Publications
SelectIVE papers under review/revision:
* the corresponding author
Chen, C.*, Liang, J., Chen, E., Wang, M., Advancing Information Integration through Empirical Likelihood: Selective Reviews and a New Idea, Under review.
Chen, C., Shardell, M., Speiser, J. L., Bandeen-Roche, K., Allore, H., Travison, T. G., ... & Murphy, T. E. (2024). Gerontologic Biostatistics 2.0: Developments over 10+ years in the age of data science. Under revision.
Chen, C., Han, P., Chen, S., Shardell, M., Qin, J., Integrating External Summary Information in the Presence of Prior Probability Shift: An Application to Assessing Essential Hypertension. Under revision.
Deng, D., Zhang, L., Feng, H., Chinchilli, V., Wang, M., Chen., C.*, Improving Estimation Efficiency for Survival Data Analysis by Integrating a Coarsened Time-to-Event Outcome from an External Study. Under revision.
Chen, C.*, Chen, S., Ye, Z., Shi, X., Ma, T. The Effect of Substance Use on Brain Ageing: A New Causal Inference Framework for Incomplete and Massive Phenomic Data. Under revision.
Peer-reviewed Publications:
First/Corresponding Author Publications
* the corresponding author
Liang, J., Chen, S., Kochunov, P., Hong, L.E., Chen, C.* (2024) Integrative data analysis where partial covariates have complex non-linear effects by using summary information from a real-world data. The American Statistician. Accepted.
Deng, D.; Chinchilli, V.; Feng, H.; Chen, C.*; Wang, M.* (2024) Robust Integration of Secondary Data Information into Main Outcome Analysis in the Presence of Missing Data. Statistical Methods in Medical Research. Accepted.
Shen, B., Ren, H., Shardell, M.,Falvey, J., Chen, C.* (2024) Analyzing Risk Factors for Post-Acute Recovery in Older Adults with Alzheimer’s Disease and Related Dementia: A New Semi-Parametric Model for Large-Scale Medicare Claims. Statistics in Medicine, 43(5):1003-1018.
Chen, C., Chen, S., Long, Q., Das, S., & Wang, M. (2024). Multiple-model-based robust estimation of causal treatment effect on a binary outcome with integrated information from secondary outcomes. The American Statistician, 78(2), 150-160.
Chen, C.*, Wang, M., and Chen, S (2023). An efficient data integration scheme to synthesize information from multiple secondary outcomes to the main data analysis. Biometrics. 79(4):2947–2960.
Chen, C., Shen, B., Wang, M. (2023). ELCIC: An R package for Model Selection Using the Empirical-likelihood Based Information Criterion. Communications for Statistical Applications and Methods. 30.4 (2023): 355-368
Chen, C., Shen, B., Zhang, L., Yu, T., Wang, M., Wu, R. (2023). DRDNetPro: A cartographic tool to predict Disease Risk-associated pseudo-Dynamic Networks from tissue specific gene expression. Bio-protocol, 13(1): e4583.
Chen, C.*, Yu, T., Shen, B, and Wang, M. (2023). Synthesizing secondary data into survival analysis to improve estimation efficiency. Biometrical Journal. 65(3). https://doi.org/10.1002/bimj.202100326.
Chen, C.*, Leung, Y., Ionita, M., Wang, L.-S., and Li, M. (2022). Omnibus and Robust Deconvolution Scheme of Bulk RNA Sequencing Data via Integrating Multiple Single-cell reference sets and Prior Biological Knowledge. Bioinformatics. 38(19), 4530–4536.
Chen, C., Shen,B., Ma, T., Wang, M., and Wu, R. (2022). A statistical learning framework for recovering dynamic networks from static-state data, Bioinformatics. 38(9): 2481-2497.
Chen, C.*, Han, P. and He, F. (2022). Improving main analysis by borrowing information from auxiliary data, Statistics in Medicine. 41(3):567-579.
