Publications

Lung patterning: Is a distal-to-proximal gradient of cell allocation and fate decision a general paradigm? Zhang K, Aung T, Yao E, Chuang PT. Bioessays 2023 Nov 27:e2300083. doi: 10.1002/bies.202300083. PMID: 38010492.

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.  Zhang, K., Yao, E., Chuang, E. et al. Nat Commun 13, 7252 (2022). PMID: 36433959; PMCID: PMC9700781.

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT. PLoS Biol. 2022 Aug 26;20(8):e3001759. PMID: 36026468; PMCID: PMC9469998.

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange. Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT. Dev Cell. 2022 Jul 11;57(13):1566-1581.e7. PMID: 35714603; PMCID: PMC9308505.

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. Elife. 2022 Apr 6;11:e68598. PMID: 35384838; PMCID: PMC9183236.

A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT. Elife. 2020 May 12;9:e53688. PMID: 32394892; PMCID: PMC7217702; Faculty Opinions. 

Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury. Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT. Stem Cells. 2018 Mar;36(3):377-391. PMID: 29148109.

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT. 2017. Elife. 2017 Mar 21;6. pii: e21130. PMID: 28323616; PMCID: PMC5360446.

Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma. Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT. 2017. J Biol Chem 292(9):3888-3899. PMID: 28119454; PMCID: PMC5339769.

A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Lin C, Yao E, Chuang PT. 2015. Dev Biol 403(1):101-13. PMID: 25912685; PMCID: PMC4469623.

Hedgehog signaling: From basic research to clinical applications. Yao E, Chuang PT. 2015. J Formos Med Assoc 114(7):569-76. PMID: 25701396.

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT. 2014. Genes Dev 28(22):2547-63. PMID: 25403183; PMCID: PMC4233246.

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Lin C, Chen M-H, Yao E, Song H, Gacayan R, Hui CC, Chuang, PT. 2014. Dev Biol 392(2):324-33. PMID: 24886827; PMCID: PMC4106470.

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC. 2014. Dev Cell 29(2):241-9. PMID: 24726283.

Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis. Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang PT. 2014. Dev Biol 388(2):170-80. PMID: 24525297; PMCID: PMC3982599.

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Nozawa YI, Lin C, Chuang PT. 2013. Curr Opin Genet Dev 23(4):429-37. PMID: 23725801; PMCID: PMC3913210.

Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT. 2013. Dev Dyn 242(11):1307-19. PMID: 23907739.

The path to chemotaxis and transcription is smoothened. Lin C, Nozawa YI, Chuang, PT. 2012. Sci Signal 5(238):pe35. PMID: 22912492.

Alveolar Type II Cells Possess the Capability of Initiating Lung Tumor Development. Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang, PT. 2012. PLoS ONE 7(12): e53817. Epub 2012 Dec 20. PMID: 23285300; PMCID: PMC3527621.

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT. 2012 Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17531-6. PMID: 23047698; PMCID: PMC3491514; Faculty Opinions. 

A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow. Engel B.D., Ishikawa H., Feldman J.L., Wilson C.W., Chuang P.-T., Snedecor J., Williams J., Sun Z., Marshall W.F. 2011. Cytoskeleton 68(3):188-203. PMID: 21360831.

Mechanism and evolution of cytosolic Hedgehog signal transduction. Wilson C.W., Chuang P.-T. 2010. Development, 137(13): 2079-2094. PMID: 20530542; PMCID: PMC2882129.

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Chen M.-H., Wilson C.W., Li Y.-J., Law K.K., Lu C.-S., Gacayan R., Zhang X., Hui C.-c., Chuang P.-T. 2009. Genes Dev 23(16):1910-28. PMID: 19684112; PMCID: PMC2725943;  Faculty Opinions. 

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. Wilson C.W., Chen M.-H., Chuang P.-T. 2009. PLoS ONE 4(4):e5182. Epub 2009 April 13. PMID: 19365551; PMCID: PMC2664476.

