Resources

CSE599S: Machine Learning in Computational Biology

Spring 2021 (March 29, 2021 - June 07, 2021)

Reading list

(The list below will be completed soon)

  • Week 1:

  • Week 2:

    • Intro to VAE: here

    • Unsupervised representation of gene expression: here

    • Need for batch effect adjustments? here

  • Week 3:

    • Review: Computational prediction of protein interactions: here

    • ML for protein interactions and functions from sequence: here

  • Week 4:

    • Review on ML guided protein design: here

    • Autofocused oracles for model-based design: here

    • Conditioning by adaptive sampling for robust design: here

  • Week 5:

    • Integrating gene expression an imaging: here and here

  • Week 6:

    • Challenges in 'omics studies of human disease: here

    • Causal Inference from gene expression data: here

    • Other related papers:

      • Clustering on the Unit Hypersphere using von Mises-Fisher Distributions: here

      • Single-cell experimental design: here

  • Week 7:

    • single-cell RNA-seq data modelling & challenges: here and here

  • Week 8:

    • Topics in Cancer Genomics: here and here

  • Week 9:

    • Phenome-scale causal discovery and mendelian randomization: here

  • Week 10:

Preparatory reading for the class:

ML

  • A Course in Machine Learning by Hal DaumĂ© III: http://ciml.info/.

  • Pattern Recognition and Machine Learning by Chris Bishop. (pdf)

Biology

  • Introduction to Molecular Biology (pdf).

  • A lengthy, general resource: Molecular Biology of the Cell v5 (pdf)

Suggested review articles:

  • Opportunities and obstacles for deep learning in biology and medicine (here)