Computational NeuroBiology Lab 

Synaptic signaling in normal function and pathological states

Motivated by the synapses' vital role in brain function and the experimental constraints that may pose a barrier to a complete understanding of synaptic function, we construct in silico models of synapses with unprecedented biophysical and morphological detail. This modeling framework lets us address fundamental questions about information processing at synapses and make quantitative predictions. Using this framework, we can also make sense of existing high-dimensional data that span multiple levels of organization and are sourced from diverse experiments. Such ‘postdictions' can lead to general operating principles of brain function and can be valuable contributions to theory in Neuroscience. Our overarching objective is to comprehend the molecular signaling mechanisms that underlie synaptic transmission, synaptic plasticity, and their interplay with higher-level cognitive processes.