主要な論文

Suzuki M, Gonda Y, Yamada M, Vandebroek AA, Mita M, Hamase K, Yasui M, Sasabe J*.

Serum D-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1.

Sci Rep. 2019 Nov 13;9(1):16705. doi: 10.1038/s41598-019-53302-2.

Sasabe J*, Suzuki M.

Emerging Role of D-Amino Acid Metabolism in the Innate Defense.

Front Microbiol. 2018 May 9;9:933. doi: 10.3389/fmicb.2018.00933.

Sasabe J*, Suzuki M.

Distinctive Roles of D-Amino Acids in the Homochiral World: Chirality of Amino Acids Modulates Mammalian Physiology and Pathology.

Keio J Med. 2018 May 22. doi: 10.2302/kjm.2018-0001-IR.

Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK.

Deciphering the landscape of host barriers to Listeria monocytogenes infection.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6334-6339. doi: 10.1073/pnas.1702077114.

Suzuki M, Imanishi N, Mita M, Hamase K, Aiso S, Sasabe J*.

Heterogeneity of D-Serine Distribution in the Human Central Nervous System.

ASN Neuro. 2017 May-Jun;9(3):1759091417713905. doi: 10.1177/1759091417713905.

Sasabe J, Miyoshi Y, Rakoff-Nahoum S, Zhang T, Mita M, Davis BM, Hamase K, Waldor MK.

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota.

Nat Microbiol. 2016 Jul 25;1(10):16125. doi: 10.1038/nmicrobiol.2016.125.

This paper was highlighted in

Host–microbe interactions: DAO does it (Nature Chemical Biology volume 12, page 763 (2016)

Gut microbiota: D-amino acids employed against gut pathogens (Nature Reviews Gastroenterology & Hepatology volume 13, page 499 (2016)

D-アミノ酸による腸内細菌と宿主哺乳類の相互作用（Nature Japan Interview）(2016)

Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK.

Chemoproteomic profiling of host and pathogen enzymes active in cholera.

Nat Chem Biol. 2016 Apr;12(4):268-274. doi: 10.1038/nchembio.2025.

Sasabe J*, Sadakazu Aiso.

Abnormal D-serine metabolism in amyotrophic lateral sclerosis.

D-Amino Acids. 2016 chapter 9:137-149.

Ito T, Takada H, Isobe K, Suzuki M, Kitaura Y, Hemmi H, Matsuda T, Sasabe J, Yoshimura T.

PEGylated D-serine dehydratase as a D-serine reducing agent.

J Pharm Biomed Anal. 2015 Dec 10;116:34-9. doi: 10.1016/j.jpba.2014.12.044.

Wang Q, Millet YA, Chao MC, Sasabe J, Davis BM, Waldor MK.

A Genome-Wide Screen Reveals that the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System Modulates Virulence Gene Expression.

Infect Immun. 2015 Sep;83(9):3381-95. doi: 10.1128/IAI.00411-15.

Suzuki M, Sasabe J*, Miyoshi Y, Kuwasako K, Muto Y, Hamase K, Matsuoka M, Imanishi N, Aiso S.

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2217-24. doi: 10.1073/pnas.1416117112.

Yamaichi Y, Chao MC, Sasabe J, Clark L, Davis BM, Yamamoto N, Mori H, Kurokawa K, Waldor MK.

High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4.

Nucleic Acids Res. 2015 Jan;43(1):348-60. doi: 10.1093/nar/gku1262.

Abe T, Suzuki M, Sasabe J, Takahashi S, Unekawa M, Mashima K, Iizumi T, Hamase K, Konno R, Aiso S, Suzuki N.

Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.

J Cereb Blood Flow Metab. 2014 Dec;34(12):1928-35. doi: 10.1038/jcbfm.2014.164.

Sasabe J*, Suzuki M, Imanishi N, Aiso S.

Activity of D-amino acid oxidase is widespread in the human central nervous system.

Front Synaptic Neurosci. 2014 Jun 10;6:14. doi: 10.3389/fnsyn.2014.00014.

Sasabe J*, Suzuki M, Miyoshi Y, Tojo Y, Okamura C, Ito S, Konno R, Mita M, Hamase K, Aiso S.

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers.

PLoS One. 2014 Jan 29;9(1):e86504. doi: 10.1371/journal.pone.0086504.

Miyoshi Y, Konno R, Sasabe J, Ueno K, Tojo Y, Mita M, Aiso S, Hamase K.

Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase.

Amino Acids. 2012 Nov;43(5):1919-31. doi: 10.1007/s00726-012-1398-4.

Suzuki M, Sasabe J*, Furuya S, Mita M, Hamase K, Aiso S.

Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.

Brain Res. 2012 Jul 23;1466:167-76. doi: 10.1016/j.brainres.2012.05.042.

Hayashi K, Sasabe J, Chiba T, Aiso S, Utsunomiya-Tate N.

D-Ser-containing humanin shows promotion of fibril formation.

Amino Acids. 2012 Jun;42(6):2293-7. doi: 10.1007/s00726-011-0971-6.

Sasabe J*, Miyoshi Y, Suzuki M, Mita M, Konno R, Matsuoka M, Hamase K, Aiso S.

D-amino acid oxidase controls motoneuron degeneration through D-serine.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):627-32. doi: 10.1073/pnas.1114639109.

Sasabe J*, Aiso S.

Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis: excitatory glutamate/D-serine vs. inhibitory glycine/gamma-aminobutanoic acid (GABA).

Chem Biodivers. 2010 Jun;7(6):1479-90. doi: 10.1002/cbdv.200900306.

Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S.

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

Mol Psychiatry. 2009 Feb;14(2):206-22. doi: 10.1038/mp.2008.105.

Yamada M, Chiba T, Sasabe J, Terashita K, Aiso S, Matsuoka M.

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.

Neuropsychopharmacology. 2008 Jul;33(8):2020-32.

Sasabe J, Chiba T, Yamada M, Okamoto K, Nishimoto I, Matsuoka M, Aiso S.

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.

EMBO J. 2007 Sep 19;26(18):4149-59.

Chiba T, Yamada M, Sasabe J, Terashita K, Aiso S, Matsuoka M, Nishimoto I.

Colivelin prolongs survival of an ALS model mouse.

Biochem Biophys Res Commun. 2006 May 12;343(3):793-8.

Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M, Nishimoto I.

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.

Behav Brain Res. 2005 Nov 7;164(2):139-46.

Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M.

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.

J Neurosci. 2005 Nov 2;25(44):10252-61.

Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I, Matsuoka M.

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.

J Biol Chem. 2005 Feb 11;280(6):4532-43.