9. Choi, Y., Cho, S., Gu, C., Kim, C., Park, B., and Kim, H., “Liver cancer risk stratification using deep learning on nationwide longitudinal health screening data: a retrospective cohort study”, BMC Med. Inform. Decis. Mak., accepted (2026)
8. Jang, W.D.*, Gu, C.*, Noh, Y., Oh, K.S., and Ryu, J.Y., “ChemBounce: a computational framework for scaffold hopping in drug discovery”, Bioinformatics, 41(9), btaf501 (2025) Link / GitHub
7. Park, Y.*, Lim, S.*, Gu, C.*, Syafiandini, A. F., and Song, M., “Forecasting topic trends of blockchain utilizing topic modeling and deep learning-based time-series prediction on different document types”, J. Informetr., 19(2): 101639 (2025) Link
6. Gu, C., Jang, W.D., Oh, K.S., and Ryu, J.Y., “AnoChem: Prediction of chemical structural abnormalities based on machine learning models”, Comput. Struct. Biotechnol. J., 23: 2116-2121 (2024) Link / GitHub
5. Gu, C.*, Park, S.*, Seok, J., Jang, H.Y., Bang, Y.J., and Kim, G.J., “Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression”, Biol. Reprod., 104(1): 159-169 (2021) Link
4. Kim, Y., Gu, C., Kim, H.U., and Lee, S.Y., "Current status of pan-genome analysis for pathogenic bacteria", Curr. Opin. Biotechnol., 63: 54-62 (2020) Link
3. Yang, D., Yoo, S.M., Gu, C., Ryu, J.Y., Lee, J.E., and Lee, S.Y., "Expanded synthetic small regulatory RNA expression platforms for rapid and multiplex gene expression knockdown", Metab. Eng., 54: 180-190 (2019) Link
2. Gu, C.*, Kim, G.B.*, Kim, W.J., Kim, H.U., and Lee, S.Y., "Current status and applications of genome-scale metabolic models", Genome Biol., 20: 121. (2019) Link
1. Cho, J.S., Gu, C., Han, T.H., Ryu, J.Y., and Lee, S.Y., "Reconstruction of context-specific genome-scale metabolic models using multiomics data to study metabolic rewiring", Curr. Opin. Sys. Biol., 15: 1-11 (2019) Link
* equal contribution
1. 구창대, 박노성, "인공지능 기반의 국내외 신약 개발 및 연구 동향", 한국정보과학회지, 40(3): 8-21
Gu, C., Park, N., "Global trend of artificial intelligence-based drug development and related researches", Communications of the Korean Institute of Information Scientists and Engineers, 40(3): 8-21 Link
* equal contribution
“METHOD FOR ESTIMATING TISSUE LEVEL INFORMATION FROM CELL LEVEL INFORMATION AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Gu, C.,
- International Application (PCT) PCT/KR2022/002842 (2022.02.28), Published WO 2022/196971 A1 (2022.09.22)
“METHOD FOR PREDICTING COMBINATION INFORMATION OF DRUG AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C.,
- Korean Patent appl. 10-2021-0074817 (2021.04.12), PRI 10-2021-0046893 (2021.06.09), Registered 10-2454641 (2022.10.11)
- International Application (PCT) PCT/KR2022/005089 (2022.04.08), Published WO 2022/220493 (2022.10.20)
“APPARATUS FOR TRANSFORMING BIOLOGICAL STATE DATA BASED ON NEURAL NETWORK AND METHOD THEREOF”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C.,
- International Application (PCT) PCT/KR2022/005094 (2022.04.08), Published WO 2022/220496 (2022.10.20)
“APPARATUS FOR PREDICTING DRUG EFFECT AND METHOD THEREOF”, Gu, C., Lee, Y. H., Sim, W., Kim, Y. R.,
- International Application (PCT) PCT/KR2022/005096 (2022.04.08), Published WO 2022/231165 (2022.11.03)
“METHOD FOR PREDICTING RELATIONSHIP BETWEEN GENE AND TRANSCRIPTION FACTOR AND APPARATUS THEREOF”, Gu, C., Kim, Y. R.,
- International Application (PCT) PCT/KR2022/008305 (2022.06.13), Published WO 2022/265323 (2022.12.22)
“METHOD FOR PROGNOSIS OF GASTRIC CANCER USING ARTIFICIAL INTELLIGENCE”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169874 (2020.12.07), Registered 10-2246584 (2021.04.28)
“METHOD FOR PROGNOSIS OF BREAST CANCER USING RIBOSOMAL PROTEIN FROM ARTIFICIAL INTELLIGENCE”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169943 (2020.12.07), Registered 10-2271315 (2021.06.24)
“METHOD FOR PROGNOSIS OF BREAST CANCER USING MITOCHONDRIA RIBOSOMAL PROTEIN ARTIFICIAL INTELLIGENCE”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169949 (2020.12.07), Registered 10-2271313 (2021.06.24)
“METHOD FOR PROGNOSIS OF BREAST CANCER USING GENE SET FROM ARTIFICIAL INTELLIGENCE”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169518 (2020.12.07), Registered 10-2293109 (2021.08.18)