Chen, C., Jiang, L., Shen, B., Wang, M., Griffin, C., Chinchilli, V., Wu, R. (2021). A Computational Atlas of Tissue-specific Regulatory Networks, Frontiers in Systems Biology. 1:764161. doi:10.3389/fsysb.2021.764161.
Chen, C., Wang, M., Wu, R. and Li, R. (2021). A robust consistent information criterion for model selection based on empirical likelihood, Statistica Sinica. doi:10.5705/ss.202020.0254. (Early version won the student paper award in the 2019 ASA Nonparametric Section.)
Chen, C., Shen, B., Liu, A., Wu, R. and Wang, M. (2020). A multiple robust propensity score method for longitudinal analysis with intermittent missing data, Biometrics, 77(2), 519-532.
Chen, C., Shen, B., Zhang, L., Xue, Y. and Wang, M. (2019). Empirical-likelihood-based criteria for model selection on marginal analysis of longitudinal data with dropout missingness. Biometrics, 75(3), 950-965. (Early version won the student paper award in the 2018 ICSA Applied Statistics Symposium)
Chen, C., Jiang, L., Fu, G., Wang, M., Wang, Y., Shen, B., Liu, Z., Wang, Z., Hou, W., Berceli, S. and Wu, R. (2019). An omnidirectional visualization model of personalized gene regulatory networks, npj Systems Biology and Applications, 5(1), 1-11.
Collaboration Publications
Shardell, M., Chen, C., McCoy, RG. (2024). Doubly robust causal modeling: An application of the technique to evaluate device implantation. JAMA Internal Med, In press.
Pillai, J., Wu, H., Tang, W., Feng, H., Chen, C., Leverenz, J., & Wang, M. (2024). Cognitive and Behavioral Subtypes of Alzheimer’s and Lewy Body Dementias with Distinct Clinical Characteristics (P3-9.003). In Neurology (Vol. 102, No. 17_supplement_1, p. 5199). Hagerstown, MD: Lippincott Williams & Wilkins.
Wu, X., Chen, C., Li, Z., Zhang, L., Chinchilli, V. M., & Wang, M. (2024). A three-stage approach to identify biomarker signatures for cancer genetic data with survival endpoints. Statistical Methods & Applications, In press.
Yang, Y., Chen, C., & Chen, S. (2024). Covariance matrix estimation for high-throughput biomedical data with interconnected communities. The American Statistician, (accepted), 1-19.
Albrecht, J. S., Chen, C., & Falvey, J. (2024). Trajectories of recovery following traumatic brain injury among older Medicare beneficiaries. Journal of neurotrauma. Accepted.
Serra, R., Wilhelmy, B., Chen, C., Oliver, J. D., Stokum, J. A., Bodanapally, U. K., ... & Aarabi, B. (2024). Acute Development of Traumatic Intracranial Aneurysms Following Civilian Gunshot Wounds to the Head. Journal of Neurotrauma. Accepted.
Olexa, J., Walek, K. W., Flessner, R., Trang, A., Stokum, J., Chen, C., ... & Schwartzbauer, G. (2024). The Neurosurgeon's Dilemma—Do Antiplatelet/Anticoagulant Medications Increase the Risk of Catheter-Associated Hemorrhage in External Ventricular Drain Placement? World Neurosurgery. Accepted.
Walek, K., Trang, A., Bodanapally, U., Olexa, J. R., Chen, C., Morales, W., ... & Aarabi, B. (2024). 438 Lesion Combination on Susceptibility-Weighted MRI Predicts Functional Recovery After Diffuse Axonal Injury. Neurosurgery, 70(Supplement_1), 133.
Hammer, D. X., Kovalick, K., Liu, Z., Chen, C., Saeedi, O. J., & Harrison, D. M. (2023). Cellular-Level Visualization of Retinal Pathology in Multiple Sclerosis With Adaptive Optics. Investigative Ophthalmology & Visual Science, 64(14): 21-21.
Feng, L., Ye, Z., Mo, C., Wang, J., Liu, S., Gao, S., ...Chen, C.,..., & Ma, T. (2023). Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank. Journal of Hypertension, 41(11): 1811-1820.
