楊閎蔚

基本資料

姓名：
楊閎蔚

電子信箱：
howardyang@gs.ncku.edu.tw

連絡電話/傳真：
TEL: 06-2757575#63421

服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
國立成功大學

生物醫學工程學系

教授

機構地址：
701台南市東區大學路1號

個人網站：

https://sites.google.com/site/labofnba/

研究領域：
Biopolymer and hydrogel synthesis

NanoBiomaterials design & synthesis

Virus-like particles delivery system

Drug, DNA, RNAi, vaccine delivery

Cell therapy and immunotherapy

Microneedles for intradermal drug/vaccine delivery

Smart biosensing system

個人簡歷

Dr. Hung-Wei Yang obtained his Ph.D. degree from Chang Gung University in Taiwan. He then worked as postdoctoral research fellow in Department of Chemical Engineering, National Tsing Hua University in Taiwan (2011/08~2013/02) and School of Chemical & Biomolecular Engineering, Georgia Institute of Technology in USA (2013/03~2014/07). He joined the faculty of the Institute of Medical Science and Technology, National Sun Yat-sen University in 2014/08 and became an Associate Professor in 2018/02. His research interests are NanoBiomaterials for drug/gene delivery, virus-like particles-based cancer vaccine and gene therapy, microneedles-based intradermal drug/vaccine delivery system, and biosensor integrated with smartphone for medical use and personal healthcare.

發表論文或著作等

Selected Publications (2017~2020):

1. H.H. Pang, Y.C. Ke, N.S. Li, Y.T. Chen, C.Y. Huang, K.C. Wei*, H.W. Yang*. A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to predict drug-resistance level. Biosensors and Bioelectronics 165, 112325 (2020).

2. N.S. Li, Y.T. Chen, Y.P. Hsu, H.H. Pang, C.Y. Huang, Y.L. Shiue, K.C. Wei*, H.W. Yang*. Mobile healthcare system based on the combination of lateral flow pad and smartphone for rapid detection of uric acid detection in whole blood. Biosensors and Bioelectronics 164, 112309 (2020).

3. W.L. Hsu, C.Y. Huang, Y.P. Hsu, T.L. Hwang, S.H. Chang, H.Y.J. Wang, L.Y. Feng, S.J. Tzou, K.C. Wei*, H.W. Yang*. On-skin glucose-biosensing and hyperglycaemia-triggered insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management. Chemical Engineering Journal 398, 125536 (2020).

4. Y.P. Hsu, N.S. Li, Y.T. Chen, H.H. Pang, K.C. Wei, H.W. Yang*. A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone. Biosensors and Bioelectronics 151, 111960 (2020).

5. Y.P. Hsu, H.W. Yang*, N.S. Li, Y.T. Chen, H.H. Pang, S.T. Pang*. A urological point-of-care FXYD3 test for early urothelial carcinoma screening and postoperative monitoring. ACS Sensors 5, 928-935 (2020).

6. N.S. Li#, W.L. Lin#, Y.P. Hsu, Y.T. Chen, Y.L. Shiue, H.W. Yang*. Combined Detection of CA19-9 and MUC1 Using a Colorimetric Immunosensor Based on Magnetic Gold Nanorods for Ultrasensitive Risk Assessment of Pancreatic Cancer. ACS Applied Bio Materials 2, 4847-4855 (2019).

7. H.W. Yang, S.P. Ju*, H.Y. Chen, Y.C. Cheng, W.L. Hsu. Ovalbumin-loaded gelation microneedles made of predictive formulation by molecular dynamics simulation for enhancement of skin immunization. ACS Biomaterials Science & Engineering 5, 6012-6021 (2019).

8. H.W. Yang, S.P. Ju*, Y.S. Lin. Predicting the most stable aptamer/target molecule complex configuration using a stochastic-tunnelling basin-hopping discrete molecular dynamics method. Computational and Structural Biotechnology Journal 17, 812-820 (2019).

9. H.H. Pang#, C.Y. Huang#, Y.W. Chou, C.J. Lin, Z.L. Zhou, Y.L. Shiue, K.C. Wei*, H.W. Yang*. Bioengineering fluorescent virus-like particle/RNAi nanocomplexes act synergistically with temozolomide to eradicate brain tumors. Nanoscale, 11, 8102-8109 (2019).

10. P.C. Lee#, N.S. Li#, Y.P. Hsu, C. Peng, H.W. Yang*. Direct glucose detection in whole blood by colorimetric assay based on glucose oxidase-conjugated graphene oxide/MnO2 nanozymes. Analyst 144, 3038-3044 (2019).

11. H.H. Pang#, P.Y. Chen#, K.C. Wei, C.W. Huang, Y.L. Shiue, C.Y. Huang*, H.W. Yang*. Convection-enhanced delivery of a virus-like nanotherapeutic agent with dual-modal imaging for besiegement and eradication of brain tumors. Theranostics 9, 1752-1763 (2019). [Inside Front Cover]

12. C. Peng#, M.Y. Hua#, N.S. Li, Y.P. Hsu, Y.T. Chen, C.K. Chuang, S.T. Pang*, H.W. Yang*. A colorimetric immunosensor based on self-linkable dual-nanozyme for ultrasensitive bladder cancer diagnosis and prognosis monitoring. Biosensors and Bioelectronics 126, 581-589 (2019).

