Publications

Seo E*, Park S*, Park I, Bhin J#.
Decoding Genomic Rearrangements in Cancer: Path to Novel Driver Discovery
Molecules and Cells (Accepted)

Yemelyanenko J*, Bhin J*, Burg E, van der Burg E, Drenth AP, Lee JK, Lutz C, Dorner L, Wientjens E, Klarenbeek S, Song JY, Moon H, Annunziato S, Proost N, Siteur B, Ross JS,  van de Ven M, Tellingen O, Ganesan S, Wessels LFA, Zingg D, Jonkers J.
C-terminal truncation and fusion partner determine oncogenicity of FGFR3
Cancer Research (Accepted)

Zingg D, Lin CC, Yemelyanenko J, Wieteska L, Kas SM, Bleijerveld OB, Chao X, Bhin J, Lutz C, Wientjens E, Klarenbeek S, Zanetti G, Annunziato S, Siteur B, van der Burg E, Drenth AP, van de Ven M, Wessels LFA, Altelaar M, Ladbury JE, Jonkers J.
The C-terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2
Cancer Research 2025 Jun 24 

Lutz C, Chao X, de Klein B, Bhin J, Badoux M, Eijkman T, Nikolakopoulos AP, Hutten SJ, Proost N, Siteur B, van de Ven M, Song JY, van Rheenen J, Morgner J, Prekovic S, Jonkers J.
Large-Scale Characterization of Orthotopic Cell Line-Derived Xenografts Identifies TGF-β Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness
Cancer Research 2025 Apr 30 

Bhin J*, Yemelyanenko J*, Klarenbeek S, Opdam M, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van de Ven M, Peters D, Linn SC, Boven E, Altelaar M, Jonkers J#, Zingg D#, Wessels LFA#
MYC is a clinically significant determinant of mTOR inhibitor resistance in breast cancer
J. Exp. Med. 2023 Nov 6;220(11) [한빛사 논문]

Bhin J*, Paes Dias M*, Gogola E*, Rolfs F, Piersma SR, de Bruijn R, de Ruiter J, van den Broek B, Duarte AA, Sol W, van der Heijden I, Bakker L, Kaiponen TS, Lieftink C, Morris B, Beijersbergen RL, van de Ven M, Jimenez CR, Wessels LFA#, Rottenberg S#, Jonkers J#
Multi-omics analysis reveals distinct non-reversion mechanisms of PARP inhibitor resistance in BRCA1- versus BRCA2-deficient mammary tumors
Cell Rep. 2023 May; 42(5):112538 [한빛사 논문] 

Zimmerli D*, Brambillasca CS*, Talens F*, Bhin J, Linstra R, Romanens L, Bhattacharya A, Joosten SEP, Da Silva AM, Padrao N, Wellenstein MD, Kersten K, de Boo M, Roorda M, Henneman L, de Bruijn R, Annunziato S, van der Burg E, Drenth AP, Lutz C, Endres T, van de Ven M, Eilers M, Wessels LFA, de Visser KE, Zwart W, Fehrmann RSN#, van Vugt MATM#, Jonkers J#.
MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling
Nat Commun. 2022 Nov 2;13(1):6579

Zingg D*, Bhin J*, Yemelyanenko J*, Kas SM*, Rolfs F, Lutz C, Lee JK, Klarenbeek S, Silverman IM, Annunziato S, Chan CS, Piersma SR, Eijkman T, Badoux M, Gogola E, Siteur B, Sprengers J, de Klein B, de Goeij-de Haas RR, Riedlinger GM, Ke H, Madison R, Drenth AP, van der Burg E, Schut E, Henneman L, van Miltenburg MH, Proost N, Zhen H, Wientjens E, de Bruijn R, de Ruiter JR, Boon U, de Korte-Grimmerink R, van Gerwen B, Féliz L, Abou-Alfa GK, Ross JS, van de Ven M, Rottenberg S, Cuppen E, Chessex AV, Ali SM, Burn TC, Jimenez CR, Ganesan S#, Wessels LFA#, Jonkers J#.
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Nature. 2022 Aug;608(7923):609-617 [한빛사 논문]

