Publications

Suchit Ahuja, Cynthia Adjekukor, Qing Li, Katrinka M. Kocha, Nicole Rosin, Elodie Labit, Sarthak Sinha, Ankita Narang, Quan Long, Jeff Biernaskie, Peng Huang, Sarah J. Childs A genetic program for vascular pericyte precursors  bioRxiv 2023.06.21.545941; doi: https://doi.org/10.1101/2023.06.21.545941

Vanden Broek K, Ryu JR, Perrier R, Tyndall AV, Childs SJ, Au PYB. SAM domain variants of EPHB4 associated with aberrant signaling are linked to lymphatic-related fetal hydrops and facial dysmorphology.  Clin Genet. 2023 Dec 27. doi: 10.1111/cge.14467. PMID: 38151336

McGarry SD, Adjekukor C, Ahuja S, Greysson-Wong J, Vien I, Rinker KD, Childs SJ. Vessel Metrics: A software tool for automated analysis of vascular structure in confocal imaging. Microvasc Res. 2024 Jan;151:104610. doi: 10.1016/j.mvr.2023.104610. PMID: 37739214

Jasper Greysson-Wong, Rachael Rode, Jae-Ryeon Ryu, Jo Li Chan, Paniz Davari, Kristina D Rinker, Sarah J Childs. rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development, 2023 Sep 15;150(18):dev201820. doi: 10.1242/dev.201820

Ryu JR, Ahuja S, Arnold CR, Potts KG, Mishra A, Yang Q, Sargurupremraj M, Mahoney DJ, Seshadri S, Debette S, Childs SJ. , Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2121333119. doi: 10.1073/pnas.2121333119. 

PMID: 35994645 

Zink M, Seewald A, Rohrbach M, Brodehl A, Liedtke D, Williams T, Childs SJ, Gerull B,  Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish. Int J Mol Sci. 2022 Aug 23;23(17):9530. doi: 10.3390/ijms23179530.,PMID: 36076925 

Danielle L. Blackwell, Jillian S. Parboosingh, Micheil Innes, Sherri D. Fraser, Oana Caluseriu,Claudia Vivori,Francois P. Bernier, AmandaV.Tyndall, Ryan E. Lamont, and Sarah J.Childs. Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3. 2022, jkac067, PMID: 35325113.

Watterston C, Halabi R, McFarlane S, Childs SJ. Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genet. 2021 Aug 23;17(8):e1009769.

Halabi R, Watterston C, Hehr CL, Mori-Kreiner R, Childs SJ, McFarlane S. Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):21. doi: 10.1167/iovs.62.2.21. PMID: 33595613 

Bahrami N, Childs SJ. Development of vascular regulation in the zebrafish embryo. Development. 2020 May 18;147(10):dev183061. PMID: 32423977

Whitesell TR, Chrystal PW, Ryu JR, Munsie N, Grosse A, French CR, Workentine ML, Li R, Zhu LJ, Waskiewicz A, Lehmann OJ, Lawson ND, Childs SJ. foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Dev Biol. 2019 Sep 1;453(1):34-47. Epub 2019 Jun 11.PMID: 31199900 

Watterston C, Zeng L, Onabadejo A, Childs SJ. MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling. PLoS Genet. 2019 May 15;15(5):e1008163. eCollection 2019 May.PMID: 31091229 

Brodehl A, Rezazadeh S, Williams T, Munsie NM, Liedtke D, Oh T, Ferrier R, Shen Y, Jones SJM, Stiegler AL, Boggon TJ, Duff HJ, Friedman JM, Gibson WT; FORGE Canada Consortium, Childs SJ, Gerull B. Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. Transl Res. 2019 Jun;208:15-29. Epub 2019 Feb 15.PMID: 30802431 

Bahrami N, Childs SJ. Pericyte Biology in Zebrafish. Adv Exp Med Biol. 2018;1109:33-51. PMID: 30523588 Review.

