Cord blood

Cord blood is the blood that remains in the placenta and umbilical cord after birth. Cord blood is collected because it contains cell strains that can be used to treat hematopoietic and genetic diseases, such as cancer. Cell therapy companies are increasingly interested in developing genetically modified allogeneic natural killer cells from umbilical cord blood as an alternative to CAR-T cell therapy for rare diseases. Umbilical cord blood consists of all elements of whole blood: erythrocytes, leukocytes, plasma, platelets.

There are some differences in the composition of blood compared to whole blood. For example, cord blood contains more natural killer cells, a lower absolute number of T cells and a higher proportion of immature T cells. However, the interest in cord blood is mainly due to the fact that cord blood also contains different types of cell strains and precursors, mainly hematopoietic stem cells. Certain types of non-hematopoietic cell strains are also present in umbilical cord blood, such as: B. mesenchymal stem cells, but less than in adult bone marrow.

Medical Application

Cord blood is used in the same way as hematopoietic stem cell transplantation to replenish bone marrow stores after radiation therapy for various types of blood cancers and various forms of anemia. The effectiveness is also comparable.

Side Effects of Transplantation

Side effects are similar to those of a hematopoietic stem cell transplant, namely graft-versus-host reactions when the umbilical cord blood comes from a genetically different person and the risk of serious infection during system recovery. To minimize complications during transplantation, transplant rates should be determined; in particular, neutrophils and platelets should be food. Cord blood hematopoietic stem cells are responsible for the development of the baby's blood and immune system. In fact, HSCs are responsible for maintaining the blood and the immune system throughout our lives. For over thirty years, cord blood stem cells have been used for stem cell transplantation to help restore new blood systems and healthy immunity in patients. And because of their unique qualities, researchers are now studying the use of cord blood cells in regenerative medicine research to see if cord blood can stimulate the body's repair system under certain conditions, such as autism.

The blood from the collected umbilical cord is the richest in leukocytes and stem cells. Although stem cells have received a lot of attention, the total number of nuclear cells (CTN) is about 10 times the number of stem cells in a cord blood sample. TNCs are mainly white blood cells or leukocytes; cells of the immune system protect the body. Despite the fact that stem cells make up a tenth of most collections, cord blood is still considered a rich source of hematopoietic stem cells (HSC). HSC is often referred to as the CD34 + marker. Hematopoietic stem cells can be divided into two categories of cells: myeloid cells and lymphoid cells. Myeloid cells continue to form red blood cells, platelets, and other blood cells. Lymphoid cells become B cells and T cells and form the backbone of the immune system. Umbilical cord blood also contains mesenchymal stem cells (MSCs), but there are many more of them in the umbilical cord tissue, which we will talk about a little later. In addition to stem cells, researchers are discovering the special possibilities of using other types of cells to treat certain conditions. Cord blood cables can prevent graft-versus-host disease in stem cell transplants and can reduce the effects of autoimmune diseases such as diabetes, rheumatoid arthritis, and multiple sclerosis. The natural killer blood cells of the umbilical cord also have potential in the future. These cells are planned for clinical trials for specific cancers and tumors. This can make them very good candidates for the treatment of chronic or incurable cancer.

Rescue Potential

After birth, the placenta is usually removed from the umbilical cord with blood. Through scientific research in this area, we are discovering more and more diseases and conditions that can be successfully treated with stem cells in umbilical cord blood.

For the transplant to be a success, the stem cells from the umbilical cord blood must match the patient's tissue type as closely as possible. To give patients the best chance of 'matching', we must therefore save as much cord blood as possible, and we cannot do this without you.

If our trained staff does not collect umbilical cord blood and you have not taken additional steps to collect your own umbilical cord blood, the placenta containing the cord blood will be properly disposed of for the hospital.

Rich in Stem Cells

Cord blood is blood that remains in the placenta and umbilical cord after the birth of a baby. It is rich in blood strains similar to those found in the bone marrow and can be used to treat many types of cancer, immune deficiencies and genetic diseases. Stem cells are the stem cells of the body. Hematopoietic stem cells (called hematopoietic stem cells) are found in umbilical cord blood. We call these cells non-specialized, meaning they have the ability to grow in the parts of the blood that the patient's body needs; Be it red blood cells, white blood cells or platelets.

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