(* the corresponding author; # the mentee in the SILVER lab)
Tong, W.#, Hu, J., ..., Chen, C.*. Air Pollution and Post-Discharge Recovery Among Older Adults Hospitalized for Heart Failure. Under review.
Zhang, Y.#, Shardell, M., Falvey, J., McCoy, R., Stuart, E., Chen, C.*. A Novel Analytical Tool for Evaluating Longitudinal Trajectories in Older Adults with ADRD Using Medicare Claims. Under review.
Shen, B., Zhang, Y., ..., Chen, C.*. A Joint Learning for Analyzing a National Geriatric Centralized Networks: A New Toolbox Deciphering a Real-World Complexity. Invited revision.
Zhao, R.#, Falvey, J., Shi, X., Vernon, C., Chen, C.*. A New Targeted-Federated Learning Framework for Estimating Heterogeneity of Treatment Effects: A Robust Framework with Applications in Aging Cohorts. Under review.
Liang, J., Falvey, J., Chen, S., McCoy, R., Chen, C.*. A Comprehensive Framework for Information Integration in Varying Coefficient Models with Applications to Real-World Data. Under review.
Deng, D.#, Han, P., Chen, S., Wang, M., Chen, C.*. A New Integrative Learning Framework for Integrating Multiple Secondary Outcomes into Primary Outcome Analysis: A Case Study on Liver Health. Under revision.
First/Corresponding Author Publications
(* the corresponding author; # the mentee in the SILVER lab)
Zhao, Z.#, Chen, C.*, Chen., S. (2025) Estimate Time-Varying Exposure Effects via Ensemble Learning-based Marginal Structural Model with Application to Adolescent Cognitive Development Study. Biometrical Journal. Accepted.
Chen, C.*, Chen, S., Ye, Z., Shi, X., Ma, T., Shardell M. (2025) The Effect of Substance Use on Brain White Matter Microstructural Integrity: A New Causal Inference Framework for Incomplete and Massive Phenomic Data. The Journal of the American Statistical Association. In press.
Yu T, Peng M, Cui Y, Chen E, Chen C.*. (2025) Exploring causal effects of hormone-and radio-treatments in an observational study of breast cancer using copula-based semi-competing risks models. Statistics in Medicine. In press.
Deng, D.#, Zhang, L., Feng, H., Chinchilli, V., Chen., C.*, Wang, M. (2025) Improving Estimation Efficiency for Survival Data Analysis by Integrating a Coarsened Time-to-Event Outcome from an External Study. Biometrics. In press.
Chen, C.*, Liang, J., Chen, E., Wang, M. (2025) Advancing Information Integration through Empirical Likelihood: Selective Reviews and a New Idea. Springer Book on Big Data Analysis, Biostatistics and Bioinformatics. In press.
Chen, C., Murphy, T. E., Speiser, J. L., Bandeen-Roche, K., Allore, H., Travison, T. G., ... & Shardell, M. (2025) Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data. The Journals of Gerontology: Series A. 80(1), glae269.
Chen, C., Han, P., Chen, S., Shardell, M., Qin, J. (2024) Integrating External Summary Information in the Presence of Prior Probability Shift: An Application to Assessing Essential Hypertension. Biometrics. 80(3), ujae090.
Liang, J., Chen, S., Kochunov, P., Hong, L.E., Chen, C.* (2024) Integrative data analysis where partial covariates have complex non-linear effects by using summary information from a real-world data. The American Statistician. In press.
Zhang Y.#, Chen S, McCoy R, Chen C.*, Chen Y. (2024). Multi-view k-Nearest Neighbor Graph Contrastive Learning on Multi-modal Biomedical Data. AIME. In press.
Deng, D.; Chinchilli, V.; Feng, H.; Chen, C.*; Wang, M. (2024) Robust Integration of Secondary Data Information into Main Outcome Analysis in the Presence of Missing Data. Statistical Methods in Medical Research. In press.
