org/10.1016/j.str.2025.04.017)
103. Ha, Y. J.*; Hwang, S. J.*; Hong, S.*; Kim, J.*; Kim, M.; Lee, G. S.; Lee, S. H.; Kim, H.; Lee, B. S.; An, H. I.; Kim, K. H.; Lee, W.#; Lee, H.-J.#; Kim, C. S.#
Erythromycin stress upregulates anti-angiogenic metabolites in the gut bacterium, Aneurinibacillus aneurinilyticus.
J. Am. Chem. Soc. 2025, 147(19), 16459-16470. (https://pubs.acs.org/doi/10.1021/jacs.5c03174)
– Highlighted in
1) BRIC (2025.05.13.) (https://www.ibric.org/bric/trend/results-of-research.do?mode=view&articleNo=9971095&article.offset=0&articleLimit=15&beforeMode=research-result#!/list)
2) 성균관대학교 (2025.05.13.) (https://www.skku.edu/skku/campus/skk_comm/news.do?mode=view&articleNo=127178)
3) 성균관대학교 약학대학 (2025.05.13.) (https://pharm.skku.edu/bbs/board.php?bo_table=student&wr_id=992)
4) 조선일보 (2025.05.13.) (https://www.chosun.com/economy/science/2025/05/13/CFWVXLMLI7TZ5A47HVEOZKGR2M)
5) 한국대학신문 (2025.05.13.) (https://news.unn.net/news/articleView.html?idxno=578730)
6) 뉴데일리 (2025.05.13.) (https://biz.newdaily.co.kr/site/data/html/2025/05/13/2025051300386.html)
102. Ha, M. T.; Le, T. T.; Lee, D. Y.; Kim, C. S.; Youn, U. J.; Kim, S. H.#; Kim, J. A.#; Min, B. S.#
Chemical constituents of Himantormia lugubris collected from Antarctica and their PTP1B and α-glucosidase inhibitory activities.
Phytochem. Lett. 2025, 66, 91-99. (https://doi.org/10.1016/j.phytol.2025.02.009)
101. Park, S.; Jeon, W.-J.; Lee, Y.; Lim, C. L.; Lee, E.; Oh, H. B.; Lee, G. S.; Kwon, O. H.; Ryu, B.; Cho, Y.-J.; Kim, C. S.; Yoon, S.-i.; Chung, J. M.; Cho, H.#
A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli.
Proc. Natl. Acad. Sci. U.S.A. 2025, 122(4), e2418854122. (https://doi.org/10.1073/pnas.2418854122)
100. Choi, Y.; Kim, Y.; Cha, J. W.; Lee, G. S.; Pham, H. T.; Ngo, M. T.; Kim, S.; Kim, C. S.; Kang, K. B.#
Iodide Enhances the Production of Pseurotin D over Pseurotin A by Inverting the Preference for the SN2 versus the SN2′ Product in the Final Nonenzymatic Step.
J. Nat. Prod. 2025, 88(1), 199-204. (https://doi.org/10.1021/acs.jnatprod.4c01128)
2024
99. Lee, J. -H.*; Hwang, S. J.*; Ham, S. L.; Kim, J.; Bang, H. J.; Park, J. -S.; Jang, H. -H.; Kim, T. Y.; Park, J. W.; Seo, Y. R.; Kim, B. S.; Kim, G. S.; Lee, H. -J.#; Kim, C. S.#
Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice.
ACS Omega 2024, 9(43), 43875-43883. (https://pubs.acs.org/doi/10.1021/acsomega.4c06923)
98. Le, T. T.; Ha, M. T.; Lee, G. S.; Nguyen, V. P.; Kim, C. S.#; Kim, J. A.#; Min, B. S.#
Terpenoids and steroids from aerial parts of Achillea alpina L. as PTP1B inhibitors: kinetic analysis and molecular docking studies.
Phytochemistry 2025, 229, 114269. (https://doi.org/10.1016/j.phytochem.2024.114269)
97. Kim, S.*; Park, I.*; Kim, M.; Lee, G. S.; Kim, C. S.#; Han, S.#
Synthesis and Structure Revision of Securingine E.
Org. Lett. 2024, 26(34), 7161-7165. (https://doi.org/10.1021/acs.orglett.4c02556)
96. Le, T. T.*; Kim, J.*; Kang, T. K.; Lee, W. -B.; Kim, M.; Kim, C. S.#; Jung, S. H.#
Neolignans and Diarylnonanoid Derivatives with Anti-inflammatory Activity from Myristica fragrans Houtt. Seeds.
