Publications

53. Yuk CM, Hong S, Kim D, Kim M, Jeong HW, Park SJ, Min H, Kim W, Lim J, Kim HD, Kim SG, Seong RH*, Kim S* and Lee S-H*. (* co-corresponding author)

Inositol polyphosphate multikinase regulate Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling .Cell Reports, 2025, Feb;44(2):115281. 

52. Lee YE, Lee S-H* and Kim WU*. (* co-corresponding author)

Cytokines, vascular endothelial growth factors, and PlGF in autoimmunity: insights from rheumatoid arthritis to multiple sclerosis Immune Network, 2024, Feb;24(1):e10. 

51. Lee B, Lee S-H* and Shin K*. (* co-corresponding author)

Crosstalk between fibroblasts and T cells in immune networks. Front Immunol, 2023, Jan 9;13:1103823. 

50. Kim YH, Lim JO, Kim JS, Kim BY, Pyun BJ, Lee SJ, Kim DE, Lee S-H, Shin IS and Kim T. 

Protease allergen-induced HMGB1 contributes to NLRC4 inflammasome-mediated inflammation in experimental asthma. Allergy, 2023, Feb 7.

49. Kim D, Kim M, Kim TW, Choe YH, Noh HS, Jeon HM, Kim H, Lee Y, Hur G, Lee KM, Shin K, Lee SI and Lee S-H. 

Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25. J Exp Med, 2022, May 2;219(5):e20200795. 

48. Jeong D, Kim HS, Kim HY, Kang MJ, Jung H, Oh Y, Kim D, Koh J, Cho SY, Jeon YK, Lee EB, Lee S-H, Shin EC, Kim HM, Yi EC and Chung DH. 

Soluble Fas Ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. eLife, 2021, July, 2021;10:e48840. 

47. Kim YJ, Jung E, Shin E, Hong SH, Jeong HS, Hur G, Jeong HY, Lee S-H, Lee JE, Kim GH and Kim J. 

Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation. PNAS, 2020, Aug, 117(33):19994-20003. 

46. Yoo SA, Kim M, Kang MC, Kong JS, Kim KM, Lee S, Hong BK, Jeong GH, Lee J, Shin MG, Kim YG, Apicella I, Cicatiello V, De Falco S, Yoon CH, Cho CS, Ryoo ZY*, Lee S-H* and Kim WU*. (* co-corresponding author)

Placental growth factor regulates the generation of Th17 cells to link angiogenesis with autoimmunity. Nat Immunol, 2019, Oct, 20(10):1348-1359.

45. Ha EH, Choi JP, Kwon HS, Park HJ, Lah SJ, Moon KA, Lee S-H, Kim I and Cho YS. 

Endothelial Sox17 promotes allergic airway inflammation. J Allergy Clin Immunol, 2019, Aug, 144(2):561-173.e6. 

44. Park I, Kim M, Choe K, Song E, Seo H, Hwang Y, Ahn J, Lee S-H, Lee JH, Jo YH, Kim K, Koh GY and Kim P. 

Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury. Eur Respir J, 2019, Jan. 11, pii: 1800786.

43. Kim YH and Lee S-H. 

TGF-b/SMAD4 mediated UCP2 downregulation contributes to Aspergillus protease-induced inflammation in primary bronchial epithelial cells. Redox Biol, 2018, 18:104-113

42. Kim YH, Kim DE and Lee S-H. 

Effects of 18-glycyrrhetinic acid on fungal protease-induced airway inflammatory responses.Mediators Inflamm, 2018, 2018:6461032.

41. Lee HW, Choi B, Kang HN, Kim H, Min A, Cha M, Ryu JY, Park S, Sohn J, Shin K, Yun MR, Han JY, Shon MJ, Jeong C, Chung J, Lee S-H, Im SA, Cho BC and Yoon TY. 

Profiling of protein-protein interactions via single molecule techniques predicts the dependence of cancers on growth factor receptors. Nat Biomed Eng, 2018, 2:239-253.