Kambouris, A. R., Brammer, J. A., Roussey, H., Chen, C., & Cross, A. S. A combination of burn wound injury and Pseudomonas infection elicits unique gene expression that enhances bacterial pathogenicity. mBio, e0245423.
Carney, C. P., Pandey, N., Kapur, A., Saadi, H., Ong, H. L., Chen, C., ... & Kim, A. J. (2023). Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells. ACS nano. Accepted.
Yang, Y., Lutz, G., Zhang, Y., Chen, C., & Kheirbek, R. E. (2023). The Hidden Toll of Incarceration: Exploring the Link Between Incarceration Histories and Pain Among Older Adults in the United States. Innovation in Aging, igad116.
Falvey, J., Chen, C., …, Shardell, M., and among others. (2023) Associations of Days Spent at Home Before Hip Fracture With Post-Fracture Days at Home and 1-Year Mortality Among Medicare Beneficiaries Living with Alzheimer’s Disease or Related Dementias. The Journals of Gerontology: Series A. 78(12):2356-2362.
Ahmed, A., ..., Chen, C., ..., Woodworth, G. (2023). Variability in the arterial supply of intracranial meningiomas: an anatomic study. Neurosurgery. 10-1227. PMID: 37530524.
Ye, Z.,..., Chen, C.,..., Ma, T. (2023). Deciphering the causal relationship between blood pressure and regional white matter integrity: a two-sample Mendelian randomization study. Journal of Neuroscience Research. 101(9):1471-1483..
Zhao, Z., Chen, C., Adhikari, B. M., Hong, L. E., Kochunov, P., & Chen, S. (2023). Mediation analysis for high-dimensional mediators and outcomes with an application to multimodal imaging data. Computational Statistics & Data Analysis, 185: 107765.
Ahmed, A. K., Zhuo, J., Gullapalli, R. P., Jiang, L., Keaser, M. L., Greenspan, J. D., ...Chen, C.,... & Gandhi, D. (2022). Focused ultrasound central lateral thalamotomy for the treatment of refractory neuropathic pain: phase I trial. Neurosurgery, 10-1227.
Ksendzovsky, A., ..., Chen, C.,... (2022) Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway. Brain Communications, 5(1), fcac298.
Mo C., Wang J., Ye Z., Ke H., Liu S., Hatch K., Gao S., Magidson J., Chen C., Mitchell BD., Kochunov P., Hong L.E., Chen, S. and Ma, T., (2022). Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank. Addiction, 118(4): 739-749.
Carney, C. ..., Chen, C., ..., Kim, A. (2022). Fn14-directed DART nanoparticles selectively target neoplastic cells in preclinical models of triple negative breast cancer brain metastasis. Molecular Pharmaceutics. 20(1):314-330.
Chryssikos, T., Chen, C., ... (2022). Surgical decompression of traumatic cervical spinal cord injury: a pilot study comparing real-time intraoperative ultrasound with postoperative mri and ct myelography. Neurosurgery, 92(2): 353-362.
Spina, R., Mills, I., Ahmad, F., Chen, C., Ames, H. M., Winkles, J. A., ... & Bar, E. E. (2022). DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts. Oncogene, 1-12.
Aarabi, B., Chen, C., et al. (2022). Proposal of a Management Algorithm to Predict the Need for Expansion Duraplasty in AIS Grades AC Traumatic Cervical Spinal Cord Injury Patients. Journal of Neurotrauma. 39, 1–11.
Lee, H., Chen, C., Kochunov, P., Hong, E., Chen, S. (2022) Modeling multivariate age-related imaging variables with dependencies. Statistics in Medicine. 41(22), 4484-4500.
Abbasi, A., Chen, C., et al. (2022) Single nucleotide polymorphisms (SNP) and SNP-SNP interactions of the surfactant protein genes are associated with idiopathic Pulmonary Fibrosis in a Mexican study group; Comparison with Hypersensitivity Pneumonitis. Frontiers in Immunology, section Molecular Innate Immunity. 13: 842745.