ACS Omega 2024, 9(32), 35170-35181. (https://doi.org/10.1021/acsomega.4c05649)
95. Kim, M.*; Park, S.*; Kang, G.*; Jang, Y. S.*; Kim, K. H.#; Han, S.#; Kim, C. S.#
Natural product anticipation via chemical synthesis: Discovery of two new Securinega alkaloids
iScience 2024, 27, 110495. (https://doi.org/10.1016/j.isci.2024.110495)
94. Kim, J.*; Hwang, S. J.*; Lee, G. S.*; Lee, J. R.; An, H. I.; Im, H. S.; Kim, M.; Lee, S. -S.; Lee, H. -J.#; Kim, C. S.#
Collagenase and tyrosinase inhibitory compounds from fish gut bacteria Ruegeria atlantica and Pseudoalteromonas neustonica.
ACS Omega 2024, 9(32), 34259-34267. (https://doi.org/10.1021/acsomega.3c09585)
– Highlighted in
1) ACS News (2024.09.05.) (https://www.acs.org/pressroom/presspacs/2024/september/how-fish-guts-might-play-a-role-in-future-skin-care-products.html)
2) kormedi.com (2024.09.26.) (https://kormedi.com/1723793)
3) The K Beauty Science (2025.02.11.) (https://www.thekbs.co.kr/news/articleView.html?idxno=13140)
93. Kim, H. R.*; Lee, G. S.*; Park, I.*; Kim, C. S.#
Indole derivatives and a diketopiperazine from Chromobacterium violaceum.
Nat. Prod. Sci. 2024, 30(2), 130-134. (https://doi.org/10.20307/nps.2024.30.2.130)
92. Lee, J. R.; Hwang, S. J.; Choi, Y.; Kim, J.; Lee, G. S.; Lee, B. S.; Kim, K. H.; Kang, K. B.; Lee, H.-J.; Kim, C. S.#
Structural diversification of pyrazinone metabolites via spontaneous oxa-Michael addition in Staphylococcus xylosus.
J. Nat. Prod. 2024, 87(7), 1181-1187. (https://doi.org/10.1021/acs.jnatprod.4c00252)
91. Lee, D. Y.; Kim, J.; Lee, G. S.; Park, S.; Song, J.; Lee, B. S.; Lee, S. R.; Kim, K. H.; Kim, C. S.#
Characterization of chemical interactions between clinical drugs and the oral bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES.
ACS Chem. Biol. 2024, 19(4), 973-980. (IF: 4.0) (https://doi.org/10.1021/acschembio.3c00798)
2023
90. Lee, T. H.*; Yoon, D. H.*; Park, K. J.; Hong, S. -M.; Kim, M.; Kim, S. Y.; Kim, C. S.#; Lee, K. R.#
Neurotrophic phenolic glycosides from the roots of Armoracia rusticana.
Phytochemistry 2023, 216, 113886. (IF: 3.8) (https://doi.org/10.1016/j.phytochem.2023.113886)
89. Park, K. J.; Khan, Z.; Hong, S. -M.; Kim, S. Y.; Lee, K. R.#; Kim, C. S.#
Neurotrophic neolignans of Pinus koraiensis twigs.
Fitoterapia 2023, 170, 105664. (IF: 3.4) (https://doi.org/10.1016/j.fitote.2023.105664)
88. Fahmy, N. M.*; El-din, M. I. G.*; Salem, M. M.; Rashedy, S. H.; Lee, G. S.; Jang, Y. S.; Kim, K. H.; Kim, C. S.#; El-Shazly#, M.; Fayez, S.
Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking.
Mar. Drugs 2023, 21, 404. (IF: 5.4) (https://doi.org/10.3390/md21070404)
87. Ham, S. L.; Lee, T. H.; Kim, K. J.; Kim, J. H.; Hwang, S. J.; Lee, S. H.; Yu, J. S.; Kim, K. H.; Lee, H.-J.; Lee, W.; Kim, C. S.#
Discovery and biosynthesis of imidazolium antibiotics from the probiotic Bacillus licheniformis.
J. Nat. Prod. 2023, 86(4), 850-859. (IF: 5.1) (https://doi.org/10.1021/acs.jnatprod.2c01032)
– selected as a Cover Page
86. Lee, J. R.*; Park, K. J.*; Ham, S. L.; Kim, J.; Kim, C. S.#
Structure revision of anti-inflammatory indole alkaloids with a 1,2-benzisoxazole ring.
ACS Omega 2023, 8(15), 13967-13970. (IF: 4.1) (https://doi.org/10.1021/acsomega.3c00408)
85. Lee, D. J.; Hong, S. -M.; Yoon, D. H.; Ham, S. L.; Kim, J.; Kim, S. Y.; Choi, S. U.; Kim, C. S.#; Lee, K. R.#
Triterpenoids from the leaves of Abies koreana and their biological activities.
Phytochemistry 2023, 208, 113594. (IF: 3.8) (https://doi.org/10.1016/j.phytochem.2023.113594)
84. Kim, H. R.; Kim, J.; Yu, J. S.; Lee, B. S.; Kim, K. H.; Kim, C. S.#
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis.