40. Park HJ, Yuk CM, Shin K, Lee S-H. 

Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation. Mucosal Immunol, 2017, 2017.76.

39. Vadevoo SMP, Kim JE, Gunassekaran GR, Jung HK, Chi L, Kim DE, Lee S-H, Im SH, Lee B. 

Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity. Mol Cancer Ther, 2017,MCT-17-0339.

38. Kim DE, Jang MJ, Kim YR, Lee JY, Cho EB, Kim E, Kim Y, Kim MY, Jeong WI*, Kim S, Han YM and Lee S-H. 

Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.Toxicology, 2017, 387:1-9.

37. Kim DE, Lee Y, Kim M, Lee S, Jon S and Lee S-H. 

Bilirubin nanoparticles ameliorate allergic lung inflammation in a mouse model of asthma.Biomaterials, 2017, 140:37-44

36. Kim E, Beon J, Lee S, Park SJ, Ahn H, Kim MG, Park JE, Kim W, Yuk JM, Kang SJ, Lee S-H, Jo EK, Seong RH, and Kim S. 

Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.Sci Adv, 2017, 3(4):e1602296.

35. Yuk CM, Park HJ, Kwon BI, Lah SJ, Chang J, Kim JY, Lee KM, Park SH, Hong SH and Lee S-H. 

Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity.Sci Rep, 2017, 7:41744.

34. Kim YH and Lee S-H. 

Mitochondrial reactive oxygen species regulate fungal protease-induced inflammatory responses.Toxicology, 2017, 378:86-94.

33. Ahn S, Jeong D, Oh SJ, Ahn J, Lee S-H and Chung DH. 

GM-CSF and IL-4 produced by NKT cells inversely regulate IL-1β production by macrophages.Immunol Lett, 2017, 182:50-56.

32. Kim JH, Choi GE, Lee BJ, Kwon SW, Lee S-H, Kim HS, Jang YJ. 

Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis..Sci Rep, 2016, 6:27615.

31. Kwon BI, Kim TW, Shin K, Kim YH, Yuk CM, Yuk JM, Shin DM, Jo EK, Lee CH and Lee S-H.Enhanced Th2 cell differentiation and function in the absence of Nox2.Allergy, 2017, 72(2):252-265.

30. Lee SH, Shin K, Park S, Kang SM, Choi D, Lee S-H* and Lee SH*. (* co-corresponding author)

Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.Yonsei Med J, 2015, 56(6):1545-1551

29. Shin K, Kataru RP, Park HJ, Kwon BI, Kim TW, Hong YK and Lee S-H.

Th2 cells and their cytokines regulate formation and function of lymphatic vessels.Nature Communications, 2015, 6:6196.

28. Hwang I, Yang J, Hong S, Lee EJ, Lee S-H, Fernandes-Alnemri T, Alnemri ES and Yu J-W.

Nontranscriptional regulation of NLRP3 inflammasome signaling by IL-4.Immunology & Cell Biology, 2015, 93(6):591-599.

27. Shin K and Lee S-H.

Interplay between inflammatory responses and lymphatic vessels.Immune Network, 2014, 14(4):182-186.

26. Shin K, Hwang JJ, Kwon BI, Kheradmand F, Corry DB and Lee S-H.

Leukotriene enhanced allergic lung inflammation through induction of chemokine production.Clin Exp Med, Epub ahead of print, 2015, 15(3):233-44. 

25. Shin K, Hong S, Choi EH, Lim MK, Shim SC, Ju JH and Lee S-H.

Role of citrullinated fibrinogen peptides in activation of CD4 T cells of patients with rheumatoid arthritis.Immune Network, 2013, 13(4):116-122.

24. Jeon JO, Kim S, Choi E, Shin K, Cha K, So IS, Kim SJ, Jun E, Kim D, Ahn HJ, Lee BH, Lee S-H*, and Kim IS*. (* co-corresponding author)

Designed nanocage displaying ligand-specific peptide bunches for high affinity and biological activity.ACS NANO, 2013, 7(9):7462-7471.

