Laboratory of Molecular Genetics

1. Yujin Kwak, Soyoun Yang, Minju Yuk, Kwangyeon Oh, Changgyu Lee, Taehyun Lee, Hyun Jeong Kim, Boyoung Kim, Minseo Kang, Hanseul Park, Ji Min Han, Kyung Eun Lee, Zhaoming Wang, Nan Song. Genome-wide association study of frailty and integrative functional analysis to elucidate its relationship with aging. Geroscience. 2026 Feb 24. doi: 10.1007/s11357-026-02154-6. IF5.4, 13%

2. Hyeon Joo Ham#, Seung Sik Park, Yong Sun Lee, Tae Hun Kim, Dong Ju Son, Ji-Hun Kim, Key-Hwan Lim, Hanseul Park, Hye Jin Lee, Jaesuk Yun, Sang-Bae Han, Min Ki Choi*, Jin Tae Hong*. CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice. Front. Mol. Neurosci., 07 January 2026. https://doi.org/10.3389/fnmol.2025.1728279. IF3.8, 30%

3. Junhang Park#, Boyoung Kim#, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon-Seok Roh, Key-Hwan Lim, Jin Tae Hong, Sang-Bae Han, Chun-Woong Park*, Seok-Beom Yong*, Hanseul Park*. CRISPRa Lipid Nanocomplex-Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid-βin an Alzheimer’s Disease Mouse Model. Advanced Science. 2026 Jan;13(4):e03725. doi: 10.1002/advs.202503725. Epub 2025 Dec 12.  IF 14.1. 7.1% 한빛사★ 

1. Yu JE#, Shim JH#, Yeo IJ, Son DJ, Yun J, Lim KH, Park H, Roh YS, Han SB, Hong JT*. CHI3L1 promotes cell division through activation of RhoA in lung cancer cells. Cell Commun Signal. 2025 Dec 17. doi: 10.1186/s12964-025-02601-5. IF 8.9, 15%

2. Boyoung Kim, Minju Yuk, Moonsu Park, Hongji Ryu, Junhang Park, Hyerin Yu, Sungsoo Park, Jin Tae Hong, Key-Hwan Lim, Sang-Bae Han, Nan Song, Hanseul Park*. CRISPR-mediated direct targeting of miRNA-33 rescues ApoE lipidation and amyloid-beta metabolism in ApoE4 sporadic Alzheimer’s disease. Brain. 2025 Nov 25:awaf244. doi: 10.1093/brain/awaf244. IF12. 2% 한빛사★ 

3. Kwangyeon Oh, Dabin Yun, Soyoun Yang, Minju Yuk, Changgyu Lee, Boyoung Kim, Suyeon Heo, Qian Dong, Zhaoming Wang, Hanseul Park, Nan Song. A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration. Geroscience. 2025 Sep 15. doi: 10.1007/s11357-025-01885-2. IF 5.4. 13%

4. Boyoung Kim#, Seongju Lee#, Yubyeol Jeon, Hanseul Park*. CRISPR/Cas-based genome editing technology in animal models of human disease: mechanisms, advances, and prospects. JARB. 2025. 2025; 40(3): 109-119. https://doi.org/10.12750/JARB.40.3.109

5. Gahye Moon, Nodir Rustamov, Junhang Park, Hanseul Park, Kumju Park, Eun Hye Choi, and Yoon-Seok Roh. Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study. Nutrients. 2025. 17(5), 914; https://doi.org/10.3390/nu17050914. IF 4.8. 15.4%

1. Moonsu Park#, Hongji Ryu#, Suyeon Heo, Boyoung Kim, Junhang Park, Key-Hwan Lim, Sang-Bae Han, Hanseul Park*. Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer’s disease mouse model. Theranostics. 2025. 15(2):428-438. doi:10.7150/thno.103455 IF12.4, 4% 한빛사★ 

2. Hong Kyung Lee, Hwa Kyung Kim, Ji Yeon Kim, Ji Su Kim, JinKyung Park, Min Sung Kim, Tae Yong Lee, Key-Hwan Lim, Hanseul Park, Dong Ju Son, Jin Tae Hong, Sang-Bae Han. Ingenol-3-Angelate Enhances the B Cell Inhibitory Potential of Mesenchymal Stem Cells, Leading to Marked Alleviation of Lupus Symptoms in MRL.faslpr Mice. Int. J. Mol. Sci. 2024, 25(23), 12625; https://doi.org/10.3390/ijms252312625. IF 4.9, 20%

3. Areeg Almubarak#, Eunji Kim, Il-Jeoung Yu, Hanseul Park*, Yubyeol Jeon*. The Effect of κ-Carrageenan on Porcine Sperm Cryo-Survival. Animals. 2024. May 06; 14(9), 1387; https://doi.org/10.3390/ani14091387. IF3, 8.7%

1. Hanseul Park#, Byounggook Cho#, Hongwon Kim#, Takashi Saito, Takaomi C Saido, Kyoung-Jae Won, Jongpil Kim. Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature Communications. 2023 Feb 13;14(1):802. doi: 10.1038/s41467-023-36519-8. IF17.694, 7.432% 한빛사★