Fused has evolved divergent roles in vertebrate Hedgehog signaling and motile ciliogenesis. Wilson C.W., Nguyen C., Chen M.-H., Yang J.-H., Gacayan R., Chen J.-N., Chuang P.-T. 2009. Nature 459 (7243):98-102. Epub 2009 Mar 22. PMID: 19305393; PMCID: PMC3204898; Faculty Opinions. 

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Mak K.K., Bi Y., Wan C., Chuang P.-T., Clemens T., Young M., Yang Y. 2008. Dev Cell 14(5):674-88. PMID: 18477451.

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Mak K.K., Kronenberg H.M., Chuang P.-T., Mackem S., Yang Y. 2008.  Development 135(11):1947-56. PMID: 18434416; PMCID: PMC7188307.

Kif3a constrains beta-catenin-dependent Wnt signaling through dual ciliary and non-ciliary mechanisms. Corbit K.C., Shyer A.E., Dowdle W.E., Gaulden J., Singla V., Chen M.-H., Chuang P.-T., Reiter J.F. 2008.  Nat Cell Biol 10(1):70-6 [Erratum in Nat Cell Biol. 2008 Apr;10(4):497]. PMID: 18084282.

SnapShot: hedgehog signaling pathway. Chen M.-H., Wilson C.W., Chuang P.-T. 2007.  Cell 130(2):386. PMID: 17662951.

The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Gerber A.N., Wilson C.W, Li Y.-J., Chuang P.-T. 2007.  Oncogene 26:1122-1136. PMID: 16964293; PMCID: PMC3325095.

Wnt/ß-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Mak K.K., Chen M.-H., Day T.F., Chuang P.-T., Yang Y. 2006.  Development 133(18):3695-707. PMID: 16936073.

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Ochi H., Pearson B.J., Chuang P.-T., Hammerschmidt M, Westerfield M. 2006. Dev Biol 297(1):127-40. PMID: 16765934.

New "Hogs" in Hedgehog transport and signal reception. Wilson C.W., Chuang P.-T. 2006. Cell 125(3):435-8. PMID: 16678090.

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Hu M.C., Mo R., Bhella S., Wilson, C., Chuang P.-T., Hui C.C., Rosenblum N.D. 2006. Development 133(3):569-78. PMID: 16396903.

Mice deficient in the Fused homolog do not exhibit phenotypes indicative of perturbed Hedgehog signaling during embryonic development. Chen M.-H., Gao N., Kawakami T., Chuang P.-T. 2005. Mol Cell Biol 25(16):7042-53. PMID: 16055716; PMCID: PMC1190231.

N-Myristoyltransferase I is essential in early mouse development. Yang S.H., Shrivastav A., Kosinski C., Sharma R.K., Chen M.-H., Berthiaume L.G.,Peters L.L., Chuang P.-T., Young S.G., Bergo M.O. 2005.  J Biol Chem. 180(19):18990-5. PMID: 15753093.

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Chen M.-H., Li Y.-J., Kawakami T., Xu S.-M., Chuang P.-T. 2004. Genes Dev 18(6):641-59. PMID: 15075292; PMCID: PMC387240; Faculty Opinions. 

Immunoprevention of basal cell carcinoma with recombinant Hedgehog-interacting protein. Vogt A., Chuang P.-T., Hebert J., Hwang J., Lu Y., Kopelovich L., Athar M., Bickers D.R., Epstein E.H. Jr. 2004.  J Exp Med 199(6):753-61. PMID: 15024045; PMCID: PMC2212732.

Combined activities of hedgehog signaling inhibitors regulate pancreas development. Kawahira H., Ma N.H., Tzanakakis E.S., McMahon A.P., Chuang P.-T., Hebrok M. 2003.  Development 130(20):4871-9. PMID: 12917290.

