Cardiopulmonary and respiratory sequelae of preterm birth

Cardiopulmonary outcomes in adults with a history of preterm birth are only beginning to be identified and understood. Our lab has produced some of the first data in this population identifying cardiopulmonary adult outcomes and examining the mechanisms responsible for those outcomes. We have identified normal pulmonary gas exchange efficiency, but abnormal airway and pulmonary vascular responses to exercise. The significance, innovation and impact of this work is evidenced by invitations to collaborate in this area with other groups (MacLean et al., Thorax, 2016), editorials on our work by leaders in the field of respiratory limitations to exercise in patients with obstructive lung disease (O’Donnell Annals ATS, 2014), citations in very high impact reviews (Islam et al., AJRCCM 2015; Bolton et al., Thorax, 2015) and invitation to speak and participate in NIH-sponsored workshops on this topic.

Most significant publications in this area:

Duke, J.W., J.E. Elliott, S.S. Laurie, K.M. Beasley, T.S. Mangum, J.A. Hawn, I.M. Gladstone & Lovering, A.T. Pulmonary gas exchange efficiency at rest and during exercise breathing normoxic and hypoxic gas in adults born very preterm with low diffusion capacity. J Appl Physiol 117: 473-481, 2014. PMID: 25085889

Lovering, A.T., J.E. Elliott, S.S. Laurie, K.M. Beasley, C.E. Gust, T.S. Mangum, I.M. Gladstone and J.W. Duke. Ventilatory and sensory responses in adult survivors of preterm birth and broncho-pulmonary dysplasia with reduced exercise capacity. Annals ATS 11(10) 1528-1537, 2014. PMID: 25380058.

Laurie, SS, Elliott, JE, Beasley, KM, Mangum, TS, Goodman, RD, Duke, JW, Gladstone, IM, and Lovering, AT. Exaggerated increase in pulmonary artery pressure during exercise in adults born preterm. Am J Respir Crit Care Med, 2018. DOI: 10.1164/rccm.201704-0740LE. PMID: 28885857.

J.W. Duke, A. Zidron, I.M. Gladstone & A.T. Lovering. Alleviating mechanical constraints to ventilation with heliox improves exercise endurance in adult survivors of very preterm birth.THORAX 74(3):302-304, 2019. PMID:30217953