Arch. Pharm. Res. 2023, 46(1), 35-43. (IF: 6.7) (doi.org/10.1007/s12272-022-01424-z)
83. Lee, D. Y.*; Park, K. J.*; Subedi, L,; Lee, G. S.; Lee, J. -H.; Lee, W. -M.; Choi, S. U.; Hong, S. -M.; Kim, S. Y.; Kim, C. S.#
Anti‐Inflammatory, neurotrophic, and cytotoxic oxylipins Isolated from Chaenomeles sinensis twigs.
Antioxidants 2023, 12(2), 284. (IF: 7.0) (doi.org/10.3390/antiox12020284)
2022
82. Gatsios, A.*; Kim, C. S.*; York, A. G.; Flavell, R. A.; Crawford, J. M.#
Cellular Stress-Induced Metabolites in Escherichia coli.
J. Nat. Prod. 2022, 85(11), 2626-2640. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.2c00706)
81. Lee, T. H.*; Ham, S. L.*; Lee, D. Y.; Lee, J. R.; Kim, J.; Kim, C. S.#
Structure revision of balsamisides A–D and establishment of an empirical rule for distinguishing four classes of biflavonoids
J. Nat. Prod. 2022, 85(10), 2461-2467. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.2c00694)
– selected as a Cover Page
80. Vu K. N.; Ha, M. T.; Ha, Y. J.; Kim, C. S.; Gal, M.; Ngo, Q. -M. T.; Kim, J. A.; Woo, M. H.; Lee, J. -H.; Min, B. S.#
Structures and antiosteoclastogenic activity of compounds isolated from edible lotus (Nelumbo nucifera Gaertn.) leaves and stems
Fitoterapia 2022, 162, 105294. (IF: 3.4) (doi.org/10.1016/j.fitote.2022.105294)
79. Kim, D. H.; Ham, S. L.; Khan, Z.; Kim, S. Y.; Choi, S. U.; Kim, C. S.; Lee, K. R.#
Terpenoids from Glechoma hederacea var. longituba and their biological activities.
Beilstein J. Org. Chem. 2022, 18, 555–566. (IF: 2.7) (doi.org/10.3762/bjoc.18.58)
78. Ha, Y. J.; Lee, T. H.; Subedi, L.; Kim, H. R.; Moon, G.; Kim, S. Y.; Kim, C. S.#
Anti-inflammatory and neurotrophic 2H-1-benzopyran derivatives of Chaenomeles sinensis.
Nat. Prod. Sci. 2022, 28(1), 1-5. (doi.org/10.20307/nps.2022.28.1.1)
77. Lee, T. H.; Hong, S. M.; Yoon, D. H.; Kim, S. Y.; Kim, C. S.; Lee, K. R.#
Procyanidins and phlobatannins from the twigs of Rosa multiflora and their neuroprotective activity.
J. Nat. Prod. 2022, 85(4), 917-926. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.1c01033)
76. Park, J. E.; Lee, T. H.; Ham, S. L.; Subedi, L.; Hong, S. M.; Kim, S. Y.; Choi, S. U.; Kim, C. S.#; Lee, K. R.#
Anticancer and anti-neuroinflammatory constituents isolated from the roots of Wasabia japonica.
Antioxidants 2022, 11(3), 482. (IF: 7.0) (doi.org/10.3390/antiox11030482)
75. Ha, M. T.; Lee, T. H.; Kim, C. S.; Prajapati, R.; Kim, J. A.; Choi, J. S.; Min, B. S.#
PTP1B and α-glucosidase inhibitory activities of the chemical constituents from Hedera rhombea fruits: Kinetic analysis and molecular docking simulation
Phytochemistry 2022, 197, 113100. (IF: 3.8) (doi.org/10.1016/j.phytochem.2022.113100)
2021
74. Lee, T. H.; Subedi, L.; Ha, Y. J.; Moon, G.; Kim, S. Y.; Kim, C. S.#
Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity
Phytochemistry 2021, 192, 112962. (IF: 3.8) (doi.org/10.1016/j.phytochem.2021.112962)
73. Park, K. J.*; Suh, W. S.*; Yoon, D. H.; Kim, C. S.; Kim, S. Y.; Lee, K. R.#
Phenolic constituents from twigs of Aleurites fordii and their biological activities.
Beilstein J. Org. Chem. 2021, 17, 2329-2339. (IF: 2.7) (doi.org/10.3762/bjoc.17.151)
72. Quan, K. T.; Park, I.; Kim, C. S.; Yoshida, W.; Ferreira, D.; Thuong, P. T.; Kim, Y. H.; Na, M.#; Oh, J.#
Configurational assignment of a flexible benzo[g]isochromene stereodiad from Rubia philippinensis and inhibition of soluble epoxide hydrolase activity
J. Nat. Prod. 2021, 84(9), 2594-2599. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.1c00037)
71. Kim, C. S.#; Turocy, T.; Moon, G.; Shine, E. E.; Crawford, J. M.#
Escherichia coli-derived γ-lactams and structurally related metabolites are produced at the intersection of colibactin and fatty acid biosynthesis.