Shen, B., Ren, H., Shardell, M.,Falvey, J., Chen, C.* (2024) Analyzing Risk Factors for Post-Acute Recovery in Older Adults with Alzheimer’s Disease and Related Dementia: A New Semi-Parametric Model for Large-Scale Medicare Claims. Statistics in Medicine, 43(5):1003-1018.
Chen, C., Chen, S., Long, Q., Das, S., & Wang, M. (2024). Multiple-model-based robust estimation of causal treatment effect on a binary outcome with integrated information from secondary outcomes. The American Statistician, 78(2), 150-160.
Chen, C.*, Wang, M., and Chen, S (2023). An efficient data integration scheme to synthesize information from multiple secondary outcomes to the main data analysis. Biometrics. 79(4):2947–2960.
Chen, C., Shen, B., Wang, M. (2023). ELCIC: An R package for Model Selection Using the Empirical-likelihood Based Information Criterion. Communications for Statistical Applications and Methods. 30.4 (2023): 355-368
Chen, C., Shen, B., Zhang, L., Yu, T., Wang, M., Wu, R. (2023). DRDNetPro: A cartographic tool to predict Disease Risk-associated pseudo-Dynamic Networks from tissue specific gene expression. Bio-protocol, 13(1): e4583.
Chen, C.*, Yu, T., Shen, B, and Wang, M. (2023). Synthesizing secondary data into survival analysis to improve estimation efficiency. Biometrical Journal. 65(3). https://doi.org/10.1002/bimj.202100326.
Chen, C.*, Leung, Y., Ionita, M., Wang, L.-S., and Li, M. (2022). Omnibus and Robust Deconvolution Scheme of Bulk RNA Sequencing Data via Integrating Multiple Single-cell reference sets and Prior Biological Knowledge. Bioinformatics. 38(19), 4530–4536.
Chen, C., Shen,B., Ma, T., Wang, M., and Wu, R. (2022). A statistical learning framework for recovering dynamic networks from static-state data, Bioinformatics. 38(9): 2481-2497.
Chen, C.*, Han, P. and He, F. (2022). Improving main analysis by borrowing information from auxiliary data, Statistics in Medicine. 41(3):567-579.
Chen, C., Jiang, L., Shen, B., Wang, M., Griffin, C., Chinchilli, V., Wu, R. (2021). A Computational Atlas of Tissue-specific Regulatory Networks, Frontiers in Systems Biology. 1:764161. doi:10.3389/fsysb.2021.764161.
Chen, C., Wang, M., Wu, R. and Li, R. (2021). A robust consistent information criterion for model selection based on empirical likelihood, Statistica Sinica. doi:10.5705/ss.202020.0254. (Early version won the student paper award in the 2019 ASA Nonparametric Section.)
Chen, C., Shen, B., Liu, A., Wu, R. and Wang, M. (2020). A multiple robust propensity score method for longitudinal analysis with intermittent missing data, Biometrics, 77(2), 519-532.
Chen, C., Shen, B., Zhang, L., Xue, Y. and Wang, M. (2019). Empirical-likelihood-based criteria for model selection on marginal analysis of longitudinal data with dropout missingness. Biometrics, 75(3), 950-965. (Early version won the student paper award in the 2018 ICSA Applied Statistics Symposium)
Chen, C., Jiang, L., Fu, G., Wang, M., Wang, Y., Shen, B., Liu, Z., Wang, Z., Hou, W., Berceli, S. and Wu, R. (2019). An omnidirectional visualization model of personalized gene regulatory networks, npj Systems Biology and Applications, 5(1), 1-11.
Collaboration Publications
Woodworth, G. F., Anastasiadis, P., Ozair, A., Chen, C., Gandhi, D., Meng, Y., ... & Golby, A. J. (2025). Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound. Device, 100894
Huang, S. J., Robinson-Ector, K. S., Sehgal, N. J., Golden, S. H., Davis, E. M., Ratzki-Leewing, A., Chen, C., ... & McCoy, R. G. (2025). Persistent effects of historical redlining on present day hospital siting and size. Health & Place, 95, 103538.
