PUBLICATIONS

Mbah, NE., Myers, AL., Sajjakulnukit, P., Chung, C., Thompson, JK., Hong, HS., Giza, H., Dang, D., Nwosu, ZC., Shan, M., Sweha, SR., Maydan, DD., Chen, B., Zhang, L., Magnuson, B., ...  Venneti, S., Lyssiotis, CA., (2024). Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma. Nature Communications, 15:8983, https://doi.org/10.1038/s41467-024-52973-4

Koschmann, C., Al-Holou, WN., Alonso MM., Anastas, J., Bandopadhayay, P., Barron, T., Becher, O., Cartaxo, R., Castro, MG., Chung, C., Clausen, M., Dang, D.,  Doherty, R., Duchatel, R., Dun, M., Filbin, M., … Venneti, S.,  (2024). A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell, 42 (1), https://doi.org/10.1016/j.ccell.2023.11.002

2023

Venneti, S., Kawakibi, A. R., Ji, S., Waszak, S. M., Sweha, S. R., Mota, M., Pun, M., Deogharkar, A., Chung, C., Tarapore, R. S., Ramage, S., Chi, A., Wen, P. Y., Arrillaga-Romany, I., Batchelor, T. T., Butowski, N. A., Sumrall, A., Shonka, N., Harrison, R. A., de Groot, J., … Koschmann, C. (2023). Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways. Cancer discovery, 13 (11), https://doi.org/10.1158/2159-8290.CD-23-0131 

Mota, M., Sweha, SR., Pun, M., Natarajan, SK., Ding, Y., Chung, C., Hawes, D., Yang, F., Judkins, AR., Samajdar, S., Cao, X., Xiao, L., Parolia, A., Chinnaiyan, AM., Venneti, S., Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas, (2023) Proc Natl Acad Sci U S A, 120 (18), https://doi.org/10.1073/pnas.2221175120

Park, J., Chung, C., Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma, (2023) Brain Tumor Research and Treatment, 11 (2), https://doi.org/10.14791/btrt.2023.0011

Chung, C., Cho, H.J., Lee, C.E.,  Koo, J.H., Odorant receptors in cancer, (2022) BMB reports, 55 (2), https://doi.org/10.5483/BMBRep.2022.55.2.010

Sweha, S.R., Chung, C., Natarajan, S.K., Panwalkar, P., Pun, M., Ghali, A., Bayliss, J., Pratt, D., Shankar, A., Ravikumar, V., Rao, A., Cieslik, M., Wilder-Romans, K., Scott, A.J., Wahl, D.R., Jessa, S., Kleinman, C.L., Jabado, N., MacKay, A., Jones, C., Martinez, D., Santi, M., Judkins, A.R., Yadav, V.N., Qin, T., Phoenix, T.N., Koschmann, C.J., Baker, S.J., Chinnaiyan, A.M., Venneti, S., Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas, (2021) Science Translational Medicine, 13 (615), https://doi.org/10.1126/scitranslmed.abf7860

Panwalkar, P., Tamrazi, B., Dang, D., Chung, C., Sweha, S., Natarajan, S.K., Pun, M., Bayliss, J., Ogrodzinski, M.P., Pratt, D., Mullan, B., Hawes, D., Yang, F., Lu, C., Sabari, B.R., Achreja, A., Heon, J., Animasahun, O., Cieslik, M., Dunham, C., Yip, S., Hukin, J., Phillips, J.J., Bornhorst, M., Griesinger, A.M., Donson, A.M., Foreman, N.K., Garton, H.J.L., Heth, J., Muraszko, K., Nazarian, J., Koschmann, C., Jiang, L., Filbin, M.G., Nagrath, D., Kool, M., Korshunov, A., Pfister, S.M., Gilbertson, R.J., David Allis, C., Chinnaiyan, A.M., Lunt, S.Y., Blüml, S., Judkins, A.R., Venneti, S. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas, (2021) Science Translational Medicine, 13 (614), https://doi.org/10.1126/scitranslmed.abc0497

Liu, E.A., Schultz, M.L., Mochida, C., Chung, C., Paulson, H.L., Lieberman, A.P., Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain, (2020) JCI Insight, 5 (20), https://doi.org/10.1172/jci.insight.136676

Chung, C., Sweha, S.R., Pratt, D., Tamrazi, B., Panwalkar, P., Banda, A., Bayliss, J., Hawes, D., Yang, F., Lee, H.-J., Shan, M., Cieslik, M., Qin, T., Werner, C.K., Wahl, D.R., Lyssiotis, C.A., Bian, Z., Shotwell, J.B., Yadav, V.N., Koschmann, C., Chinnaiyan, A.M., Blüml, S., Judkins, A.R., Venneti, S. Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas, (2020) Cancer Cell, 38 (3), https://doi.org/10.1016/j.ccell.2020.07.008