Org. Lett. 2021, 23(17), 6895-6899. (IF: 5.2) (doi.org/10.1021/acs.orglett.1c02461)
70. Vu, N. K.; Ha, M. T.; Kim, C. S.; Gal, M.; Kim, J. A.; Woo, M. H.; Lee, J.-H.; Min, B. S.#
Structural characterization of prenylated compounds from Broussonetia kazinoki and their antiosteoclastogenic activity.
Phytochemistry 2021, 188, 112791. (IF: 3.8) (doi.org/10.1016/j.phytochem.2021.112791)
69. Choi, Y. S.; Yoon, D. H.; Kim, C. S.; Lee, K. R.#
Stilbene oligomers from the stems of Parthenocissus tricuspidata and their potential anti-neuroinflammatory and neuroprotective activity.
Tetrahedron Lett. 2021, 71, 153027. (IF: 1.8) (doi.org/10.1016/j.tetlet.2021.153027)
68. Gatsios, A.; Kim, C. S.; Crawford, J. M.#
Escherichia coli small molecule metabolism at the host-microbe interface.
Nat. Chem. Biol. 2021, 17, 1016-1026 (IF: 14.8) – review (doi.org/10.1038/s41589-021-00807-5)
67. Schorn, M. A.*; Verhoeven, S.*; Ridder, L; … Kim, C. S.; … Dorrestein, P. C.#; Medema, M. H.#; van der Hooft, J. J. J.#
A community resource for paired genomic and metabolomic data mining.
Nat. Chem. Biol. 2021, 17(2), 363-368. (IF: 14.8) – comment (doi.org/10.1038/s41589-020-00724-z)
66. Lee, S.*; Kim, C. S.*; Yu, J. S.; Kang, H.; Yoo, M. J.; Youn, U, J.; Ryoo, R.; Bae, H. Y.; Kim, K. H.#
Ergopyrone, a styrylpyrone-fused steroid with a hexacyclic 6/5/6/6/6/5 skeleton from a mushroom Gymnopilus orientispectabilis.
Org. Lett. 2021, 23(9), 3315-3319. (IF: 5.2) (doi.org/10.1021/acs.orglett.1c00790)
– selected as a Cover Page
65. Kim, D. H.; Subedi, L.; Kim, H. R.; Choi, S. U.; Kim, S. Y.; Kim, C. S.#
Phenolic constituents of Chinese Quince twigs (Chaenomeles sinensis Koehne) and their anti-neuroinflammatory, neurotrophic, and cytotoxic activities.
Antioxidants 2021, 10(4), 551. (IF: 7.0) (doi.org/10.3390/antiox10040551)
64. Cha, J. M.*; Lee, T. H.*; Subedi, L.; Ha, Y. J.; Kim, H. R.; Kim, S. Y.; Choi, S. U.; Kim, C. S.#
Isolation and structural characterization of four diastereomeric lignan glycosides from Abies holophylla and their neuroprotective activity.
Tetrahedron 2021, 77, 131735. (IF: 2.1) (doi.org/10.1016/j.tet.2020.131735)
2020
63. Cha, J. M.*; Kim, D. H.*; Subedi, L.; Khan, Z.; Choi, S. U.; Kim, S. Y.; Kim, C. S.#
Chemical constituents of Chaenomeles sinensis twigs and their biological activity.
Beilstein J. Org. Chem. 2020, 16, 3078-3085. (IF: 2.7) (doi.org/10.3762/bjoc.16.257)
62. Kim, C. S.#; Oh, J.; Lee, T. H.
Structure elucidation of small organic molecules by contemporary computational chemistry methods.
Arch. Pharm. Res. 2020, 43(11), 1114-1127. (IF: 6.7) – review (doi.org/10.1007/s12272-020-01277-4)
61. Yu, J. S.; Li, C.; Kwon, M.; Oh, T.; Lee, T. H.; Kim, D. H.; Ahn, J. S.; Ko, S. K.; Kim, C. S.; Cao, S.#; Kim, K. H.#
Herqueilenone A, a unique rearranged benzoquinone-chromanone from the Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729.
Bioorg. Chem. 2020, 105, 104397. (IF: 5.1) (doi.org/10.1016/j.bioorg.2020.104397)
60. Cha, J. M.; Yoon, D.; Kim, S. Y.; Kim, C. S.; Lee, K. R.#
Neurotrophic and anti-neuroinflammatory constituents from the aerial parts of Coriandrum sativum.
Bioorg. Chem. 2020, 105, 104443. (IF: 5.1) (doi.org/10.1016/j.bioorg.2020.104443)
59. Lee, T. H.; Suh, W. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.; Kim, C. S.#
Three new oleanane-type triterpenoidal glycosides from Impatiens balsamina and their biological activity.
Plants-Basel 2020, 9(9), 1083. (IF: 4.5) (doi.org/10.3390/plants9091083)
58. Park, H. B.*; Wei, Z.*; Oh, J.; Xu, H.; Kim, C. S.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.#; Crawford, J. M.#
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.