Ratzki-Leewing, A., Chen, C., & McCoy, R. G. (2025). Reassessing Sulfonylurea Safety in Modern Diabetes Care. JAMA Network Open, 8(7), e2523079-e2523079.
Mehta, R., Falvey, J. R., Chen, C., Dong, Y., Shardell, M. D., Yamashita, T., & Orwig, D. L. (2025). Association Between Prehip Fracture Antidepressant Use and Posthip Fracture Length of Hospital Stay in Medicare Beneficiaries and Assessing Sex Differences. The American Journal of Geriatric Psychiatry, 33(6), 654-663.
Wilhelmy, B., Serra, R., Patel, P., Stokum, J., Hasan, O., Zhao, R., Chen, C., ... & Chryssikos, T. (2025). Reduction of traumatic unilateral locked facet of the subaxial cervical spine: what predicts successful closed skeletal traction, and is anterior or posterior surgery superior after unsuccessful closed reduction?. Journal of Neurosurgery: Spine, 1(aop), 1-11.
Feng, L., Ye, Z., Pan, Y., McCoy, R. G., Mitchell, B. D., Kochunov, P., ... , Chen, C., ..., Ma, T. (2025). Adherence to Life’s Essential 8 is associated with delayed white matter aging. EBioMedicine, 115.
Kim, K. T., Hentschel, M., Zhao, R., Rakovec, M., Han, N., Chen, C., ... & Sansur, C. A. (2025). Increasing pelvic tilt after lumbosacral fusion predicts higher frequency of posttreatment sacroiliac joint fusion. Journal of Neurosurgery: Spine, 1(aop), 1-7.
Han, N., Kim, K. T., Hentschel, M., Zhang, Y., Olexa, J. R., Sharma, A., Chen, C., ... & Sansur, C. A. (2025). 2021 Association of Spinopelvic Parameters With Positive Predictors of Sacroiliac Joint Fusion Success. Neurosurgery, 71(Supplement_1), 246.
Lu, T., Kochunov, P., Chen, C., Huang, H. H., Hong, L. E., & Chen, S. (2025). A New Multiple Imputation Method for High‐Dimensional Neuroimaging Data. Human Brain Mapping, 46(5), e70161.
Shardell, M., & Chen, C. (2025). Genetic geroscience and Alzheimer's disease: The pleiotropy is the point!. Journal of Alzheimer’s Disease, 13872877251321182.
Pan, Y., Bi, C., Kochunov, P., Shardell, M., Smith, J. C., McCoy, R. G., ...,Chen, C.,..., & Chen, S. (2024). Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults. Imaging Neuroscience, 2, 1-15.
McCormick, N., Yokose, C., Lu, N., Wexler, D. J., Aviña-Zubieta, J. A., De Vera, M. A., ...,Chen, C.,..., & Choi, H. K. (2024). Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies. bmj, 387.
Ye, Z., Pan, Y., McCoy, R. G., ..., Chen, C., ..., Chen, S. (2024). Contrasting association pattern of plasma low-density lipoprotein with white matter integrity in APOE4 carriers versus non-carriers. Neurobiology of Aging. 18 (4), 2775-2795.
Wilhelmy, B., Serra, R., Chen, C., Mishra, M., Rodrigues, D., Badjatia, N., ... & Woodworth, G. F. (2024). An analysis of functional outcomes following laser interstitial thermal therapy for recurrent high-grade glioma. Neurosurgical Focus, 57(5), E4.
Pan, Y., Hong, L. E., Acheson, A., Thompson, P. M., Jahanshad, N., Zhu, A. H., ..., Chen, C.,..., & Chen, S. (2024). A Site‐Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms. Human Brain Mapping, 45(16), e70070.
Gandhi, C. K., Depicolzuane, L. C., Chen, C., Roberts, C. M., Sicher, N., Johnson Wegerson, K., ... & Floros, J. (2024). Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children. Physiological Genomics. In press.
