Adhesive, also known as glue, cement, mucilage, or paste,[1] is any non-metallic substance applied to one or both surfaces of two separate items that binds them together and resists their separation.[2]

In 2000, a paper revealed the discovery of a 5,200-year-old man nicknamed the "Tyrolean Iceman" or "tzi", who was preserved in a glacier near the Austria-Italy border. Several of his belongings were found with him including two arrows with flint arrowheads and a copper hatchet, each with evidence of organic glue used to connect the stone or metal parts to the wooden shafts. The glue was analyzed as pitch, which requires the heating of tar during its production. The retrieval of this tar requires a transformation of birch bark by means of heat, in a process known as pyrolysis.[11]


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From AD 1 to 500 the Greeks and Romans made great contributions to the development of adhesives. Wood veneering and marquetry were developed, the production of animal and fish glues refined, and other materials utilized. Egg-based pastes were used to bond gold leaves, and incorporated various natural ingredients such as blood, bone, hide, milk, cheese, vegetables, and grains.[9] The Greeks began the use of slaked lime as mortar while the Romans furthered mortar development by mixing lime with volcanic ash and sand. This material, known as pozzolanic cement, was used in the construction of the Roman Colosseum and Pantheon.[12] The Romans were also the first people known to have used tar and beeswax as caulk and sealant between the wooden planks of their boats and ships.[9]

In Central Asia, the rise of the Mongols in approximately AD 1000 can be partially attributed to the good range and power of the bows of Genghis Khan's hordes. These bows were made of a bamboo core, with horn on the belly (facing towards the archer) and sinew on the back, bound together with animal glue.[13]

There are two types of adhesives that harden by drying: solvent-based adhesives and polymer dispersion adhesives, also known as emulsion adhesives. Solvent-based adhesives are a mixture of ingredients (typically polymers) dissolved in a solvent. White glue, contact adhesives and rubber cements are members of the drying adhesive family. As the solvent evaporates, the adhesive hardens. Depending on the chemical composition of the adhesive, they will adhere to different materials to greater or lesser degrees.

Thermoplastic glue may have been invented around 1940 by Procter & Gamble as a solution to the problem that water-based adhesives, commonly used in packaging at that time, failed in humid climates, causing packages to open. However, water-based adhesives are still of strong interest as they typically do not contain volatile solvents.[28]

Natural adhesives are made from organic sources such as vegetable starch (dextrin), natural resins, or animals (e.g. the milk protein casein[35] and hide-based animal glues). These are often referred to as bioadhesives.

One example is a simple paste made by cooking flour in water. Starch-based adhesives are used in corrugated board and paper sack production, paper tube winding, and wallpaper adhesives. Casein glue is mainly used to adhere glass bottle labels. Animal glues have traditionally been used in bookbinding, wood joining, and many other areas but now are largely replaced by synthetic glues except in specialist applications like the production and repair of stringed instruments. Albumen made from the protein component of blood has been used in the plywood industry. Masonite, a wood hardboard, was originally bonded using natural wood lignin, an organic polymer, though most modern particle boards such as MDF use synthetic thermosetting resins.

In some cases, an actual chemical bond occurs between adhesive and substrate. Thiolated polymers (=thiomers), for example, form chemical bonds with endogenous proteins such as mucus glycoproteins, integrins or keratins via disulfide bridges.[38] Because of their comparatively high adhesive properties, these polymers find numerous biomedical applications. In others, electrostatic forces, as in static electricity, hold the substances together. A third mechanism involves the van der Waals forces that develop between molecules. A fourth means involves the moisture-aided diffusion of the glue into the substrate, followed by hardening.

Some glues and adhesives have a limited shelf life. Shelf life is dependent on multiple factors, the foremost of which being temperature. Adhesives may lose their effectiveness at high temperatures, as well as become increasingly stiff.[40] Other factors affecting shelf life include exposure to oxygen or water vapor.