Paes Dias M*, Tripathi V*, van der Heijden I, Cong K, Manolika EM, Bhin J, Gogola E, Galanos P, Annunziato S, Lieftink C, Andújar-Sánchez M, Chakrabarty S, Smith GCM, van de Ven M, Beijersbergen RL, Bartkova J, Rottenberg S, Cantor S, Bartek J, Ray Chaudhuri A#, Jonkers J#.
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
Mol Cell. 2021 Nov 18;81(22):4692-4708.

Klarenbeek S*, Doornebal CW*, Kas SM, Bonzanni N, Bhin J, Braumuller TM, van der Heijden I, Opdam M, Schouten PC, Kersten K, de Bruijn R, Zingg D, Yemelyanenko J, Wessels LFA, de Visser KE#, Jonkers J#.
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system
Oncoimmunology. 2020 Feb 12;9(1):1724049.

Annunziato S*, Lutz C*, Henneman L, Bhin J, Wong K, Siteur B, van Gerwen B, de Korte-Grimmerink R, Zafra MP, Schatoff EM, Drenth AP, van der Burg E, Eijkman T, Mukherjee S, Boroviak K, Wessels LF, van de Ven M, Huijbers IJ, Adams DJ, Dow LE, Jonkers J.
In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer
EMBO J. 2020 Mar 2;39(5):e102169.

Mun DG*, Bhin J*, Kim S*, Kim H*, Jung JH*, Jung Y, Jang YE, Park JM, Kim H, Jung Y, Lee H, Bae J, Back S, Kim SJ, Kim J, Park H, Li H, Hwang KB, Park YS, Yook JH, Kim BS, Kwon SY, Ryu SW, Park DY, Jeon TY, Kim DH, Lee JH, Han SU, Song KS, Park D, Park JW, Rodriguez H, Kim J, Lee H, Kim KP, Yang EG#, Kim HK#, Paek E#, Lee S#, Lee SW#, Hwang D#.
Proteogenomic characterization of human early-onset gastric cancer
Cancer Cell. 2019 Jan 14;35(1):111-124.e10 [한빛사 논문]

Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung BH, Hwang D, Kim MS, Park KS, Macedo MP, White M, Jones J, Kim YB.
Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
J Clin Invest. 2018 Dec 3;128(12):5335-5350. 

Barazas M, Annunziato S, Pettitt SJ, de Krijger I, Ghezraoui H, Roobol SJ, Lutz C, Frankum J, Song FF, Brough R, Evers B, Gogola E, Bhin J, van de Ven M, van Gent DC, Jacobs JJL, Chapman R, Lord CJ, Jonkers J#, Rottenberg S#.
The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells
Cell Rep. 2018 May 15;23(7):2107-2118.

Bin BH*#, Bhin J*, Takaishi M, Toyoshima KE, Kawamata S, Ito K, Hara T, Watanabe T, Irié T, Takagishi T, Lee SH, Jung HS, Rho S, Seo J, Choi DH, Hwang D, Koseki H, Ohara O, Sano S, Tsuji T, Mishima K, Fukada T.
Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248 [한빛사 논문]

Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression
PLoS Genet. 2017 Aug 30;13(8):e1006950.

Kim K*, Boo K*, Yu YS, Oh SK, Kim H, Jeon Y, Bhin J, Hwang D, Kim KI, Lee JS, Im SS, Yoon SG, Kim IY, Seong JK, Lee H, Fang S#, Baek SH#.
RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
Nat Commun. 2017 Jul 31;8(1):162.

Bin BH*#, Bhin J*, Seo J, Kim SY, Lee E, Park K, Choi DH, Takagishi T, Hara T, Hwang D, Koseki H, Asada Y, Shimoda S, Mishima K, Fukada T#.
Requirement of zinc transporter SLC39A7/ZIP7 for dermal development to fine-tune endoplasmic reticulum function by regulating protein disulfide isomerase
J Invest Dermatol. 2017 Aug;137(8):1682-1691.

