Research

Main Research Topics

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Fission yeast cells. We segmented the cells contours and their nucleus.

Cell Size Regulation

Cells grow and divide continuously in a coordinate way to keep stability in cell size and proliferation statistics. However, there is an intrinsic randomness in such processes that affects cells fitness and gene expression. We developed image processing and cell tracking pipelines for different cells including bacteria, yeast and human cells.

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C. difficile bacterial cells. We study the origin of this notably long geometry.

Gene expresion fluctuates stochasticaly over time. The gene expresion tracking a single cell (top) has different distribution than the gene expression of different individuals in a population (rigth).

Gene Expression Mechanisms

We study the origin and effects of the stochasticity in protein synthesis. This include the phenotypical diversity and the acuracy of celular timers based on the accumulation and degradation of molecules.

The time spent to accumulate certain gene products can be used to design timing mechanisms. We studied how accurate are these systems.

Cell Proliferation Dynamics

When solving the cell growth and division dynamics it is possible to predict the proliferation statistics. The inverse problem is also possible. We are studying the relationship between proliferation and cell size control statistics.

Evolutionary Dynamics

Clonal individuals can present a random phenotypes that has proven to be an evolutionay advantage in fluctuating environments. We study how to measure this evolutionary success and what are its biological implications.

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