23. Kwon BI, Hong S, Shin K, Choi EH, Hwang JJ and Lee S-H.

Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax.Am J Resp Crit Care Med, 2013, 188(5):577-585

22. Knight JM, Lee S-H, Roberts L, Smith CW, Weiss ST, Kheradmand F and Corry DB.

CD11a polymorphisms regulate Th2 cell homing and Th2-related disease.The Journal of Allergy and Clinical Immunology, 2014, 133(1):189-197 

21. Nam SJ, Oh IS, Yoon YH, Kwon BI, Kang W, Kim HJ, Nahm SH, Choi YH, Lee S-H, Racanelli V and Shin EC.

Apocynin regulates cytokine production of CD8+ T cells.Clin Exp Med, Epub ahead of print, 2014, 14(3):261-268 

20. Shin K, Chung H, Kim DU, Hwang JK, Lee S-H.

Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma.Life Sciences, 2013, 92:1093-1099. 

19. Lee H, Bae S, Jang J, Choi BW, Park CS, Park JS, Lee S-H, Yoon Y.

CD53, a suppressor of inflammatory cytokine production, is associated with population asthma risk via the functional promoter polymorphism-1560 C>T.Biochim Biophys Acta (BBA-General Subjects), 2013, 1830:3011-3018. 

18. Lee S-H.

Mechanism of allergic asthma pathogenesis by protease allergen.Hanyang Medical Reviews, 2013, 33:39-44.

17. Hong YJ, Kim J, Oh BR, Lee YJ, Lee EY, Lee EB, Lee S-H, Song YW.

Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis.Journal of Korean Medical Science, 2012, 27(5):484-488.

16. Hwang JJ, Min SH, Sin KH, Heo YS, Kim KD, Yoo OJ, Lee S-H.

Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer.Oncology Reports, 2012, 27:535-540.

15. Hong JS, Greenlee KJ, Pitchumani R, Song LZ, Shan M, Chang SH, Park PW, Dong C, Werb Z, Bidani A, Corry DB, Kheradmand F.

Dual protective mechanisms of matrix metalloproteinase 2 and 9 in immune defense against Streptococcus pneumoniae.Journal of Immunology, 2011, 186(11):6427-6436.

14. Kim DY, Kwon EY, Hong GU, Lee YS, Lee S-H, Ro JY.

Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells.Respiratory Research, 2011, 12(1):49. 

13. Kataru RP, Kim H, Jang C, Choi DK, Koh BI, Kim M, Gollamudi S, Kim YK, Lee S-H*, and Koh GY*. (* co-corresponding author)

T lymphocytes negatively regulate lymph node lymphatic vessel formation.Immunity, 2011, 34(1):96-107.

12. Hong SC and Lee S-H.

Role of Th17 cell and autoimmunity in chronic obstructive pulmonary disease. Immune Network, 2010, 10(4):109-114. 

11. Singh M*, Lee S-H*, Porter P, Xu C, Ohno A, Atmar RL, Greenberg SB, Bandi V, Gern J, Amineva S, Aminev A, Skern T, Smithwick P, Perusich S, Barrow N, Roberts L, Corry DB, and Kheradmand F. 

Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. The Journal of Allergy and Clinical Immunology, 2010, 25(6):1369-1378 

10. Shan M, Cheng H-F, Song L-Z, Roberts L, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Storness-Bliss C, Ramchandani M, Lee S-H, Corry DB and Kheradmand F.

Lung Myeloid Dendritic Cells Coordinately Induce TH1 and TH17 Responses in Human Emphysema. Science Translational Medicine, 2009, 1(4):4ra 10. 

9. Lee, S-H., Prince, J.E., Rais, M., Kheradmand, F., Ballantyne, C.M., Weitz-Schmidt,G., Smith, C.W. and Corry, D.B.  

 Developmental control of integrin expression regulates Th2 effector homing. Journal of Immunology, 2008, 180 (7): 4656 - 4667.