Lee H, Chen C., Kochunov P, Hong E, Chen S. (2024). A New Multiple-mediator Model Maximally Uncovering the Mediation Pathway: Evaluating the Role of Neuroimaging Measures in Age-Related Cognitive Decline. Annuals of Applied Statistics, In press.
Lutz G, Yang Y, Zhang Y, Chen C., Kheirbek R. (2024). A Tale of Two Experiences: Navigating End of Life Care with a History of Incarceration. The Journal of Gerontology: Medical Sciences. In press.
Mehta, R., Orwig, D. L., Chen, C., Dong, Y., Shardell, M. D., Yamashita, T., & Falvey, J. R. (2024). Association between pre‐hip fracture depression and days at home after fracture and assessing sex differences. Journal of the American Geriatrics Society. In press.
Shardell, M., Chen, C., McCoy, RG. (2024). Doubly robust causal modeling: An application of the technique to evaluate device implantation. JAMA Internal Med, In press.
Pillai, J., Wu, H., Tang, W., Feng, H., Chen, C., Leverenz, J., & Wang, M. (2024). Cognitive and Behavioral Subtypes of Alzheimer’s and Lewy Body Dementias with Distinct Clinical Characteristics (P3-9.003). In Neurology (Vol. 102, No. 17_supplement_1, p. 5199). Hagerstown, MD: Lippincott Williams & Wilkins.
Wu, X., Chen, C., Li, Z., Zhang, L., Chinchilli, V. M., & Wang, M. (2024). A three-stage approach to identify biomarker signatures for cancer genetic data with survival endpoints. Statistical Methods & Applications, In press.
Yang, Y., Chen, C., & Chen, S. (2024). Covariance matrix estimation for high-throughput biomedical data with interconnected communities. The American Statistician, (accepted), 1-19.
Kardon, A., Kim, D., Ren, H., Jaffa, M. N., Elsaesser, D., ..., Chen, C., ... & Morris, N. A. (2024). A Propensity Score–Weighted Analysis of Short-Term Corticosteroid Therapy for Refractory Pain Following Spontaneous Subarachnoid Hemorrhage. Neurocritical Care, 1-9.
Albrecht, J. S., Chen, C., & Falvey, J. (2024). Trajectories of recovery following traumatic brain injury among older Medicare beneficiaries. Journal of neurotrauma. Accepted.
Serra, R., Wilhelmy, B., Chen, C., Oliver, J. D., Stokum, J. A., Bodanapally, U. K., ... & Aarabi, B. (2024). Acute Development of Traumatic Intracranial Aneurysms Following Civilian Gunshot Wounds to the Head. Journal of Neurotrauma. Accepted.
Olexa, J., Walek, K. W., Flessner, R., Trang, A., Stokum, J., Chen, C., ... & Schwartzbauer, G. (2024). The Neurosurgeon's Dilemma—Do Antiplatelet/Anticoagulant Medications Increase the Risk of Catheter-Associated Hemorrhage in External Ventricular Drain Placement? World Neurosurgery. Accepted.
Walek, K., Trang, A., Bodanapally, U., Olexa, J. R., Chen, C., Morales, W., ... & Aarabi, B. (2024). 438 Lesion Combination on Susceptibility-Weighted MRI Predicts Functional Recovery After Diffuse Axonal Injury. Neurosurgery, 70(Supplement_1), 133.
Hammer, D. X., Kovalick, K., Liu, Z., Chen, C., Saeedi, O. J., & Harrison, D. M. (2023). Cellular-Level Visualization of Retinal Pathology in Multiple Sclerosis With Adaptive Optics. Investigative Ophthalmology & Visual Science, 64(14): 21-21.
Feng, L., Ye, Z., Mo, C., Wang, J., Liu, S., Gao, S., ...Chen, C.,..., & Ma, T. (2023). Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank. Journal of Hypertension, 41(11): 1811-1820.
