Coupling of Phase equilibria to reaction Equilibria
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Recent discoveries of phase separation of biomacromolecules to compartmentalize the intracellular environment have upended the traditional understanding of cellular compartmentalization mediated by membranes. The goal of lab’s research will be to understand how phase separation affects different classes of biochemical reactions and to uncover physicochemical principles that lead to acceleration vs. attenuation of reactions.
Computational Enzyme Engineering
Enzymes are often used as biocatalysts in a variety of industrial applications, such as the production of biofuels. Molecular modeling can elucidate mechanisms behind the catalytic properties of enzymes and guide the rational design of enzymes. My research group will use molecular modeling combined with coarse-grained simulations to study how enzymes can be engineered to optimize the production of biofuels and desired value-added products. This includes investigating how we can creatively use the emerging concept of phase separation of proteins to design highly efficient biocatalysts.
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