Skin cancer effects around 3.5 million people each year and it is caused by the exposure to ultraviolet light. This exposure damages the skin's DNA causing a mutation, that stops the cell from controlling its growth. One defense mechanism our body already has to this problem is antioxidant enzymes. These enzymes work to stabilize and deactivate the free radicals before they attack our cells. (Krishnamurthy, 2012) Three enzymes of interest known as methionine sulfoxide reductase A (MSRA), superoxide dismutase 1 and glutathione peroxidase 2 were picked due to their specific abilities to work as an antioxidant and protect from the ultraviolet light damage. The reason that these enzymes don’t currently protect from UV radiation is because they aren’t commonly found in our skin. Although there are small traces, it isn’t enough to prevent the breakdown of cells. To enhance the three enzymes, we found the primers that are directly related to activating the enzymes and also the off-target regions where the enzymes can be found. The Crispr process will be used to enhance higher concentrations of the primers. The Crispr method works by having off-target locations carry the protein and knock-in or insert our primers into the designated region that are associated with the skin. To find out which of the off-target regions are associated regions, the 300 potential regions where taken along with the known database of all skin genome research and a program was made to cross-check and find the regions of association.