Nat. Microbiol. 2020, 5(11), 1319-1329 (IF: 28.3) (doi.org/10.1038/s41564-020-0763-4)
57. Vu, N. K.*; Kim, C. S.*; Ha, M, T.; Ngo, Q. -M. T.; Park, S. E.; Kwon, H.; Lee, D.; Choi, J. S.; Kim, J. A.; Min, B. S.
Antioxidant and antidiabetic activities of flavonoid derivatives from the outer skins of Allium cepa L.
J. Agric. Food Chem. 2020, 68(33), 8797-8811 (IF: 6.1) (doi.org/10.1021/acs.jafc.0c02122)
56. Wernke, K. M.; Xue, M.; Tirla, A.; Kim, C. S.; Crawford, J. M.; Herzon, S. B.#
Structure and bioactivity of colibactin.
Bioorg. Med. Chem. Lett. 2020, 30(15), 127280. (IF: 2.7) – review (doi.org/10.1016/j.bmcl.2020.127280)
55. Kim, C. S.*; Li, J. –H.*; Barco, B.; Wei, Z.; Park, H. B.; Wang, R.; Wyche, T. P.; Piizzi, G.; Clay, N. K.; Crawford, J. M.#
Cellular stress upregulates indole signaling metabolites in E. coli.
Cell Chem. Biol. 2020, 27(6), 698-707.e7 (IF: 8.6) (doi.org/10.1016/j.chembiol.2020.03.003)
54. Kim, C. S.; Gatisos, A.; Cuesta, S.; Yick, C. L.; Wei, Z.; Chen, H.; Russell, R. M.; Shine, E. E.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Palm, N. W.; Sperandio, V.; Crawford, J. M.#
Characterization of autoinducer-3 structure and biosynthesis in E. coli.
ACS Cent. Sci. 2020, 6(2), 197-206. (IF: 18.2) (doi.org/10.1021/acscentsci.9b01076)
– Highlighted in
1) ACS Cent. Sci. (2020, 6, 93-96, https://pubs.acs.org/doi/10.1021/acscentsci.0c00033)
2) Yale News (https://westcampus.yale.edu/news/scientists-zero-endgame-nasty-bacteria?refresh=2)
3) Phys Org News (https://phys.org/news/2020-01-scientists-endgame-nasty-bacteria.html)
4) Health Canal (https://www.healthcanal.com/infections/249907-scientists-zero-in-on-endgame-for-nasty-bacteria.html)
5) 한국을 빛내는 사람들 (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=61274&idauthorid=30903&ttype=0&ksr=1&FindText=%EA%B9%80%EC%B6%A9%EC%84%AD)
53. Kim, M.; Ha, M. T.; Kim, C. S.; Park, S. E.; Kim, J. A.; Woo, M. H.; Choi, J. S.; Min, B. S.#
Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation.
Bioorg. Med. Chem. Lett. 2020, 30(8), 127049. (IF: 2.7) (doi.org/10.1016/j.bmcl.2020.127049)
2019
52. Xue, M.*; Kim, C. S.*; Healy, A. R.; Wernke, K. M.; Wang, Z.; Frischling, M. C.; Shine, E. E.; Wang, W.; Herzon, S. B.#; Crawford, J. M.#
Structure elucidation of colibactin and its DNA cross-links.
Science 2019, 365(6457), eaax2685. (IF: 56.9) (dx.doi.org/10.1126/science.aax2685)
– Highlighted in
1) Nat. Chem. Biol. (2019, 15, 933, https://www.nature.com/articles/s41589-019-0373-8)
2) Chemical & Engineering News (https://cen.acs.org/biological-chemistry/microbiome/Researchers-elucidate-colibactin-structure/97/i32)
3) Yale News (https://westcampus.yale.edu/yale-scientists-zero-atomic-driver-tumor-formation)
4) 한국을 빛내는 사람들 (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=59269&idauthorid=30903&ttype=0&ksr=1&FindText=%EA%B9%80%EC%B6%A9%EC%84%AD)
51. Healy, A. R.; Wernke, K. M.; Kim, C. S.; Lees, N. R.; Crawford, J. M.#; Herzon, S. B.#
Synthesis and reactivity of precolibactin 886.
Nat. Chem. 2019, 11(10), 890-898. (IF: 21.8) (doi.org/10.1038/s41557-019-0338-2)
– Highlighted in Nat. Chem. (2019, 11, 867-869)
50. Lee, S. R.; Lee, D.; Eom, H. J.; Rischer, M.; Ko, Y. –J.; Kang, K. S.; Kim, C. S.; Beemelmanns, C.; Kim, K. H.#
Hybrid polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and their putative biosynthetic origin.
Mar. Drugs 2019, 17(11), 606. (IF: 5.4) (doi.org/10.3390/md17110606)
49. Kim, D. H.; Kim, C. S.; Subedi, L.; Kim, S. Y.; Lee, K. R.#
Alkaloids of NIRAM, natural dye from Polygonum tinctorium, and their anti-inflammatory activities.
