This conference is intended as the second meeting after the one which has previously taken place in the Institut d’Etudes Scientifiques de Cargèse from 18-23 April 2016. The first meeting has been a success, because it has gathered scientists working on different aspects of evolutionary and protein biology, ranging from modeling to experiments, including statistical physicists, bioinformaticians, biochemists, and evolutionary biologists. It has initiated several collaborations and has shown that the interdisciplinarity is practically possible, and cross-fertilization of the different fields is necessary to develop this research area. The field of protein coevolution and evolutionary sequence modeling has known since then an important expansion and advances into several directions, including impressive results combining coevolution and machine learning. It is important to update the previous meeting, to collect the fruit of the last meeting and stimulate new exchanges between the involved scientists.

Main topics will include: sequence analysis and coevolutionary sequence modeling ■ structural prediction of protein ■ prediction of protein-protein interactions ■ genome-wide sequence landscapes ■ molecular evolutionary biology ■ statistical physics of inverse problems and statistical inference ■ machine learning for sequence-structure-function in proteins.