The Church of the Rosary (in italian Chiesa del Rosario) assumed its current name during the 1600s, after a Dominican convent was built next to it: since then it began to be called "Saint Dominic Church” or "Church of the Rosary” (because of Saint Dominic’s devotion to the Rosary).

Originally, the church was instead dedicated to the Annunciation, at the behest of Baron Enrico Rosso, lord of Militello, at the end of the 15th century. He built it to house the remains of his wife Laura, who died prematurely in 1484.

Its original identity however still emerges today in a typical saying used by people of Militello, who commonly say “arreri a 'Nnunziata” to indicate those places beyond the square and behind the church

The single chamber church has a deep presbytery. The ceiling is coffered in wood. The church portal is made of limestone richly decorated with esoteric figures and symbols.

The building, restored in the seventies at the behest of Sister Angela Montalbano, houses many of the most important works of art that the Renaissance expressed in the Nebrodi area.

Noteworthy are the three Carrara marble masterpieces. Firstly, the monumental sarcophagus of Laura Rosso de 'Playa (Palermo family of Catalan origin). The figure of the lying noblewoman constitutes the tombstone of the sepulchre and is characterized by the richness of the wisely reproduced period costumes. At the back of the church on the right, a splendid arch can be admired (called the Arch of the Annunciation, due to the scenes reproduced on its vault) which frames the altar on which the statue of Madonna with the Child is placed.

On all three marble works appear the coats of arms of the Rosso barons (a shield with an eight-pointed star) and of the Playa family (a shield with three stripes and three circles).

The Church also preserves the valuable triptych of Saint Dominic, a large wooden composition of 1683 covered in pure gold that contains a painting on canvas depicting Saint Dominic in Soriano.

Also worthy of mention is the superb statue of Saint Vincent Ferrer, attributed to Filippo Quattrocchi (18th century). Noteworthy are both the precious tabernacle with the overhanging wooden choir loft painted with musical angels and singers (the decoration dates back to the 18th century), and the background frescoes of the presbytery (on the left Saint Vincent Ferrer and on the right Pope Pius V).

The church also houses the burial of Antonio Giambruno (just to the right of the entrance) as well as valuable paintings and statues from the suppressed monasteries (Franciscan and Benedictine) and from the destroyed churches. Relevant is a large oil painting depicting the Madonna of the Letter (copy of a canvas preserved in the Palazzo Senatorio in Messina, definitively destroyed by the 1908 earthquake).

In 1912, a large clock was placed on the side of the church, operating by means of a mechanism of springs and counterweights. In correspondence with the clock, a loggia was erected to house the two bells that would strike the hours and quarters.