Tetrahedron Lett. 2019, 60(41), 151130. (IF: 1.8) (doi.org/10.1016/j.tetlet.2019.151130)
48. Park, K. J.; Kim, C. S.; Khan, Z.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Securinega alkaloids from the twigs of Securinega suffruticosa and their biological activities.
J. Nat. Prod. 2019, 82(5), 1345-1353. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.9b00142)
2018
47. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Rare thioglycosides from the roots of Wasabia japonica.
J. Nat. Prod. 2018, 81(9), 2129-2133. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.8b00570)
46. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Structural characterization of terpenoids from Abies holophylla using computational and statistical methods and their biological activities.
J. Nat. Prod. 2018, 81(8), 1795-1802. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.8b00245)
45. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Two new phenolic glycosides from Sorbus commixta.
Chem. Pharm. Bull. 2018, 66(8), 839-842. (IF: 1.7) (doi.org/10.1248/cpb.c18-00280)
44. Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
A new phenolic compound from Salix glandulosa.
Heterocycles 2018, 96(5), 931-942. (IF: 0.6) (doi.org/10.3987/COM-18-13892)
43. Park, K. J.; Kim, D. H.; Kim, C. S.; Oh, J.; Subedi, L.; Son, M. W.; Choi, S. Z.; Kim, S. Y.; Lee, K. R.#
Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis.
Tetrahedron Lett. 2018, 59(50), 4380-4383. (IF: 1.8) (doi.org/10.1016/j.tetlet.2018.10.057)
42. Oh, J.; Quan, K. T.; Lee, J. S.; Park. I.; Kim, C. S.; Ferreira, D.;Thuong, P. T.; Kim, Y. H.; Na, M.#
NMR-based investigation of hydrogen bonding in a dihydroanthracen-1(4H)one from Rubia philippinensis and its soluble epoxide hydrolase inhibitory potential.
J. Nat. Prod. 2018, 81(11), 2429-2435. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.8b00441)
2017
41. Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Bioactive triterpenoids from the twigs of Chaenomeles sinensis.
J. Nat. Prod. 2017, 80(4), 1134-1140. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.7b00111)
40. Kim, C. S.; Bae, M.; Oh, J.; Subedi, L.; Suh, W. S.; Choi, S. Z.; Son, M. W.; Kim, S. Y.; Choi, S. U.; Oh, D.–C.; Lee, K. R.#
Anti-neurodegenerative biflavonoid glycosides from Impatiens balsamina.
J. Nat. Prod. 2017, 80(2), 471-478. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.6b00981)
39. Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Holophyllane A: A triterpenoid possessing an unprecedented B-nor-3,4-seco-17,14-friedo-lanostane architecture from Abies holophylla.
Sci. Rep. 2017, 7, 43646. (IF: 4.6) (doi.org/10.1038/srep43646)
38. Kim, C. S.; Oh, J.; Suh. W. S.; Jang, S. W.; Subedi, L.; Kim, S. Y.; Lee, K. R.#
Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities.
Phytochem. Lett. 2017, 22, 255-260. (IF: 1.7) (doi.org/10.1016/j.phytol.2017.09.014)
37. Triparthi, P.*; Shine, E. E.*; Healy, A. R.; Kim, C. S.; Herzon, S. B.; Bruner, S. D.#; Crawford, J. M.#
ClbS is a cyclopropane hydrolase that confers colibactin resistance.
J. Am. Chem. Soc. 2017, 139(49), 17719-17722. (IF: 15.0) (doi.org/10.1021/jacs.7b09971)
– Highlighted in Nat. Chem. Biol. 2018, 14, 1. and J. Am. Chem. Soc. 2017, 139, 18123.
36. Suh, W. S.; Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Iridoid glycosides from the twigs of Sambucus williamsii var. coreana and their biological activities.
J. Nat. Prod. 2017, 80(9), 2502-2508. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.7b00410)
35. Nguyen, Q. T.*; Lee, D.–H.*; Oh, J.*; Kim, C. S.; Heo, K.–S.; Myung, C.–S.#; Na, M.#
Inhibition of proliferation of vascular smooth muscle cells by cucurbitanes from Momordica charantia.
J. Nat. Prod. 2017, 80(7), 2018-2025. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.7b00151)
34. Lim, S. Y.*; Subedi, L.*; Shin, D.; Kim, C. S.; Lee, K. R.; Kim, S. Y.#
A new neolignan derivative, balanophonin isolated from Firmiana simplex delays the progress of neuronal cell death by inhibiting microglial activation.
Biomol. Ther. 2017, 25(5), 519-527. (IF: 3.7) (doi.org/10.4062/biomolther.2016.224)
2016
33. Kim, C. S.; Subedi, L.; Kwon, O. W.; Park, H. B.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Wasabisides A-E, lignan glycosides from the roots of Wasabia japonica.