Cas9 is a programmable nuclease that has furnished transformative technologies, including base editors and transcription modulators (e.g., CRISPRi/a), but several applications of these technologies, including therapeutics, mandatorily require precision control of their half-life. For example, such control can help avert any potential immunological and adverse events in clinical trials. Current genome editing technologies to control the half-life of Cas9 are slow, have lower activity, involve fusion of large response elements (> 230 amino acids), utilize expensive controllers with poor pharmacological attributes, and cannot be implemented in vivo on several CRISPR-based technologies. We report a general platform for half-life control using the molecular glue, pomalidomide, that binds to a ubiquitin ligase complex and a response-element bearing CRISPR-based technology, thereby causing the latter's rapid ubiquitination and degradation. Using pomalidomide, we were able to control the half-life of large CRISPR-based technologies (e.g., base editors, CRISPRi) and small anti-CRISPRs that inhibit such technologies, allowing us to build the first examples of on-switch for base editors. The ability to switch on, fine-tune and switch-off CRISPR-based technologies with pomalidomide allowed complete control over their activity, specificity, and genome editing outcome. Importantly, the miniature size of the response element and favorable pharmacological attributes of the drug pomalidomide allowed control of activity of base editor in vivo using AAV as the delivery vehicle. These studies provide methods and reagents to precisely control the dosage and half-life of CRISPR-based technologies, propelling their therapeutic development.

And sometimes, technical data folks report into or have to pitch their promotion recommendations to a less technical leader. In that case, highly technical work can actually become glue work, including:

Glue work puts the health of the team ahead of individual accomplishments. It is core to the success of individual projects, but also to maximizing the impact of the analytics team overall. Explicitly valuing glue work and not relying on volunteers to do it helps team remain sucessful while leveling the playing field and improving gender equity.

The researchers tested the strength of these glues in many scenarios. The new glues adhered strongly to the surfaces of tissues from a pig, including skin, cartilage, heart, and liver. The team found that the adhesion could be as strong as natural cartilage binding to bone. The glues adhered so well because they are stretchy rather than brittle like currently available medical adhesives, such as cyanoacrylate. This flexibility allows them to spread out the forces that normally cause adhesives to fail.

The team compared the performance of their family of glues to commercially available medical adhesives. The new glues adhered much more strongly than commercial adhesives. They also adhered more slowly, so that a surgeon would be able to position a seal precisely over tissues before the glue hardened.

Exposure to the chemicals in glue can lead to an irregular heartbeat (arrhythmia). In some cases, the abnormal rhythms can lead to fatal heart failure. This is known as sudden sniffing death syndrome (SSDS), and it can occur from just one attempt.

My business was in a tough spot, looking for an entirely new way to perform our gluing process on our product that we manufacture. I reached out to Glue Machinery, and they were super helpful not only in going over my process, but getting samples done and simulating my process in their shop. We worked from concept to finished samples within weeks, and I bought the machine knowing that it was going to work 100%! My process is faster and more economical than ever now, and my product glued more professionally and strongly, thanks to Glue Machinery. A great company with great people, producing an excellent adhesive solution."

glue_data() works like glue(), but instead of looking up its variables from the calling environment it looks them up from the first argument (usually a data frame or tibble). This makes glue_data() very useful within pipe chains.

New to glue 1.2.0 are transformer functions, which allow you to define custom behavior for glue functions. For example a collapse_transformer() which automatically collapses any blocks which end with *.

This simple organization tool puts all of your Chrome tabs together into one window with a single click. The new window has your tabs arranged in the same order your windows were, and makes the selected tab in your current window be the new selected tab, so you won't lose track of where your tabs were or what you were doing.It has an option to include minimized windows.It works great with Tab Scissors ( ), which splits your window into two convenient side-by-side windows, so that you can rearrange your tabs in groups.Version 1.2 Update: You can now also perform a glue or cut using a shortcut specified on the chrome extensions page. Default is Alt+S to cut, Alt+G to glue, Alt+A to glue all (including minimized windows)

Cyanoacrylates (CAs) were first described in 1949 and their potential as adhesives were quickly recognised.1 Various homologues of CA adhesive have been studied and used, including methyl-, ethyl-, isobutyl-, isohexyl-, and octyl-CA.1 Commercial CA now has widespread use as an all purpose adhesive in various industries, however the main application of CA is as adhesives domestically. In the early 1960s, the formulation was changed to butyl cyanoacrylate for possible medical use, creating a less toxic product.2 Despite their increasing use in the household, especially medical staff has limited knowledge about the management of adverse effects of CA and that limited knowledge could be ended up with a catastrophe. T this report presents a case of CA glue adhesion and highlights the knowledge of the relevant emergent situation. be457b7860

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