8. Lee, S-H., Goswami, S., Grudo, A., Song, L-Z., Bandi, V., Goodnigh-White, S., Green, L., Hacken, J., Huh, J., Bakaeen, F., Coxson, H., Cogswell, S., Storness-Bliss, C., Corry, DB., & Kheradmand, F. 

Anti-Elastin Autoimmunity in Tobacco Smoking-Induced Emphysema. Nature Medicine, 2007, 13 (5): 567 - 569.

7. Lee, S-H. and Corry, D.B. 

Homing alone? CD18 in infectious and allergic disease.Trends in Molecular Medicine, 2004, 10 (6): 258 - 262.

6. Corry, D.B., Kiss, A., Song, LZ., Song, L., Xu, J., Lee, S-H., Werb, Z. and Kheradmand, F. 

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J. 2004, 18 (9): 995 - 997.

5. Lee, S-H*., Kiss, A.*, Xu, J., Qian, Y., Bashoura, L., Kheradmand, F. and Corry, D.B. 

Airway glycoprotein secretion parallels production and predicts airway obstruction in pulmonary allergy. The Journal of Allergy and Clinical Immunology, 2004, 113 (1): 72 - 78.

4. Lee, S-H.*, Prince, J.E.*, Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., Beaudet, A.L., Smith, C.W., Soong, L. and Corry, D.B.    

Differential requirement for CD18 in T-helper effector homing. Nature Medicine, 2003, 9 (10): 1281 - 1286.

3. Kheradmand, F., Kiss, A., Xu, J., Lee, S-H., Kolattukudy, P.E. and Corry, D.B.

A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. Journal of Immunology, 2002, 169 (10): 5904 - 5911.

2. Hubbard, N.E., Lee, S-H., Lim, D and Erickson, K.L.

Differential mRNA expression of prostaglandin receptor subtypes in macrophage activation. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2001, 65 (5-6): 287 - 294.

1. Seung-Hyo Lee, Kyung-Min Cho, Jung-Hee Lim, Yong-Sup Song, Hyoung-Sik Chun, Hyeog-Jin Son and Sang-Kyou Lee.

A Novel Cell line for Screening of Immunosuppressor Specific to T Lymphocytes. The Korean Journal of Immunology, 1997, 19 (3): 375 - 381.

6. Mi Young Kim, Seung-Hyo Lee, Yong-Mahn Han, Won-Il Jeong, Beomjin Hong. 

High-throughput screening method for hepatotoxicity using hepatocytes derived from human embryonic stem cells.

The application number: 10-2017-0035210 (filed on 2017-03-21)

5. Seung-Hyo Lee, Seyun Kim, Yong-Mahn Han. 

Immunotoxicity verification techniques using human stem cell-derived hepatocytes

The application number: 10-2015-0047678 (filed on 2015-04-03)

Certificate number: 10-1856603 (filed on 2018-05-03)

4. Seyun Kim, Yong-Mahn Han, Seung-Hyo Lee. 

Hepatotoxic drug screening method by analysis of secreting metabolites 

The application number: 10-2015-0018632 (filed on 2015-02-06)

Certificate number: 10-1856599 (filed on 2018-05-03)

3. Seung-Hyo Lee, Seyun Kim, Yong-Mahn Han. 

Method for hepatotoxicity screening of immune based hepato-toxicity using human stem cell derived hepatocytes 

The application number: 10-2014-0024898 (filed on 2014-03-03)

The PCT application number: PCT/KR2015/002038 (filed on 2015-03-03)

2. Seung-Hyo Lee, Eunsu Choi, and Dongeon Kim. 

Composition for preventing or treating asthma comprising mutant protease allergen 

The application number: 10-2012-0076149 (filed on 2012-07-12)

Certificate number: 10-1492236 (filed on 2015-02-04)

1. Seung-Hyo Lee, Seok Chan Hong, and Kihyuk Shin. 

Methods for production of chronic obstructive pulmonary disease for autoimmune disease animal model 

The application number: 10-2012-0076150 (filed on 2012-07-12) 

Certificate number: 10-1390463 (filed on 2014-04-23)