“METHOD OF PREDICTION OF BREAST CANCER USING AI”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169517 (2020.12.07), Registered 10-2293110 (2021.08.18)
“METHOD FOR PREDICTING PROGNOSIS BASED ON MACHINE-LEARNING AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C., Jo, J.,
- Korean Patent appl. 10-2020-0169694 (2020.12.07), Registered 10-2299221 (2021.09.01)
“METHOD FOR ESTIMATING TISSUE LEVEL INFORMATION FROM CELL LEVEL INFORMATION AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Gu, C.,
- Korean Patent appl. 10-2021-0035107 (2021.03.18), PRI 10-2021-0074816 (2021.06.09), Registered 10-2462784 (2022.10.31)
“METHOD FOR PREDICTING COMBINATION INFORMATION OF DRUG AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C.,
- Korean Patent appl. 10-2021-0074817 (2021.04.12), PRI 10-2021-0046893 (2021.06.09), Registered 10-2454641 (2022.10.11)
“APPARATUS FOR TRANSFORMING BIOLOGICAL STATE DATA BASED ON NEURAL NETWORK AND METHOD THEREOF”, Kim, Y. R., Lee, Y. H., Sim, W., Gu, C.,
- Korean Patent appl. 10-2021-0050059 (2021.04.16), Registered 10-2487364 (2023.01.06)
“APPARATUS FOR PREDICTING DRUG EFFECT AND METHOD THEREOF”, Gu, C., Lee, Y. H., Sim, W., Kim, Y. R.,
- Korean Patent appl. 10-2021-0053636 (2021.04.26), Registered 10-2554305 (2023.07.06)
“METHOD FOR PREDICTING RELATIONSHIP BETWEEN GENE AND TRANSCRIPTION FACTOR AND APPARATUS THEREOF”, Gu, C., Kim, Y. R.,
- Korean Patent appl. 10-2021-0077359 (2021.06.15)
“METHOD FOR ESTIMATING TISSUE LEVEL INFORMATION FROM CELL LEVEL INFORMATION AND APPARATUS THEREOF”, Kim, Y. R., Lee, Y. H., Gu, C.,
- US Patent appl. (2022.10.14)
Gu, C., Choi, J. H., Seok, J., Jang, H. Y., Park, J. W., Bhang, J. Y., and Kim, G. J., “Alteration of ADM/ADM2 by hypoxia regulates migration and immunomodulation of trophoblast”, American Society for Cell Biology(ASCB) 2016 annual meeting, American Society for Cell Biology (ASCB), Moscone Center, San Francisco, CA, USA, 3-7 Dec. 2016
Gu, C., Ryu, J. Y., Kim, H. U., and Lee, S. Y., “An automatic platform for reconstruction and comparative analysis of genome-scale metabolic models of microbial community”, The 30th International Symposium on Chemical Engineering (ISChE 2017), The Korea Institute of Chemical Engineers (KIChE), Daejeon, Korea, 1-3 Dec. 2017
Ryu, J. Y., Kim, H. U., Gu, C., and Lee, S. Y., “Prediction of drug-drug and drug-food interactions using deep learning method”, Metabolic Engineering Summit 2019 (MES 2019), American Institute of Chemical Engineers (AIChE), Tianjin, China, 20-22 Oct. 2019
Chae, T. U., Choi, S. Y., Ryu, J. Y., Gu, C., and Lee, S. Y., “Metabolic engineering of Escherichia coli for production of ethylene glycol from xylose”, Metabolic Engineering Summit 2019 (MES 2019), American Institute of Chemical Engineers (AIChE), Tianjin, China, 20-22 Oct. 2019
Ryu, J. Y., Kim, H. U., Gu, C., and Lee, S. Y., “Development of framework for human metabolic gene-transcript-protein-reaction associations”, Metabolic Engineering Summit 2019 (MES 2019), American Institute of Chemical Engineers (AIChE), Tianjin, China, 20-22 Oct. 2019
Gu, C., Jang, W. D., Noh, Y., Oh, K., and Ryu, J. Y., “A computational scaffold hopping platform with anomaly detection for early drug discovery process”, Global Young Scientists Summit (GYSS) 2026, National Research Foundation Singapore, Stephen Riady Centre, National University of Singapore, Singapore, 5-9 Jan. 2026
Gu, C., Kim, D. I., and Lee, S. Y., “Platform for the design of novel biosynthetic pathways to produce industrially valuable chemicals”, 2017 KIChE Fall Meeting and International Symposium, The Korean Institute of Chemical Engineers, DCC, Daejeon, 25-27 Oct. 2017.
Gu, C., Cho, J. S., Kim, S. Y., Lee, J. M., and Lee, S. Y., “L-ornithine production in Corynebacterium glutamicum through metabolic engineering”, 2017 KIChE Fall Meeting and International Symposium, The Korean Institute of Chemical Engineers, DCC, Daejeon, 25-27 Oct. 2017.
Gu, C., Choi, Y. J., and Lee, S. Y., “Metabolic engineering of Escherichia coli for short chain alkanes production through novel pathway”, 2018 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, Ceco, Chnagwon, Korea, 25-27 Apr. 2018.