13. H.W. Yang, S.P. Ju*, C.H. Cheng, Y.T. Chen, Y.S. Lin, S.T. Pang. Aptasensor designed via the stochastic tunneling-basin hopping method for biosensing of vascular endothelial growth factor. Biosensors and Bioelectronics 119, 25-33 (2018).

14. T.Y. Lin, K.C. Wei, S.P. Ju, C.Y. Huang, H.W. Yang*, Diagnosis by simplicity: An aptachip for dopamine capture and accurate detection with a dual colorimetric and fluorometric system. Journal of Materials Chemistry B 6, 3387-3394 (2018).

15. L.H. Pan, S.T. Pang, P.Y. Fang, C.K. Chuang, H.W. Yang*, Label-free biochips for accurate detection of Prostate Cancer in clinic: Dual biomarkers and circulating tumor cells. Theranostics 7, 4289-4300 (2017).

16. F.W. Lin, P.Y. Chen, K.C. Wei, C.Y. Huang, C.K. Wang, H.W. Yang*, Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor. Theranostics 7, 2524-2536 (2017).

17. J.F. Liao, J.C. Lee, C.K. Lin, K.C. Wei, P.Y. Chen, H.W. Yang*, Self-assembly DNA polyplex vaccine inside dissolving microneedles for high-potency intradermal vaccination. Theranostics 7, 2593-2605 (2017). [Front Cover]

18. S.T. Pang, F.W. Lin, C.K. Chung, H.W. Yang*. Co-delivery of docetaxel and p44/42 MAPK siRNA using PSMA antibody-conjugate BSA-PEI layer-by-layer nanoparticles for prostate cancer target therapy. Macromolecular Bioscience 17, 1600421 (2017).

19. P.Y. Fang, L.M.G. Ramos, S. Holguín, C. Hsiao, J.C. Bowman, H.W. Yang*, L.D. Williams*. Functional RNAs: Combined Assembly and Packaging in VLPs. Nucleic Acids Research 45, 3519-3527 (2017).

20. H.W. Yang, L. Ye, X. Guo, C. Yang, R.W. Compans, M.R. Prausnitz*. Ebola vaccination using a DNA vaccine coated on PLGA-PLL/γPGA nanoparticles administered using a microneedle patch to improve vaccine stability and immunogenicity. Advanced Healthcare Materials 6, 1600750 (2017).

21. L.H. Pan, T.Y. Lin, S.H. Kuo, C.W. Lin, P.Y. Fang, H.W. Yang*. An electrochemical biosensor to detect VEGF and PSA simultaneously for early prostate cancer diagnosis based on graphene oxide/ssDNA/polymer nanoparticles. Biosensors & Bioelectronics 89, 598-605 (2017).

專利

完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)

Education:

2011-Ph.D., Chemical and Materials Engineering, Chang Gung University, Taiwan.

2006-M.S., Chemical and Materials Engineering, Chang Gung University, Taiwan.

Professional Experience:

2018/08~-Associate Professor, Institute of Medical Science & Technology, NSYSU, Taiwan 

2014/08~2018/07-Assistant Professor, Institute of Medical Science & Technology, NSYSU, Taiwan 

2013/04~2014/07-NIH Postdoctoral Fellow, Georgia Institute of Technology, USA  

2011/08~2013/03-Postdoctoral Fellow, National Tsing Hua University, Taiwan  

Honor and Award:

2020   Outstanding Paper Award, Association of Chemical Sensors in Taiwan

2019   108 臺綜大年輕學者創新研究成果選拔 優等獎

2019   Distinguished Young Scholar Award, National Sun Yat-sen University, Taiwan (2019~2022)

2019   Excellent Academic Research Award, National Sun Yat-sen University

2019   Outstanding Paper Award, Association of Chemical Sensors in Taiwan

2018   Excellent Academic Research Award, National Sun Yat-sen University

2017  Project for Excellent Junior Research Investigators, Ministry of Science and Technology (2017~2021)

2017  Project for Excellent Junior Research Investigators, Ministry of Science and Technology (2017~2020)

2017   Outstanding Paper Award, Association of Chemical Sensors in Taiwan

2016   105 臺綜大年輕學者創新研究成果選拔 佳作獎

2016   13th National Innovation Award, Taiwan

2015   New Faculty Recruitment Award, National Sun Yat-sen University, Taiwan

2014   New Faculty Recruitment Award, National Sun Yat-sen University, Taiwan

2013   The Best Poster Award, 2nd Nanomedicine for Imaging and Treatment Conference, Los Angeles USA

2010   The Best Poster Award, The 10th Asian Congress of Urology of the Urological Association of Asia

Professional Activity (reviewer):

Advanced Materials

Advanced Functional Materials

Advanced Science

Small

ACS Nano

ACS Applied Materials & Interfaces

ACS Sensors

Biomaterials

Journal of Controlled Release

Biosensors and Bioelectronics

Chemical Engineering Journal

Research Interests:

Biopolymer and hydrogel synthesis

NanoBiomaterials design & synthesis

Virus-like particles delivery system

Drug, DNA, RNAi, vaccine delivery

Cell therapy and immunotherapy

Microneedles for intradermal drug/vaccine delivery

Smart biosensing system