Schedule

18:30-19:00  Arrival and registration: Grande Bibliothèque - BAnQ

Room: Salle M. 425

19:00 –22:00 Welcome reception

08:30 – 09:00   Arrival and registration (Grande Bibliothèque - BAnQ)

Room: M.425

09:00 – 09:15   Opening Remarks

                     Room: Auditorium

09:15 – 10:30   Session 1: Translation and cotranslational folding I

Room: Auditorium. Chair: Alex Palazzo

09:15               Synonymous Codons and mRNA Modifications in the Control of Ribosome Progression

Marina V. Rodnina

09:40          Programmed ribosome collisions enable homeostatic control of selenoprotein production during oxidative stress

Joshua Mendell

10:05               Protein entanglement misfolding determines divergent fates: proteosomal degradation or persistence in near-native misfolded states

Ed O'Brien

10:20               Combinatorial and library of synonymous mutants in E. coli ligases to reveal positional and epistatic determinants by folding efficiency

Felipe Otsuka

10:35 -11:05            Coffee Break

11:05- 12:35            Session 2: Translation and cotranslational folding

                               Room: Auditorium. Chair: Patricia Clark

11:05              Mechanism of codon usage-dependent translation initiation and evasion of host codon usage control by human viruses

Yi Liu

11:30              Plasmid-Wide Effects of Synonymous Substitutions on Gene Expression in E. coli

Patricia Clark

11:55              Use of RAPPL ribosome isolation for functional and structural studies of translation and new insights into peptidyl-tRNA drop off

                       Sergej Djuranovic

12:10              Methylated eEF1A drives tumor growth and drug resistance via selective decoding

                       Ivan Topisirovic

12:25              Synonymous codon usage and translational responses to low sulfur stress in plants

Naoyuki Sotta

12:40-14:00  Lunch

14:00 - 15:45 Session 3: mRNA metabolism I

Room: Auditorium. Chair: Yi Liu

14:00               DDX6 clamps to purine-rich RNA to control ribosome traffic and co-translational assembly

Martin Bushell

14:25               Intronic polyadenylation generates functional RNAs that operate independently of protein output

Hong Cheng

14:50               Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism

Qi Xie

15:15               Codon-dependent regulation of mRNA translation and stability by two paralog vertebrate-specific RNA-binding proteins

Seyed Mehdi Jafarnejad

15:30                A population genomics approach resolves how transcript properties jointly control translation and mRNA stability

Daniel Pollard

15:45 – 16:15   Coffee Break

16:15 – 18:00   Session 4: RNA metabolism II

Room: Auditorium. Chair: Grzegorz Kudla

16:15              Human DHX29 detects non-optimal codon usage to regulate mRNA stability

Osamu Takeuchi

16:40               Codon optimization introduces widespread cryptic splicing that can be predicted by deep learning models

Fernando Bellido Molias

17:00              RQC Components as Regulators of Cellular Adaptation to Stress

Maria Vera Ugalde

17:25               Investigating the mRNA surveillance mechanism in the AU-rich transcriptome of malaria parasites

Slavica Pavlovic Djuranovic

17:40              Deciphering the code: codons, codon-codon interactions, amino acids, and peptide bonds regulate mRNA stability

Haejeong Lee

18:00-21:00  Dinner and Poster Session (odd number: 7-8pm. Even number: 8-9pm)

                     Room: Hall

09:00 - 10:45 Session 5: RNA metabolism III

Room: Auditorium. Chair: Marina Rodnina

09:00              Transcription, Replication, and Recombination Shape Local Mutation and Sequence Variation at Human TSSs

Fanny Pouyet

09:25              Cellular introns recruit RNA-binding proteins to protect against HUSH-mediated epigenetic silencing

Paul J Lehner

9:50                ARS variants and mistranslation - when misreading the genetic code causes disease

                       Ilka Heinemann

10:15              Wobble-regulated reading of codons is discriminated by ribosome proofreading

Ya-Ming Hou

10:30              Mapping tRNA modifications using Nanopore direct RNA sequencing

David Garcia

10:45 – 11:15   Coffee Break

11:15 – 12:35   Session 6: Computational and new approaches I

Room: Auditorium. Chair: Maria Vera Ugalde

11:15              Protein language models reveal evolutionary constraints on codon choice

Liana Lareau

11:40              Learning the Language of Codon Translation with CodonFM

Sara Rabhi

12:05              A foundation model to study the molecular principles of codon usage

                       Susanne Bornelöv

   12:20              Structural basis for start codon selection by eIF5-mimic proteins

                       Ximena Zottig

12:35-14:00  Lunch

14:00 – 15:35   Session 7: Computational and new approaches II

Room: Auditorium. Chair: Grzegorz Kudla

14:00              Codon usage function in translation

Yitzhak Pilpel

14:25              Codon Optimization in Next-Generation Oncolytic Virus Design

Anton A. Komar

14:50              GC content at the 5' end of human protein-coding genes is shaped by collisions between the replication fork and RNA polymerase II in CpG islands

Tina Qiu

15:05              Uncovering tissue-specific tRNA regulation and function in animal development

Jake Klemm

15:20              Di-codon organization links tRNA modifications to cancer cell proteome composition

                       Ola Larsson

15:35-16:00  Coffee break

16:00-16:45  Keynote Speech: eIF4E1 and 4EHP (eIF4E2) among many mRNA 5’ cap-binding proteins with disparate functions

                           Nahum Sonenberg, McGill University

                           Chair: Yi Liu

16:50 – 18:10   Session 8: Computational and new approaches III

                     Room: Auditorium. Chair:  Anton Komar

  16:50          An Integrative Approach to Predictive Modeling of Translation

                       Can Cenik

     17:15            Genetic code as the organizer of RNA-protein interaction networks.

Bojan Zagrovic

17:40         RARS1 integration into the multisynthetase complex is necessary for mammalian brain development

Haissi Cui

17:55              A tRNA regulatory nexus of cell-state dependent protein expression

Britt van Abeelen

18:10-21:00  Dinner and Poster Session

                     Room: Hall