Gu, C., Yang, J. E., Kim, J. W., Choi, S. Y., Lee, S. Y., Oh, Y. H., Lee, H., Oh., A. R., Sin, J. H., and Park, S. J., “Poly(2-hydroxyisovalerate-co-lactate) production in Escherichia coli by metabolic engineering method”, 2018 KIChE Spring Meeting and International Symposium, The Korean Institute of Chemical Engineers, Ceco, Chnagwon, Korea, 25-27 Apr. 2018.
Gu, C., Ryu, J. Y., Kim, H. U., and Lee, S. Y., “A Framework for 11,000+ Gene-Transcript-Protein-Reaction Associations (GeTPRA) in Human Metabolism and Integrated Resources”, 2018 KSBB International Academia-Indestry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 Oct. 2018.
Gu, C., Ryu, J. Y., Hur, W., Kim, H. U., Hong, S. W., Lee, E. B., Lee, S. Y., and Yoon, S. K., “Characterization of Metabolism in Liver Cancer Stem Cell Using Systems Biologic Methods”, 2018 KSBB International Academia-Indestry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 Oct. 2018.
Gu, C., Choi, Y. J., and Lee, S. Y., “Metabolic Engineering of Escherichia coli for Production of Short Chain Alkanes through a Novel Pathway”, 2018 KSBB International Academia-Indestry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 Oct. 2018.
Gu, C., Ryu, J. Y., Kim, H. U., and Lee, S. Y., “Prediction of Drug-Drug and Drug-Food Interactions Using Deep Learning Methods”, 2018 KSBB International Academia-Indestry Joint Meeting, The Korean Society for Biotechnology and Bioengineering, Sejong University Convention Center, Seoul, 10-12 October 2018
Gu, C., Choi, K. R., Zhao, X. R., and Lee, S. Y., “Production of Extracellular Free Heme in Escherichia coli Using Metabolic Engineering Methods”, 46th Annual Meeting & International Symposium, The Korean Society for Microbiology and Biotechnology, ICC Jeju, Jeju, Korea, 23-25 June 2019
Gu, C., Park, S. Y., Binkley, R. M., Kim, W. J., Lee, M. H., and Lee, S. Y., “Production of High-Level Astaxanthin in Escherichia coli Using Metabolic Engineering Methods”, 46th Annual Meeting & International Symposium, The Korean Society for Microbiology and Biotechnology, ICC Jeju, Jeju, Korea, 23-25 June 2019
Gu, C., Yang, D., Yoo, S. M., Ryu, J. Y., Lee, J. E., and Lee, S. Y., “Development of Rapid and Multiplex Metabolic Engineering Platform Using Expanded sRNA Expression System in Escherichia coli”, 46th Annual Meeting & International Symposium, The Korean Society for Microbiology and Biotechnology, ICC Jeju, Jeju, Korea, 23-25 June 2019
Ryu, J. Y., Gu, C., Kim, H. U., and Lee, S. Y., “DeepEC: a Computational Framework for Prediction of Enzyme Commission Numbers Using Deep Learning Method”, 2019 KSBB Fall Meeting and International Symposium, The Korean Society for Biotechnology and Bioengineering, EXCO, Daegu, Korea, 9-11 October 2019
Ryu, J. Y., Kim, H. U., Gu, C., and Lee, S. Y., “A Deep Learning Method for Prediction of Drug-Drug and Drug-Food Interactions”, 2019 KSBB Fall Meeting and International Symposium, The Korean Society for Biotechnology and Bioengineering, EXCO, Daegu, Korea, 9-11 October 2019
Yang, D. S., Yoo, S. M., Gu, C., Ryu, J. Y., Lee, J. E., and Lee, S. Y., “Development of Rapid and Multiplex Knockdown Platform in Escherichia coli Using Expanded Synthetic sRNA Expression System”, 2019 KSBB Fall Meeting and International Symposium, The Korean Society for Biotechnology and Bioengineering, EXCO, Daegu, Korea, 9-11 October 2019
Ryu, J. Y., Hur, W., Kim, H. U., Hong, S. W., Lee, E. B., Gu, C., Lee, S. Y., and Yoon, S. K., “Systematic Characterization of Liver Cancer Stem Cells”, 2019 KSBB Fall Meeting and International Symposium, The Korean Society for Biotechnology and Bioengineering, EXCO, Daegu, Korea, 9-11 October 2019
Gu, C., Jang, W. D., Oh, K., Kang, J., Jeong, Y. U., and Ryu, J. Y., “Machine Learning-based Anomaly Detection for Generated Chemical Structures”, 2023 KSBB Fall Meeting and International Symposium, The Korean Society for Biotechnology and Bioengineering, BEXCO, Busan, Korea, 4-6 October 2023
Gu, C., Jang W. D.,Oh K., and Ryu J. Y., “Detection of chemical structural anomaly using machine learning method”, 2025 Yonsei HTAN SCL G1’s Lab K-BioX Global Summit 6, Severance, Seoul, Korea, 2 May 2025