Jeong HS*, Bhin J*, Joon Kim H, Hwang D#, Ryul Lee D, Kim KS#.
Transcriptional regulatory networks underlying the reprogramming of spermatogonial stem cells to multipotent stem cells
Exp Mol Med. 2017 Apr 14;49(4):e315.

Bin BH, Kim ST, Bhin J, Byoun K, Lee TR, Cho EG.
The synergistic effect of maltose enhances the anti-melanogenic activity of acarbose
Arch Dermatol Res. 2017 Apr;309(3):217-223.

Bin BH, Bhin J, Kim NH, Lee SH, Jung HS, Seo J, Kim DK, Hwang D, Fukada T, Lee AY, Lee TR, Cho EG.
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis
J Invest Dermatol. 2017 Apr;137(4):874-883.

Bin BH, Kim ST, Bhin J, Lee TR, Cho EG.
The development of sugar-based anti-melanogenic agents.
Int J Mol Sci. 2016 Apr 16;17(4):583.

Bin BH, Kim DK, Kim NH, Choi EJ, Bhin J, Kim ST, Gho YS, Lee AY, Lee TR, Cho EG.
Fibronectin-containing extracellular vesicles protect melanocytes against ultraviolet radiation-induced cytotoxicity
J Invest Dermatol. 2016 May;136(5):957-966.

Kim Y*, Nam HJ*, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H, Koh GY, Baek SH.
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
Nat Commun. 2016 Jan 13;7:10347.

Bhin J*, Jeong HS*, Kim JS, Shin JO, Hong KS, Jung HS, Kim C, Hwang D#, Kim KS#.
PGC-enriched miRNAs control germ cell development
Mol Cells. 2015 Oct;38(10):895-903.

Bin BH, Bhin J, Yang SH, Shin M, Nam YJ, Choi DH, Shin DW, Lee AY, Hwang D, Cho EG, Lee TR.
Membrane-associated transporter protein (MATP) regulates melanosomal pH and influences tyrosinase activity
PLoS One. 2015 Jun 9;10(6):e0129273.

Boo K*, Bhin J*, Jeon Y, Kim J, Shin HJ, Park JE, Kim K, Kim CR, Jang H, Kim IH, Kim VN, Hwang D#, Lee H#, Baek SH#.
Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells.
Nat Commun. 2015 Apr 10;6:6810 [한빛사 논문]

Lee KA*, Kim B*, Bhin J, Kim DH, You H, Kim EK, Kim SH, Ryu JH, Hwang D, Lee WJ.
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.
Cell Host Microbe. 2015 Feb 11;17(2):191-204.

Bin BH, Bhin J, Yang SH, Choi DH, Park K, Shin DW, Lee AY, Hwang D, Cho EG, Lee TR.
Hyperosmotic stress reduces melanin production by altering melanosome formation
PLoS One. 2014 Aug 29;9(8):e105965.

Bin BH, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR, Fukada T.
Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins
EMBO Mol Med. 2014 Aug;6(8):1028-42.

Kim H, Lee JM, Lee G, Bhin J, Oh SK, Kim K, Pyo KE, Lee JS, Yim HY, Kim KI, Hwang D, Chung J, Baek SH.
DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis
Mol Cell. 2011 Dec 9;44(5):797-810.

Lee JS, Kim Y, Bhin J, Shin HJ, Nam HJ, Lee SH, Yoon JB, Binda O, Gozani O, Hwang D, Baek SH.
Hypoxia-induced methylation of a pontin chromatin remodeling factor
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13510-5.

Yun SJ, Byun K, Bhin J, Oh JH, Nhung le TH, Hwang D#, Lee B#.
Transcriptional regulatory networks associated with self-renewal and differentiation of neural stem cells
J Cell Physiol. 2010 Nov;225(2):337-47.