J. Nat. Prod. 2016, 79(10), 2652-2657. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.6b00582)
32. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Diterpenes from the trunk of Abies holophylla and their potential neuroprotective and anti-inflammatory activities.
J. Nat. Prod. 2016, 79(2), 387-394. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.5b01053)
31. Kim, C. S.; Suh. W. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Neuroprotective fatty acids from the stem bark of Sorbus commixta.
Lipids 2016, 51(8), 989-995. (IF: 1.9) (doi.org/10.1007/s11745-016-4172-7)
30. Kim, C. S.; Subedi, L.; Kwon, O. K.; Kim, S. Y.; Yeo, E. –J.; Choi, S. U.; Lee, K. R.#
Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis.
Bioorg. Med. Chem. Lett. 2016, 26(2), 351-354. (IF: 2.7) (doi.org/10.1016/j.bmcl.2015.12.004)
29. Kwon, O. K.; Kim, C. S..; Suh, W. S.; Park, K. J.; Cha, J. M.; Choi, S. U.; Kwon, H. C.; Lee, K. R.#
Phenolic compounds from the twigs of Corylopsis coreana uyeki and their cytotoxic activity.
Kor. J. Pharmacogn. 2016, 47(1), 1-6.
28. Suh, W. S.; Lee, S. R.; Kim, C. S.; Moon, E.; Kim, S. Y.; Choi, S. U.; Kang, K. S.; Lee, K. R.; Kim, K. H.#
A new monoacylglycerol from the fruiting bodies of Gymnopilus spectabilis.
J. Chem. Res. 2016, 40(3), 156-159. (IF: 1.4) (doi.org/10.3184/174751916X14546877525997)
27. Son, D.; Kim, C. S.; Lee, K. R.; Park, H.–J.#
Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.
Bioorg. Med. Chem. Lett. 2016, 26(9), 2365-2369. (IF: 2.7) (doi.org/10.1016/j.bmcl.2016.03.010)
2015
26. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Lignan glycosides from the twigs of Chaenomeles sinensis and their biological activities.
J. Nat. Prod. 2015, 78(5), 1174-1178. (IF: 5.1) (doi.org/10.1021/acs.jnatprod.5b00090)
25. Kim, C. S.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. L.; Kim, K. H.#
Cytotoxic and anti-inflammatory disulfide compounds from the fruiting bodies of Boletus pseudocalopus.
J. Antibiot. 2015, 68(6), 414-416. (IF: 3.3) (doi.org/10.1038/ja.2015.2)
24. Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Choi, S. Z.; Son, M. W.; Kim, K. H.; Lee, K. R.#
Two new phenolic compounds from the white flower of Impatiens balsamina.
Phytochem. Lett. 2015, 14, 215-220. (IF: 1.7) (doi.org/10.1016/j.phytol.2015.10.014)
23. Kim, C. S.; Subedi, L.; Park, K. J.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Salicin derivatives from Salix glandulosa and their biological activities.
Fitoterapia 2015, 106, 147-152. (IF: 3.4) (doi.org/10.1016/j.fitote.2015.08.013)
22. Kim, K. H.; Kim, C. S.; Park, Y. J.; Moon, E.; Choi, S. U.; Lee, J. H.; Kim, S. Y.; Lee, K. R.#
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
Bioorg. Med. Chem. Lett. 2015, 25(1), 96-99. (IF: 2.7) (doi.org/10.1016/j.bmcl.2014.11.001)
21. Kim, K. H.; Kang, H. R.; Eom, H. J.; Kim, C. S.; Choi, S. U.; Lee, K. R.#
A new aliphatic alcohol and cytotoxic chemical constituents from Acorus gramineus Rhizomes.
Biosci. Biotechnol. Biochem. 2015, 79(9), 1402-1405. (IF: 1.6) (doi.org/10.1080/09168451.2015.1031079)
20. Jang, S. W.; Suh, W. S.; Kim, C. S.; Kim, K. H.; Lee, K. R.#
A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs.
Arch. Pharm. Res. 2015, 38(11), 1943-1951. (IF: 6.7) (doi.org/10.1007/s12272-015-0610-y)
19. Kim, K. H.; Moon, E.; Cha, J. M.; Lee, S.; Yu, J. S.; Kim, C. S.; Kim, S. Y.; Choi, S. U.; Lee, K. R.#
Antineuroinflammatory and antiproliferative activities of constituents from Tilia amurensis.
Chem. Pharm. Bull. 2015, 63(10), 837-842. (IF: 1.7) (doi.org/10.1248/cpb.c15-00393)
18. Roh, H. J.; Noh, H. J.; Kim, C. S.; Kim, K. H.; Hong, C. Y.; Lee, K. R.#
Phenolic compounds from the leaves of Stewartia pseudocamellia Maxim. and their whitening activities.
