• Ryohei Teramoto, Shiyu Ayukawa, Nagisa Kamoshita, Nobuhito Goda, Takeshi Maruyama.

　  Epithelial cells induce the polar migration via the MHC-I–AltR interaction to eliminate transformed cells.

      Bio Rxiv.2025 March .

      doi:10.1101/2025.03.01.640938

• Ayukawa S, Kamoshita N, Maruyama T.

Epithelial recognition and elimination against aberrant cells.

Seminars in immunopathology. 2024 Jan;45(4-6):521-532.

doi: 10.1007/s00281-024-01001-0. 

• Takayanagi S, Watanabe K, Maruyama T, Ogawa M, Morishita K, Soga M, Hatta T, Natsume T, Hirano T, Kagechika H, Hattori K, Naguro I, Ichijo H.

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes.

Scientific reports. 2021 Nov 10;11(1):22009. 

doi: 10.1038/s41598-021-01123-7.

• Ayukawa S., Teramoto R., Nakayama J., Kamoshita N., Pishesha N., Sato N., Kozawa K., Semba K., Goda N., Fujita Y., Maruyama T.

Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.

Nature Immunology. 2021 Nov 22;(11):1391-1402.

doi: 10.1038/s41590-021-01045-6.

• Kozawa K., Sekai M., Ohba K., Ito S., Sako H., Maruyama T., Kakeno M., Shirai T., Kuromiya K., Kamasaki T., Kohashi K., Tanaka S., Ishikawa S., Sato N., Asano S., Suzuki H., Tanimura N., Mukai Y., Gotoh N., Tanino M., Tanaka S., Natsuga K., Soga T., Nakamura T., Yabuta Y., Saitou M., Ito T., Matsuura K., Tsunoda M., Kikumori T., Iida T., Mizutani Y., Miyai Y., Kaibuchi K., Enomoto A., Fujita Y.

The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

Current Biology. 2021 Jul 26;31(14):3086-3097.e7

doi: 10.1016/j.cub.2021.04.078 

• Maruyama T. †, Sasaki A., Iijima S., Ayukawa S., Goda N., Tazuru K., Hashimoto N., Hayashi T., Kozawa K., Sato N., Ishikawa S., Morita T., Fujita Y. 

†: corresponding author 

ZAK inhibitor PLX4720 promotes Extrusion of Transformed cells via Cell Competition

     iScience. 2020 jul 24;23(7):101327. 

     doi: 10.1016/j.isci.2020.101327

• Sato N., Yako Y., Maruyama T., Ishikawa S., Kuromiya K., Tokuoka SM., Kita Y, Fujita Y.

The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia.

Communications Biology. 2020 Mar 18;3(1):132.

doi: 10.1038/s42003-020-0847-y

• Takagi M., Ikegawa M., Shimada T., Ishikawa S., Kajita M., Maruyama T., Kamasaki T., Fujita Y. 

Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cell.

Genes to cells. 2018 Nov;23(11):2097.

doi: 10.1111/gtc.12643

• Kasai N, Kadeer A, Kajita M, Saitoh S, Ishikawa S, Maruyama T†, Fujita Y† (†: corresponding author)

The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating  HDAC6-regulated tubulin  acetylation.

     Scientific reports. 2018 Feb 1; 8(1) 2097.

     doi: 10.1038/s41598-018-20146-1

• Kon S, Ishibashi K, Katoh H, Kitamoto S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Sato T, Duchen M, Shirai T, Tanaka S, Narumi R, Morita T, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y and Fujita Y

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.

Nature cell biology. 2017 May;19(5):530-541

doi: 10.1038/ncb3509

• Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Dhesycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF and Ploegh HL.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

PNAS. 2017 Mar 21;114(12):3157-3162. 

doi: 10.1073/pnas.1701746114

• Saitoh S#, Maruyama T#, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M and Fujita Y (#: equally contributed)

Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.

PNAS. 2017 Mar 21;114(12):E2327-E2336. 

doi: 10.1073/pnas.1602349114

• Kadeer A, Maruyama T, Kajita M, Morita T, Sasaki A, Ohoka A, Ishikawa S, Ikegawa M, Shimada T and Fujita Y

Plectin is a novel regulator for apical extrusion of RasV12-transformed cells.

Scientific reports, 2017 Mar 10;7:44328.

doi: 10.1038/srep44328.

• Chen GY, Li Z, Theile CS, Kumar PV, Nardhan NM, Duarte JN, Maruyama T, Grossman JC, Belcher AM and Ploegh HL

Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.

Chemistry. 2015 Nov 23;21(48):17178-83.

doi: 10.1002/chem.201503057.

• Kadowaki H, Nagai A, Maruyama T, Takami Y, Fitrah PS, Kato H, Honda A, Natsume T, Sato T, Kai H, Ichijo H and Nishitoh H

Pre-emptive Quality Conrol Protects the ER from Protein Overload via the Proximity of ERAD components and SRP.

Cell Reports. 2015 Nov 3,13 (5): 944-56

doi: 10.1016/j.celrep.2015.09.047

• Tafesse F, Rashidfarrokhi A, Frein KM, Dougan S, Schmidt F, Dougan ML, Alest BF, Maruyama T, Strijbis K and Ploegh HL

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida alblcans.

PLoS pathogens. 2015 Oct 2;11(10):e1005188. 

doi: 10.1371/journal.ppat.1005188

• Maruyama T, Dougan SK, Truttmann M, Bilate AM, Ingram J and Ploegh HL

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Nature Biotechnology. 2015 May;33(5):538-42.

doi: 10.1038/nbt.3190

• Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC and Ploegh HL

The E2 Ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice.

The Journal of biological chemistry, 2014 Dec 12;289(50):34490-502.

doi: 10.1074/jbc.M114.604132

• Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR and Ploegh HL

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

The Journal of biological chemistry, 2014 Aug 29;289(35):24005-18.  

doi: 10.1074/jbc.M114.589275

• Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL and Lodish HF.

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

PNAS. 2014 Jul 15;111(28):10131-6.

doi: 10.1073/pnas.1409861111

• Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A and Ichijo H

Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.

Science signaling. 2014 Jan 21;7(309):ra8.

doi: 10.1126/scisignal.2004822

• Sanyal S, Ashour J, Maruyama T, Altenburg AF, Cragnolini JJ, Bilate A, Avalos AM, Kundrat L, García-Sastre A and Ploegh HL

Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection.

Cell Host & Microbe, 2013 Nov 13;14(5):510-21.

doi: 10.1016/j.chom.2013.10.011

• Maruyama T, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H and Ichijo H

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

The EMBO Journal. 2010 Aug 4;29(15):2501-14.

doi: 10.1038/emboj.2010.141

• Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H and Ichijo H

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

Biochemical and Biophysical Research Communications. 2009 Feb 20;379(4):995-1000.

doi: 10.1016/j.bbrc.2008.12.182

• Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K and Ichijo H

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

Genes & Development. 2008 Jun 1;22(11):1451-64.  

doi: 10.1101/gad.1640108

2. 総説