Kambouris, A. R., Brammer, J. A., Roussey, H., Chen, C., & Cross, A. S. A combination of burn wound injury and Pseudomonas infection elicits unique gene expression that enhances bacterial pathogenicity. mBio, e0245423.
Carney, C. P., Pandey, N., Kapur, A., Saadi, H., Ong, H. L., Chen, C., ... & Kim, A. J. (2023). Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells. ACS nano. Accepted.
Yang, Y., Lutz, G., Zhang, Y., Chen, C., & Kheirbek, R. E. (2023). The Hidden Toll of Incarceration: Exploring the Link Between Incarceration Histories and Pain Among Older Adults in the United States. Innovation in Aging, igad116.
Falvey, J., Chen, C., …, Shardell, M., and among others. (2023) Associations of Days Spent at Home Before Hip Fracture With Post-Fracture Days at Home and 1-Year Mortality Among Medicare Beneficiaries Living with Alzheimer’s Disease or Related Dementias. The Journals of Gerontology: Series A. 78(12):2356-2362.
Ahmed, A., ..., Chen, C., ..., Woodworth, G. (2023). Variability in the arterial supply of intracranial meningiomas: an anatomic study. Neurosurgery. 10-1227. PMID: 37530524.
Ye, Z.,..., Chen, C.,..., Ma, T. (2023). Deciphering the causal relationship between blood pressure and regional white matter integrity: a two-sample Mendelian randomization study. Journal of Neuroscience Research. 101(9):1471-1483..
Zhao, Z., Chen, C., Adhikari, B. M., Hong, L. E., Kochunov, P., & Chen, S. (2023). Mediation analysis for high-dimensional mediators and outcomes with an application to multimodal imaging data. Computational Statistics & Data Analysis, 185: 107765.
Ahmed, A. K., Zhuo, J., Gullapalli, R. P., Jiang, L., Keaser, M. L., Greenspan, J. D., ...Chen, C.,... & Gandhi, D. (2022). Focused ultrasound central lateral thalamotomy for the treatment of refractory neuropathic pain: phase I trial. Neurosurgery, 10-1227.
Ksendzovsky, A., ..., Chen, C.,... (2022) Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway. Brain Communications, 5(1), fcac298.
Mo C., Wang J., Ye Z., Ke H., Liu S., Hatch K., Gao S., Magidson J., Chen C., Mitchell BD., Kochunov P., Hong L.E., Chen, S. and Ma, T., (2022). Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank. Addiction, 118(4): 739-749.
Carney, C. ..., Chen, C., ..., Kim, A. (2022). Fn14-directed DART nanoparticles selectively target neoplastic cells in preclinical models of triple negative breast cancer brain metastasis. Molecular Pharmaceutics. 20(1):314-330.
Chryssikos, T., Chen, C., ... (2022). Surgical decompression of traumatic cervical spinal cord injury: a pilot study comparing real-time intraoperative ultrasound with postoperative mri and ct myelography. Neurosurgery, 92(2): 353-362.
Spina, R., Mills, I., Ahmad, F., Chen, C., Ames, H. M., Winkles, J. A., ... & Bar, E. E. (2022). DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts. Oncogene, 1-12.
Aarabi, B., Chen, C., et al. (2022). Proposal of a Management Algorithm to Predict the Need for Expansion Duraplasty in AIS Grades AC Traumatic Cervical Spinal Cord Injury Patients. Journal of Neurotrauma. 39, 1–11.
Lee, H., Chen, C., Kochunov, P., Hong, E., Chen, S. (2022) Modeling multivariate age-related imaging variables with dependencies. Statistics in Medicine. 41(22), 4484-4500.
Abbasi, A., Chen, C., et al. (2022) Single nucleotide polymorphisms (SNP) and SNP-SNP interactions of the surfactant protein genes are associated with idiopathic Pulmonary Fibrosis in a Mexican study group; Comparison with Hypersensitivity Pneumonitis. Frontiers in Immunology, section Molecular Innate Immunity. 13: 842745.