Gomez-Garcia MJ , Doiron AL , Steele RRM , Labouta HI , Vafadar B , Shepherd RD , Gates ID , Cramb DT, Childs SJ , Rinker KD. Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology. Nanoscale. 2018 Aug 16;10(32):15249-15261. PMID: 30066709

Jiang XY, Sarsons CD, Gomez-Garcia MJ, Cramb DT, Rinker KD, Childs SJ. Quantum dot interactions and flow effects in angiogenic zebrafish (Danio rerio) vessels and human endothelial cells. Nanomedicine. 2017 Apr;13(3):999-1010. Epub 2016 Dec 18.PMID: 27993727

Lamont RE, Wu CY, Ryu JR, Vu W, Davari P, Sobering RE, Kennedy RM, Munsie NM, Childs SJ. The LIM-homeodomain transcription factor Islet2a promotes angioblast migration. Dev Biol. 2016 Jun 15;414(2):181-92. Epub 2016 Apr 25.PMID: 27126199 

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC). Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 2016 Jun;15(7):695-707. Epub 2016 Apr 7.PMID: 27068588 

Goi M, Childs SJ. Patterning mechanisms of the sub-intestinal venous plexus in zebrafish.

Dev Biol. 2016 Jan 1;409(1):114-128. Epub 2015 Oct 22.PMID: 26477558.

Tamplin OJ, Durand EM, Carr LA, Childs SJ, Hagedorn EJ, Li P, Yzaguirre AD, Speck NA, Zon LI. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15;160(1-2):241-52. PMID: 25594182.

Arnold CR, Lamont RE, Walker JT, Spice PJ, Chan CK, Ho CY, Childs SJ. Comparative analysis of genes regulated by Dzip1/iguana and hedgehog in zebrafish. Dev Dyn. 2015 Feb;244(2):211-23. Epub 2015 Jan 8.PMID: 25476803

French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, Waskiewicz AJ, Lehmann OJ. Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J Clin Invest. 2014 Nov;124(11):4877-81. Epub 2014 Sep 24.PMID: 25250569 

Ebert AM, Childs SJ, Hehr CL, Cechmanek PB, McFarlane S. Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development. 2014 Jun;141(12):2473-82. PMID: 24917502

Whitesell TR, Kennedy RM, Carter AD, Rollins EL, Georgijevic S, Santoro MM, Childs SJ.  An α-smooth muscle actin (acta2/αsma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 2014 Mar 3;9(3):e90590. eCollection 2014.PMID: 24594685 Free PMC article.

Zeng L, Childs SJ. The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Dev Biol. 2012 Jul 15;367(2):178-86. Epub 2012 May 16.PMID: 22609551

Liu J, Zeng L, Kennedy RM, Gruenig NM, Childs SJ. βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8. Dev Biol. 2012 Mar 1;363(1):95-105. Epub 2011 Dec 22.PMID: 22206757

Chik JK, Schriemer DC, Childs SJ, McGhee JD. Proteome of the Caenorhabditis elegans oocyte. J Proteome Res. 2011 May 6;10(5):2300-5. Epub 2011 Apr 15.PMID: 21452892

Zuccolo J, Bau J, Childs SJ, Goss GG, Sensen CW, Deans JP. Phylogenetic analysis of the MS4A and TMEM176 gene families. PLoS One. 2010 Feb 23;5(2):e9369. PMID: 20186339 

Lamont RE, Vu W, Carter AD, Serluca FC, MacRae CA, Childs SJ. Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mech Dev. 2010 Apr;127(3-4):159-68. Epub 2010 Feb 13.PMID: 20156556

Christie TL, Carter A, Rollins EL, Childs SJ. Syk and Zap-70 function redundantly to promote angioblast migration. Dev Biol. 2010 Apr 1;340(1):22-9. 2010 Jan 22.PMID: 20096681

Zeng L, Carter AD, Childs SJ. miR-145 directs intestinal maturation in zebrafish. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17793-8. Epub 2009 Oct 5.PMID: 19805048 

Lamont RE, Lamont EJ, Childs SJ. Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Dev Biol. 2009 Jul 15;331(2):199-209.

Callander DC, Lamont RE, Childs SJ, McFarlane S. Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons. Dev Dyn. 2007 Oct;236(10):2918-24.

Liu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, Childs SJ. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13990-5. Epub 2007 Jun 15.PMID: 17573532 

Georgijevic S, Subramanian Y, Rollins EL, Starovic-Subota O, Tang AC, Childs SJ.  Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Dev Dyn. 2007 Jun;236(6):1623-32.