Friday, May 24  2024

Saturday, May 25 2024

09:00 – 09:15 Arrival and registration (11 Queen Street)

Room: Foyer

09:15 – 09:30 Opening remarks

Room: Auditorium

09:30 - 10:45 Session: mRNA metabolism I

Room: Auditorium

Chair/s: Grzegorz Kudla

09:30 Inverse dynamics of translation at rare arginine codons link the Not4 E3 ligase and the Puf3 Pumilio family RNA binding protein to protein homeostasis

Martine Collart

09:55 Dengue virus preferentially uses human and mosquito non-optimal codons

Ariel Bazzini

10:20 Codon usage regulates translation initiation

Olivia Rissland

10:45 - 11:15 Coffee break

11:15 - 12:35 Session: mRNA metabolism II

Room: Auditorium

Chair/s: Ariel Bazzini

11:15 The codon usage-dependent gene expression is largely due to nuclear effects

Yi Liu

11:40 How mRNA nuclear export allows you to live with a genome filled with junk DNA

Alex Palazzo

12:05 Investigating the translational regulation imposed by the CCR4-NOT associated RNA helicases DDX6 and eIF4A2

Joseph Waldron

12:20 An unbiased screen identifies the PAXT connection as a modifier of rare codon-dependent expression

Taylor Niehoff

12:35 - 14:00 Lunch

14:00 - 15:45 Session: Translation and cotranslational folding I

Room: Auditorium

Chair/s: Yi Liu

14:00 Structural basis of the translating ribosome as a mRNA monitoring device

Roland Beckmann

14:25 EMBO Young Investigator Lecture: The dynamics and functional impact of tRNA repertoires in differentiation and development

Danny Nedialkova 

14:50 Full speed ahead: determinants and consequences of translation elongation rate

Liana Lareau

15:15 Dichotomous nature of codon-dependence of mRNA stability as a function of coding sequence length and polysome propensity

Attila Becksei

15:30 Integrated analysis of tRNA sequence modification and charging by nanopore sequencing

Jay Hesselberth

15:45 – 16:15 Coffee break

16:15 – 18:00 Session: Translation and cotranslational folding II

Room: Auditorium

Chair/s: Danny Nedialkova

16:15 Sequence context effects on suppression of premature termination codons

Zoya Ignatova

16:40 Deciphering and Engineering hidden coding-region codes

Tamir Tuller

17:05 Regulation of translation by site-specific ribosomal RNA methylation and distinct codon bias signatures in tri-lineage cell differentiation

Martin Jansson

17:30 Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough

Leos Valasek

17:45 Regulation of Magnaporthe oryzae Infection through tRNA Thiolation: Impact on Translation and Codon Usage

Zhipeng Zhou

18:00 - 21:00 Dinner and Poster Session #1 (odd numbers)

Room: Foyer

Sunday, May 26 2024

09:30 - 10:50 Session: Translation and cotranslational folding III

Room: Auditorium

Chair/s: Edward O'Brien

09:30 Synonymous codon substitutions modulate transcription and translation of a divergent upstream gene via antisense RNA

Patricia Clark

09:55 How changes in translation rhythm shape protein structures

Marina Rodnina

10:20 Ideal codon usage of Drosophila CREBB endows its structure and function for memory formation

Pei-Wen Fu

10:35 Impact of synonymous mutations on cotranslational folding using a human factor-based reconstituted cell-free translation system

Hideki Taguchi

10:50 - 11:20 Coffee break

11:20 – 12:25 Session: Computational and new approaches I

Room: Auditorium

Chair/s: Patricia Clark

11:20 Small but Powerful: The Impact of tRNAs and miRNAs on Proteostasis

Michal Linial

11:45 Protein misfolding, disease, and attempting to detect synonymousmutation effects on cancer cell growth profiles

Edward O’Brien

12:10 The diverse roles of ribosomal frameshifting by codon usage

Yunkun Dang

12:25 - 14:00 Lunch

14:00 – 15:45 Session: Computational and new approaches II

Room: Auditorium

Chair/s: Laurent Duret

14:00 Synonymous codon choice affects mis-translation and survival of Escherichia coli under drug treatment

Yitzhak Pilpel

14:25 Fitness effects of synonymous mutations in yeast: an update

Jianzhi Zhang

14:50 Insufficient evidence for non-neutrality of synonymous mutations

Craig Kaplan

15:15 Deciphering the code: codons, codon-codon interactions, amino acids, and peptide bonds regulate mRNA stability

Haejeong Lee

15:30 Predicting gene sequences with AI to study evolutionarily selected codon usage patterns

Rachel Kolodny

15:45 – 16:15 Coffee break

16:15 – 18:00 Session: Molecular evolution of codon usage biases I

Room: Auditorium

Chair/s: Tzachi Pilpel

16:15 A landscape of coordinated changes of tRNA modifications for codon usage and protein homeostasis

Ya-Ming Hou

16:40 Codon usage variation, selection, and evolution across the fungal subphylum Saccharomycotina

Abigail LaBella

17:05 Codon Pair-Specific Translation Defects Trigger Ribosome Associated Quality Control to Avoid Proteotoxic Stress

Sebastian Leidel

17:20 Therapeutic Implications of Synonymous Gene Recoding of ADAMTS13: Insights into mechanisms controlling protein biogenesis and activity

Chava Kimchi-Sarfaty

17:35 Quantifying and Contextualizing the Importance of Nonsense Errorson the Evolution of codon usage bias

Michael Gilchrist

18:00 – 21:00 Dinner and Poster Session #2 (even numbers)

Room: Foyer

09:30 - 10:35 Session: Molecular evolution of codon usage biases II

Room: Auditorium

Chair/s: Michal Linial

09:30 Why is selection for translationally optimal codons so scarce in metazoans?

Laurent Duret

09:55 Synonymous, cinnaunimus: The evolution and effects of silent mutations

Deepa Agashe

10:20 Role of synonymous mutations in adaptive evolution

Andrei Papkou

10:35 – 11:05 Coffee break

11:05 - 12:10 Session: Emerging methods and mechanisms I

Room: Auditorium

Chair/s: Deepa Agashe

11:05 Deep learning for sequence-to-expression prediction

Diego Oyarzún

11:30 Good endings and new beginnings: Improving microbial protein production through varying (un)translated 5’ and 3’ regions of a gene, and screening for better variants by proteomics

Charlotte Koster

11:55 Translation of the non-canonical genetic code of Blastocrithidia nonstop

Zdenek Paris

12:10 – 13:10 Lunch

13:10 – 14:30 Session: Emerging methods and mechanisms II

Room: Auditorium

Chair/s: Zoya Ignatova

13:10 Deciphering the regulatory code through multiplex assays of variant effects

Grzegorz Kudla

13:35 AI for Optimized mRNA Sequence Design

Liang Huang

14:00 Less is more: Slow-codon windows boost mRNA resilience against RNA interference

Sophia Rudorf

14:15 Deep single synonymous scanning in E. coli protein used to study expression levels and cell stress

Felipe Otsuka

14:30 – 15:00 Discussion on future conferences

End of the conference