Chelsey Doyle, Breedge Conwell, Megan Henry, Katarzyna Goljanek-Whysall, David Simpson, Carl Sheridan, Colin E Willoughby. The TGFβ2 induced microRNAome of the trabecular meshwork. ARVO 2021 (Oral Presentation). Travel Award Received.
Breedge Conwell, Chelsey Doyle, Anton Roodnat, Megan Henry, Katarzyna Goljanek-Whysall, Sarah D. Atkinson, David Simpson, Colin E Willoughby. TGFβ1 regulated gene expression in the trabecular meshwork. ARVO 2021 (Poster Presentation).
Chelsey Doyle, Breedge Conwell, Katarzyna Goljanek-Whysall, David Simpson, Carl Sheridan, Colin E Willoughby. MicroRNA based therapeutics for fibrosis in primary open angle glaucoma and pseudoexfoliation glaucoma. World Glaucoma Congress 2021 (Oral Presentation). Travel Award Received.
Chelsey Doyle, John Knox, Breedge Conwell, Kevin Hamill, Colin E Willoughby. MiR-17-92 cluster induction by TGFb2 in human trabecular meshwork cells identifies miR-18a as a potential therapeutic target. ISER/BrightFocus 2022. Atlanta USA. (Poster Presentation). Travel Award Received.
I have four publications in preparation in relation to TGFβ, microRNAs, gene expression and the trabecular meshwork in glaucoma.
Three of these research papers are in the writing stages and one is currently being reviewed.
Doyle C, Callaghan B, Roodnat AW, Armstrong L, Lester K, Simpson DA, Atkinson SD, Sheridan C, McKenna DJ, Willoughby CE. The TGFβ Induced MicroRNAome of the Trabecular Meshwork. Cells. 2024 Jun 19;13(12):1060. doi: 10.3390/cells13121060. PMID: 38920689; PMCID: PMC11201560.
Roodnat AW, Doyle C, Callaghan B, Lester K, Henry M, Sheridan C, McKenna DJ, Willoughby CE, Atkinson SD. Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. PLoS One. 2025 Jan 30;20(1):e0318125. doi: 10.1371/journal.pone.0318125. PMID: 39883689; PMCID: PMC11781692.
Roodnat AW, Callaghan B, Doyle C, Vallabh NA, Atkinson SD, Willoughby CE. Genome-wide RNA sequencing of ocular fibroblasts from glaucomatous and normal eyes: Implications for glaucoma management. PLoS One. 2024 Jul 11;19(7):e0307227. doi: 10.1371/journal.pone.0307227. PMID: 38990974; PMCID: PMC11239048.
Roodnat AW, Callaghan B, Doyle C, Henry M, Goljanek-Whysall K, Simpson DA, Sheridan C, Atkinson SD, Willoughby CE. Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation Glaucoma. Biomolecules. 2022 Nov 15;12(11):1693. doi: 10.3390/biom12111693. PMID: 36421707; PMCID: PMC9687758.
Coyle S, Khan MN, Chemaly M, Callaghan B, Doyle C, Willoughby CE, Atkinson SD, Gregory-Ksander M, McGilligan V. Targeting the NLRP3 Inflammasome in Glaucoma. Biomolecules. 2021 Aug 19;11(8):1239. doi: 10.3390/biom11081239. PMID: 34439904; PMCID: PMC8393362.
Chelsey Doyle, Breedge Callaghan, Colin E Willoughby; MicroRNA regulation of fibrosis in the trabecular meshwork. Glaucoma Research and Clinical Advances. Kugler Publications (2024).
Chelsey Doyle, Breedge Conwell, Megan Henry, Katarzyna Goljanek-Whysall, David Simpson, Carl Sheridan, Colin E Willoughby; The TGFβ2 induced microRNAome of the trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1654.
Breedge Conwell, Chelsey Doyle, Anton Roodnat, Megan Henry, Katarzyna Goljanek-Whysall, Sarah D. Atkinson, David Simpson, Colin E Willoughby; TGFβ1 regulated gene expression in the trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1634.