Biomol. Ther. 2015, 23(3), 283-289. (IF: 3.7) (doi.org/10.4062/biomolther.2014.140)
2014
17. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, J. Y.; Han, J. Y.; Choi, S. I.; Choi, J. G.; Kim, K. H.; Lee, K. R.#
Phenolic Glycosides from the Twigs of Salix glandulosa.
J. Nat. Prod. 2014, 77(8), 1955-1961. (IF: 5.1) (doi.org/10.1021/np500488v)
16. Kim, C. S.; Shin, B.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Oh, D. C.; Kim, K. H.; Lee, K. R.#
Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla.
Tetrahedron Lett. 2014, 55(47), 6504-6507. (IF: 1.8) (doi.org/10.1016/j.tetlet.2014.10.030)
15. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Five new oxylipins from Chaenomeles sinensis.
Lipids 2014, 49(11), 1151-1159. (IF: 1.9) (doi.org/10.1007/s11745-014-3953-0)
14. Kim, C. S.; Suh, W. S.; Choi, S. U.; Kim, K. H.; Lee, K. R.#
Two new diterpenoids from Thuja orientalis and their cytotoxicity.
Bull. Korean Chem. Soc. 2014, 35(9), 2855-2858. (IF: 1.7) (doi.org/10.5012/bkcs.2014.35.9.2855)
13. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Kim, K. H.; Lee, K. R.#
A new cyclic triterpene saponin from Phyteuma japonicum.
Heterocycles 2014, 89(8), 1913-1922. (IF: 0.6) (doi.org/10.3987/COM-14-13035)
12. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R.#
Flavonoid glycosides from Hosta longipes, their inhibition on NO production, and nerve growth factor inductive effects.
J. Braz. Chem. Soc. 2014, 25(5), 907-912. (IF: 1.4) (doi.org/10.5935/0103-5053.20140060)
11. Kim, C. S.; Kim, K. H.; Lee, K. R.#
Phytochemical constituents of the leaves of Hosta longipes.
Nat. Prod. Sci. 2014, 20(2), 86-90.
10. Cho, H. K.; Kim, C. S.; Woo, K. W.; Lee, K. R.#
A new triterpene saponin from the tubers of Stachys sieboldii.
Bull. Korean Chem. Soc. 2014, 35(5), 1553-1555. (IF: 1.7) (doi.org/10.5012/bkcs.2014.35.5.1553)
9. Cho, H. K.; Kim, C. S.; Suh, W. S.; Kim, K. H.; Lee, K. R.#
Two new triterpene saponins from the tubers of Stachys sieboldii.
Heterocycles 2014, 89(11), 2619-2626. (IF: 0.6) (doi.org/10.3987/COM-14-13103)
2013
8. Kim, C. S., Kim, S. Y.; Moon, E.; Lee, M. K.; Lee, K. R.#
Steroidal constituents from the leaves of Hosta longipes and their inhibitory effects on nitric oxide production.
Bioorg. Med. Chem. Lett. 2013, 23(6), 1771-1775. (IF: 2.7) (doi.org/10.1016/j.bmcl.2013.01.050)
7. Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R.#
Bioactive lignans from the trunk of Abies holophylla.
J. Nat. Prod. 2013, 76(11), 2131-2135. (IF: 5.1) (doi.org/10.1021/np4005322)
6. Kim, C. S.; Oh, J. Y.; Choi, S. U.; Lee, K. R.#
Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity.
Carbohyd. Res. 2013, 381, 1-5. (IF: 3.1) (doi.org/10.1016/j.carres.2013.08.023)
5. Kim, K. H.; Moon, S. R.; Kim, C. S.; Woo, K. W.; Choi, S. U.; Lee, K. R.#
Lignan glucosides from Sinomenium acutum rhizomes.
Biosci. Biotechnol. Biochem. 2013, 77(10), 2144-2147. (IF: 1.6) (doi.org/10.1271/bbb.130445)
4. Lee, S. Y.; Woo, K. W.; Kim, C. S.; Lee, D. U.; Lee, K. R.#
New lignans from the aerial parts of Rudbeckia laciniata.
Helv. Chim. Acta 2013, 96(2), 320-325. (IF: 1.8) (doi.org/10.1002/hlca.201200177)
3. Oh, J. Y.; Kim, C. S.; Lee, K. R.#
C21 Steroidal glycosides from the root of Cynanchum paniculatum.
Bull. Korean Chem. Soc. 2013, 34(2), 637-640. (IF: 1.7) (doi.org/10.5012/bkcs.2013.34.2.637)
2012
2. Kim, C. S.; Choi, S. U.; Lee, K. R.#
Three new diterpenoids from the leaves of Thuja orientalis.
Planta Med. 2012, 78, 485-487. (IF: 2.7) (doi.org/10.1055/s-0031-1298215)
1. Kim, K. H.; Choi, S. U.; Kim, C. S.; Lee, K. R.#
Cytotoxic steroids from the trunk of Berberis koreana.
Biosci. Biotechnol. Biochem. 2012, 76(4), 825-827. (IF: 1.6) (doi.org/10.1271/bbb.110751)
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