Shen, B., Chen, C., Wang M. (2022). Semiparametric marginal methods for clustered data adjusting for informative cluster size with non-ignorable zeros. Biometrical Journal. 64(5), 898-911.
Ye, Z.,, Chen, M., Ke, H., Yan, Q., Chen, C., Hong, E., Kochunov, P., Mitchell, B., Chen, S., Ma, T. (2021) Meta-analysis of transcriptome-wide association studies across 13 brain tissues identified novel clusters of genes associated with nicotine addiction. Genes. 13(1), 31.
Shen, B., Chen, C., Liu, D., Datta, S., Ghahramani, N., Chinchilli, V. M. and Wang, M. (2021). A Joint modeling of longitudinal data with informative cluster size adjusted for zero-inflation and a dependent terminal event. Statistics in Medicine, 40(21), 4582-4596.
Gandhi, C. K., Chen, C., Amatya, S., Yang, L., Fu, C., Zhou, S., Wu, R., Buendía-Roldan, I., Selman, M., Pardo, A. A., and Floros, J. (2021). SNP and haplotype interaction models reveal association of surfactant protein gene polymorphisms with hypersensitivity pneumonitis of Mexican population. Frontiers in Medicine, 7, 1043.
Hu, J., Schroeder, A., Coleman, K., Chen, C., Auerbach, B. J. , Li, M. (2021). Statistical and Machine Learning Methods for Spatially Resolved Transcriptomics. Computational and Structural Biotechnology Journal, 19, 3829-3841.
Gandhi, C. K., Chen, C., Wu, R., Thorenoor, N., Thomas, N. J., DiAngelo, S. L., Spear, D., Keim, G., Yehya, N. and Floros, J. (2020). Association of SNP-SNP interactions of surfactant protein genes with pediatric acute respiratory failure in a three-SNP model. Journal of clinical medicine, 9(4), 1183.
Wang, M., Long, Q., Chen, C. and Zhang, L. (2020). Assessing predictive accuracy of survival regressions subject to non-independent censoring, Statistics in Medicine, 39(4), 469-480.
Bluethmann, S., Wang, M., Wasserman, E., Chen, C., Zaorsky, N., Hohl, R. and McDonald, A. (2020). Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. Cancer Medicine, 9(10), 3623-3633.
Shen, B., Dunker, F. and Chen, C. (2019). Simultaneous confidence bands for growth incidence curves in weighted sup-norm metrics. Statistics. 53(6), 1269-1288.
Zeng, Y., Zhu, X., Chen, C., Banerjee, K., Sun, L., Yu, W., Zheng, B. and Wu, R. (2019). A unified DNA sequence and non‐ DNA sequence mapping model of complex traits. The Plant Journal, 99(4), 784-795.
Ye, M., Jiang, L., Chen, C., Zhu X., Wang M. and Wu, R. (2019). Networking phenotypic plasticity QTLs across hetero-geneous environments. The Plant Journal, 99(4), 796-806.
Gardner, A., Montgomery, P., Wang, M., Chen, C., Kuroki, M. and Kim, D. (2019). Vascular inflammation, calf muscle oxygen saturation, and blood glucose are associated with exercise pressor response in symptomatic peripheral artery disease. Angiology, 70(8), 747-755.
Gardner, A., Montgomery, P., Wang, M., Chen, C., Kuroki, M. and Kim, D. (2019). Greater exercise pressor response is associated with impaired claudication outcomes in symptomatic peripheral artery disease. Angiology, 70(3), 220-228.
Weeramange, C., Binns, C., Chen, C. and Rafferty, R. (2018). Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity. Journal of Pharmaceutical and Biomedical Analysis, 151, 106-115.
Craig, J., Broxterman, R., Wilcox, S., Chen, C. and Barstow, T. (2017). Effect of adipose tissue thickness, muscle site, and sex on near-infrared spectroscopy derived total-[Hemoglobin + Myoglobin]. Journal of Applied Physiology, 123(6), 1571-1578.