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding Protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Chuang P.-T.*, Kawcak T., McMahon A.P. 2003.  Genes Dev 17(3):342-7.  (*co-corresponding author) PMID: 12569124; PMCID: PMC195990.

Branching morphogenesis of the lung: new molecular insights into an old problem. Chuang P.-T.; McMahon A.P. 2003. Trends Cell Biol 13(2):86-91. PMID: 12559759.

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D., Kawamoto M., Huang C.C., Johns S.J., King L.A., Harper C.A., Meng E.C., Lee R.E., Yee A., L'Italien L., Chuang P.-T., Young S.G., Skarnes W.C., Babbitt P.C., Ferrin T.E. 2003. Nucleic Acids Res 31(1):278-81. PMID: 12520002; PMCID: PMC165511.

Mouse dispatched mutants fail to distribute Hedgehog proteins and are defective in Hedgehog signaling. Kawakami T., Kawcak T., Li Y.-J., Zhang W., Hu Y., Chuang P.-T. 2002. Development 129(24):5753-65. PMID: 12421714.

Activation of expression of hedgehog target genes in basal cell carcinomas. Bonifas J.M., Pennypacker S., Chuang P.-T., McMahon A.P., Williams M., Rosenthal A., De Sauvage F.J., Epstein E.H. Jr. 2001.  J Invest Dermatol 116(5):739-42. PMID: 11348463.

Hedgehog signaling is required for pituitary gland development. Treier M., O'Connell S., Gleiberman A., Price J., Szeto D.P., Burgess R., Chuang P.-T., McMahon A.P., Rosenfeld M.G. 2001. Development 128(3):377-86. PMID: 11152636.

 Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting protein gene and analysis of its role in holoprosencephaly. Huo L., Roessler E., Dutra A., Chuang P.-T., McMahon A.P., Muenke M. 2000. Gene Funct. Dis 3-4:119-127.

On the range of Hedgehog signaling. Chuang P.-T.; Kornberg T.B. 2000. Curr Opin Genet Dev 10(5):515-22. PMID: 10980429.

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Chuang P.-T., McMahon A.P. 1999. Nature 397(6720):617-21. PMID: 10050855.

MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. Lieb J.D., Albrecht M.R., Chuang P.-T., Meyer B.J. 1998. Cell 92(2):265-77. PMID: 9458050.

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Yang Y., Drossopoulou G., Chuang P.-T., Duprez D., Marti E., Bumcrot D., Vargesson N., Clarke J., Niswander L., McMahon A., Tickle C. 1997. Development 124(21):4393-404. PMID: 9334287.

Sex-specific assembly of a dosage compensation complex on the nematode X chromosome. Chuang P.-T., Lieb J.D., Meyer B.J. 1996.  Science 274(5293):1736-9. PMID: 8939870.

Hedgehogs in the clinic. McMahon A.P.; Chuang P.-T. 1996. Nat Med 2(12):1308-10. PMID: 8946825.

DPY-30, a novel nuclear protein essential early in embryogenesis for C. elegans dosage compensation. Hsu D.R., Chuang P.-T., Meyer B.J. 1995. Development 121(10):3323-34. PMID: 7588066.

DPY-27: A Chromosome condensation protein homolog that regulate C. elegans dosage compensation through association with the X chromosome. Chuang P.-T., Albertson D.G., Meyer B.J. 1994. Cell 79(3):459-74. PMID: 7954812.

 Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Hariharan I.K., Chuang P.-T., Rubin G.M. 1991. Proc. Natl. Acad. Sci. USA 88(24):11266-70. PMID: 1662390; PMCID: PMC53115.

Macromolecular transport across surface arterial and venous endothelium in rats. Studies with Evans blue-albumin and horseradish peroxidase. Chuang P.-T., Cheng H.-J., Lin S.-J., Jan K.-M., Lee M.-M., Chien S. 1990. Arteriosclerosis 10(2):188-97. PMID: 2180395.