Shen, B., Chen, C., Wang M. (2022). Semiparametric marginal methods for clustered data adjusting for informative cluster size with non-ignorable zeros. Biometrical Journal. 64(5), 898-911.
Ye, Z.,, Chen, M., Ke, H., Yan, Q., Chen, C., Hong, E., Kochunov, P., Mitchell, B., Chen, S., Ma, T. (2021) Meta-analysis of transcriptome-wide association studies across 13 brain tissues identified novel clusters of genes associated with nicotine addiction. Genes. 13(1), 31.
Shen, B., Chen, C., Liu, D., Datta, S., Ghahramani, N., Chinchilli, V. M. and Wang, M. (2021). A Joint modeling of longitudinal data with informative cluster size adjusted for zero-inflation and a dependent terminal event. Statistics in Medicine, 40(21), 4582-4596.
Gandhi, C. K., Chen, C., Amatya, S., Yang, L., Fu, C., Zhou, S., Wu, R., Buendía-Roldan, I., Selman, M., Pardo, A. A., and Floros, J. (2021). SNP and haplotype interaction models reveal association of surfactant protein gene polymorphisms with hypersensitivity pneumonitis of Mexican population. Frontiers in Medicine, 7, 1043.
Hu, J., Schroeder, A., Coleman, K., Chen, C., Auerbach, B. J. , Li, M. (2021). Statistical and Machine Learning Methods for Spatially Resolved Transcriptomics. Computational and Structural Biotechnology Journal, 19, 3829-3841.
Gandhi, C. K., Chen, C., Wu, R., Thorenoor, N., Thomas, N. J., DiAngelo, S. L., Spear, D., Keim, G., Yehya, N. and Floros, J. (2020). Association of SNP-SNP interactions of surfactant protein genes with pediatric acute respiratory failure in a three-SNP model. Journal of clinical medicine, 9(4), 1183.
Wang, M., Long, Q., Chen, C. and Zhang, L. (2020). Assessing predictive accuracy of survival regressions subject to non-independent censoring, Statistics in Medicine, 39(4), 469-480.
Bluethmann, S., Wang, M., Wasserman, E., Chen, C., Zaorsky, N., Hohl, R. and McDonald, A. (2020). Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. Cancer Medicine, 9(10), 3623-3633.
Shen, B., Dunker, F. and Chen, C. (2019). Simultaneous confidence bands for growth incidence curves in weighted sup-norm metrics. Statistics. 53(6), 1269-1288.
Zeng, Y., Zhu, X., Chen, C., Banerjee, K., Sun, L., Yu, W., Zheng, B. and Wu, R. (2019). A unified DNA sequence and non‐ DNA sequence mapping model of complex traits. The Plant Journal, 99(4), 784-795.
Ye, M., Jiang, L., Chen, C., Zhu X., Wang M. and Wu, R. (2019). Networking phenotypic plasticity QTLs across hetero-geneous environments. The Plant Journal, 99(4), 796-806.
Gardner, A., Montgomery, P., Wang, M., Chen, C., Kuroki, M. and Kim, D. (2019). Vascular inflammation, calf muscle oxygen saturation, and blood glucose are associated with exercise pressor response in symptomatic peripheral artery disease. Angiology, 70(8), 747-755.
Gardner, A., Montgomery, P., Wang, M., Chen, C., Kuroki, M. and Kim, D. (2019). Greater exercise pressor response is associated with impaired claudication outcomes in symptomatic peripheral artery disease. Angiology, 70(3), 220-228.
Weeramange, C., Binns, C., Chen, C. and Rafferty, R. (2018). Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity. Journal of Pharmaceutical and Biomedical Analysis, 151, 106-115.
Craig, J., Broxterman, R., Wilcox, S., Chen, C. and Barstow, T. (2017). Effect of adipose tissue thickness, muscle site, and sex on near-infrared spectroscopy derived total-[Hemoglobin + Myoglobin]. Journal of Applied Physiology, 123(6), 1571-1578.