(Project in Dissertation | Aug'18 - Dec'18)
Inspired by the potential of Lung-on-a-chip technology, I decided to explore the field of biomechanics for my undergrad dissertation.
The research aimed towards simulating an artery by casting a mold using Polydimethylsiloxane (PDMS) polymer, in order to study the dependence of atherosclerosis on the bifurcation angle of an artery. Further study will involve inoculating endothelial cells in the microfluidic device and understanding the variations in shear stress acting on the cells which in turn gives a better understanding of the plaque formation.
The steps involved in making the microfluidic device included:
Precise construction of a metal frame to imprint the arteries in PDMS (Diameter of 2mm, bifurcation angle of 30°)
Meticulously following the PDMS curing protocol
Degasification using a vacuum desiccator to remove any air bubbles generated during the curing process
Sealing the microfluidic device onto a glass plate
(Click here for the slide deck of the project)