The CLPTM1 gene family has shown to not be particularly associated with oralfacial clefts. Rather, CLPTM1 has been associated with T-cell development and CLPTM1L has been associated with cisplatin resistance. CLPTM1L has been implicated in cancer. Overexpression of CLPTM1L can cause some cancer cells to become resistant to cisplatin mediated apoptosis. This prevents the cells from dying, and leads to rapid proliferation of cancer cells. A common cancer that over expresses CLPTM1L is lung cancer. [4] Also, CLPTM1L may be related to the TERT gene which encodes for telomerase. [5] Today, little is still known about these two genes as the full structure and function of both have yet to be fully elucidated. This project serves to examine the structure of the genes, the function of the genes, and their interactions with other genes.