Chen Lab
Chen Lab
ACT with Biomaterials
ACT with Biomaterials
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Our Research
Our Research
We are dedicated to materials science and engineering-based new technologies and treatments to improve health. Our research is highly interdisciplinary and transdisciplinary, involving materials science, chemistry, biology, medical imaging, and life sciences. We welcome collaborations on projects broadly related to human health, biomedical imaging, and biomaterials.
Our current research focuses on ophthalmic biomedical engineering. We use nanoscale and macroscale biomaterials to tackle unmet clinical needs in the eye's anterior and posterior segments. Our research directions include advancing cell therapies in the eye with biomaterials, corneal wound healing, sustained drug delivery, the synthesis mechanism of nanoparticles and their interaction with cells, etc.
Advancing Cell Therapies
Advancing Cell Therapies
Related reading:
Gold nanoparticles to enhance ophthalmic imaging. Biomaterials Science. 2021, 9(2), 367-390.
Increasing the efficacy of stem cell therapy via triple-function inorganic nanoparticles. ACS Nano. 2019, 13(6), 6605-6617.
Exosome-like silica nanoparticles: a novel ultrasound contrast agent for stem cell imaging. Nanoscale. 2017, 9(1), 402-411.
Photoacoustic imaging of human mesenchymal stem cells labeled with prussian blue-poly (l-lysine) nanocomplexes. ACS nano. 2017, 11(9), 9022-9032.
Biomaterials. 2020, 255, 120176.
Corneal Wound Healing
Corneal Wound Healing
Related reading:
In situ-forming semi-interpenetrating polymer network (SIPN) hydrogel of crosslinked collagen and hyaluronic acid enhances corneal defect repair. Translational Vision Science & Technology. 2022, 11(10), 22.
Bio-orthogonally crosslinked, in situ-forming collagen-hyaluronate co-polymer for suture-free corneal defect repair. Biomaterials. 2020, 255, 120176.
Simultaneous interpenetrating polymer network of collagen and hyaluronic acid as an in situ-forming corneal defect filler. Chemistry of Materials. 2020, 32(12), 5208-5216.
Naunyn-Schmiedeberg's Archives of Pharmacology, 2022, 1-31.
Sustained Drug Delivery in the Eye
Sustained Drug Delivery in the Eye
Related reading:
Nanomedicine and drug delivery to the retina: current status and implications for gene therapy. Naunyn-Schmiedeberg's Archives of Pharmacology, 2022, 1-31.
Photoacoustic imaging quantifies drug release from nanocarriers via redox chemistry of dye-labeled cargo. Angew. Chem. Int. Ed. 2020, 59, 4678-4683.
RSC Advances. 2021, 11 (57), 35796-35805.
Nanoparticle and Cell Interaction
Nanoparticle and Cell Interaction
Related reading:
Quantifying Particle Concentration Via AI-enhanced Optical Coherence Tomography. Nanoscale 2024, 16 (14), 6934-6938.
Fusogenic Liposome-Enhanced Cytosolic Delivery of Magnetic Nanoparticles. RSC Advances. 2021, 11 (57), 35796-35805.
Gold nanoparticles to enhance ophthalmic imaging. Biomaterials Science. 2021, 9(2), 367-390.
Cellular toxicity of silicon carbide nanomaterials as a function of morphology. Biomaterials. 2018, 179, 60-70.
Current Eye Research. 2021, 1-10.
Surgical Tool Innovation
Surgical Tool Innovation
Related reading:
Development of Simple Inner-Stopper Guarded Trephine to Create Consistent Keratectomy Wounds in Rodents. Journal of Ophthalmic and Vision Research, 2021, 16(4), 544.
3D Printable, Modified Trephine Designs for Consistent Anterior Lamellar Keratectomy Wounds in Rabbits. Current Eye Research. 2021, 1-10.
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