Research

Warburg Effect

Warburg effect states the shift in the energy generation metabolism of cancerous cells from oxidative phosphorylation to glycolysis. Nowadays, this statement has regained attention mostly with recent findings about protein acetylation as one of the key post-translational modifications involved in metabolic pathways.

Pathway of Warburg effect

Sodium Borate (NaB)

Sirtuins, which function as NAD+-dependent deacetylase or ADP ribosyltransferase, are indicated in the regulation of cell survival and longevity in response to the changes in cellular energy state. Alteration in NADH/NAD+ levels is an important driving factor for the activity of sirtuins to deacetylate target proteins and maintain energy homeostasis. Boron is known to interact with NAD+; therefore, it may affect the activity of sirtuins and the acetylation status of proteins, including the metabolic enzymes involved in oxidative phosphorylation. Targeting sirtuins with boron to modify their deacetylatase activity, it aims to shift the metabolism of cancer cells from glycolysis to oxidative phosphorylation to enhance the efficiency of drugs used in cancer therapy.

Interaction between sodium borate and NAD+ may effect Sirtuins, NAD+dependent deacetylases.

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