Panwalkar, P., Pratt, D., Chung, C., Dang, D., Le, P., Martinez, D., Bayliss, J.M., Smith, K.S., Adam, M., Potter, S., Northcott, P.A., Mascarenhas, L., Shows, J., Pawel, B., Margol, A., Huang, A., Judkins, A.R., Venneti, S., SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors, (2020) Neuro-Oncology, 22 (6), https://doi.org/10.1093/neuonc/noaa004

Panwalkar, P., Clark, J., Ramaswamy, V., Hawes, D., Yang, F., Dunham, C., Yip, S., Hukin, J., Sun, Y., Schipper, M.J., Chavez, L., Margol, A., Pekmezci, M., Chung, C., Banda, A., Bayliss, J.M., Curry, S.J., Santi, M., Rodriguez, F.J., Snuderl, M., Karajannis, M.A., Saratsis, A.M., Horbinski, C.M., Carret, A.-S., Wilson, B., Johnston, D., Lafay-Cousin, L., Zelcer, S., Eisenstat, D., Silva, M., Scheinemann, K., Jabado, N., McNeely, P.D., Kool, M., Pfister, S.M., Taylor, M.D., Hawkins, C., Korshunov, A., Judkins, A.R., Venneti, S., Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome, (2017) Acta Neuropathologica, 134 (5), https://doi.org/10.1007/s00401-017-1752-4

Bayliss, J., Mukherjee, P., Lu, C., Jain, S.U., Chung, C., Martinez, D., Sabari, B., Margol, A.S., Panwalkar, P., Parolia, A., Pekmezci, M., McEachin, R.C., Cieslik, M., Tamrazi, B., Garcia, B.A., La Rocca, G., Santi, M., Lewis, P.W., Hawkins, C., Melnick, A., Allis, C.D., Thompson, C.B., Chinnaiyan, A.M., Judkins, A.R., Venneti, S., Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas, (2016) Science Translational Medicine, 8 (366), https://doi.org/10.1126/scitranslmed.aah6904

Chung, C., Elrick, M.J., Dell’Orco, J.M., Qin, Z.S., Kalyana-Sundaram, S., Chinnaiyan, A.M., Shakkottai, V.G., Lieberman, A.P., Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease, (2016) PLoS Genetics, 12 (5), https://doi.org/10.1371/journal.pgen.1006042

Chung, C., Puthanveetil, P., Ory, D.S., Lieberman, A.P., Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration, (2016) Human Molecular Genetics, 25 (7), https://doi.org/10.1093/hmg/ddw025

Praggastis, M., Tortelli, B., Zhang, J., Fujiwara, H., Sidhu, R., Chacko, A., Chen, Z., Chung, C., Lieberman, A.P., Sikora, J., Davidson, C., Walkley, S.U., Pipalia, N.H., Maxfield, F.R., Schaffer, J.E., Ory, D.S., A murine Niemann-Pick C1 I1061T knock-In model recapitulates the pathological features of the most prevalent human disease allele, (2015) Journal of Neuroscience, 35 (21), https://doi.org/10.1523/JNEUROSCI.4173-14.2015

Elrick, M.J., Yu, T., Chung, C., Lieberman, A.P., Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease, (2012) Human Molecular Genetics, 21 (22), https://doi.org/10.1093/hmg/dds324

Yu, T., Chung, C., Shen, D., Xu, H., Lieberman, A.P. Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts, (2012) Human Molecular Genetics, 21 (14), https://doi.org/10.1093/hmg/dds145

Yu, T., Shakkottai, V.G., Chung, C., Lieberman, A.P., Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration, (2011) Human Molecular Genetics, 20 (22), https://doi.org/10.1093/hmg/ddr372

Park, S.G., Min, J.Y., Chung, C., Hsieh, A., Jung, G., Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx, (2009) Cancer Letters, 282 (2), https://doi.org/10.1016/j.canlet.2009.03.019

Roberts, B.E., Duennwald, M.L., Wang, H., Chung, C., Lopreiato, N.P., Sweeny, E.A., Knight, M.N., Shorter, J., A synergistic small-molecule combination directly eradicates diverse prion strain structures, (2009) Nature Chemical Biology, 5 (12), https://doi.org/10.1038/nchembio.246 

Chung, C., Park, S.G., Park, Y.M., Joh, J.-W., Jung, G., Interferon-γ sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-κB activation, (2007) Cancer Science, 98 (11), https://doi.org/10.1111/j.1349-7006.2007.00591.x

Sung, G.P., Chung, C., Kang, H., Kim, J.-Y., Jung, G., Up-regulation of cyclin D1 by HBx is mediated by NF-κB2/BCL3 complex through κB site of cyclin D1 promoter,(2006) Journal of Biological Chemistry, 281 (42), https://doi.org/10.1074/jbc.M603194200