2. Boyoung Kim#, Ji Eun Yu#, In Jun Yeo, Dong Ju Son, Hee Pom Lee, Yoon Seok Roh, Key-Hwan Lim, Jaesuk Yun, Hanseul Park, Sang Bae Han, Jin Tae Hong. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol alleviates inflammatory responses in LPS-induced mice liver sepsis through inhibition of STAT3 phosphorylation. International immunopharmacology. IF5.6, 16.1%

1.  Hanseul Park#, Jaein Shin#, Yunkyung Kim, Takashi Saito, Takaomi C Saido, Jongpil Kim. CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease. Translational Neurodegeneration. 2022 Sep 15;11(1):41. doi: 10.1186/s40035-022-00314-0. IF12.6, 4.6% ★

2. Hongwon Kim#, Byounggook Cho#, Hanseul Park#, Junyeop Kim, Siyoung Kim, Jaein Shin, Christopher J Lengner, Kyoung-Jae Won, Jongpil Kim. Dormant state of quiescent neural stem cells links Shank3 mutation to autism development. Molecular Psychiatry. 2022 Jun;27(6):2751-2765. doi: 10.1038/s41380-022-01563-1. Epub 2022 Apr 20. IF13.437, 4.545% 한빛사★

3. Hanseul Park, Jongpil Kim. Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model. Journal of Pineal Research. 2022 Apr;72(3):e12787. doi: 10.1111/jpi.12787. IF12.081, 3.086% 한빛사★

4. Hanseul Park, Dongyoon Kim, Byounggook Cho, Junho Byun, Yong Sook Kim, Youngkeun Ahn, Jin Hur, Yu-Kyoung Oh, Jongpil Kim. In vivo therapeutic genome editing via CRISPR/Cas9 magnetoplexes for myocardial infarction. Biomaterials. 2022 Feb;281:121327. doi: 10.1016/j.biomaterials.2021.121327. Epub 2021 Dec 20. IF15.863, 2.551% 한빛사★

1. Hanseul Park, Yerim Hwang, Jongpil Kim. Transcriptional activation with Cas9 activator nanocomplexes rescues Alzheimer's disease pathology. Biomaterials. 2021 Dec;279:121229. doi: 10.1016/j.biomaterials.2021.121229. Epub 2021 Oct 27. IF15.863, 2.551% 한빛사★

1. Hanseul Park, Byounggook Cho, Jongpil Kim. Rad50 mediates DNA demethylation to establish pluripotent reprogramming. Experimental and Molecular Medicine. 2020 Jul;52(7):1116-1127. doi: 10.1038/s12276-020-0467-0. Epub 2020 Jul 14.  IF12.172, 6.902% ★

2.  Yujung Chang, Junyeop Kim, Hanseul Park, Hwan Choi, Jongpil Kim. Modelling neurodegenerative diseases with 3D brain organoids. Biological Review. 2020 Oct;95(5):1497-1509. doi: 10.1111/brv.12626. IF14.355, 0.532% ★

3. Hanseul Park, Jaein Shin, Hwan Choi, Byounggook Cho, Jongpil Kim. Valproic Acid Significantly Improves CRISPR/Cas9-Mediated Gene Editing. Cells. 2020 Jun 10;9(6):1447. doi:10.3390/ cells9061447. IF7.666, 25.897% 

1. Choon-Soo Lee, Hyun-Jai Cho, Jin-Woo Lee, Jaewon Lee, Yoo-Wook Kwon, Taekwon Son, Hanseul Park, Jongpil Kim, Hyo-Soo Kim. Identification of Latrophilin-2 as a Novel Cell-Surface Marker for the Cardiomyogenic Lineage and Its Functional Significance in Heart Development. Circulation. 2019 Jun 18;139(25):2910-2912. doi: 10.1161/CIRCULATIONAHA.119.040826. Epub 2019 Jun 17. IF39.922, 0.746% 한빛사★

2.  Hanseul Park, Jungju Oh, Gayong Shim, Byounggook Cho, Yujung Chang, Siyoung Kim, Soonbong Baek, Hongwon Kim, Jeain Shin, Hwan Choi, Junsang Yoo, Junyeop Kim, Won Jun, Minhyung Lee, Christopher J Lengner, Yu-Kyoung Oh, Jongpil Kim. In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease. Nature Neuroscience. 2019 Apr;22(4):524-528. doi: 10.1038/s41593-019-0352-0. Epub 2019 Mar 11. IF28.771, 0.545% 한빛사★

3. Hongwon Kim, Hyeok Ju Park, Hwan Choi, Yujung Chang, Hanseul Park, Jaein Shin, Junyeop Kim, Christopher J Lengner, Yong Kyu Lee, Jongpil Kim. Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids. Stem Cell Reports. 2019 Mar 5;12(3):518-531. doi:10.1016/

j.stemcr.2019.01.020. Epub 2019 Feb 21. IF7.294, 25.862%

4. Soonbong Baek, Hwan Choi, Hanseul Park, Byunguk Cho, Siyoung Kim, Jongpil Kim. Effects of a hypomagnetic field on DNA methylation during the differentiation of embryonic stem cells. Scientific reports. 2019 Feb 4;9(1):1333. doi: 10.1038/s41598-018-37372-2. IF4.997, 25%

1. Jaein Shin, Junyeop Kim, Hanseul Park, Jongpil Kim. Investigating the role of Sirtuins in cell reprogramming. BMB Reports. 2018 Oct;51(10):500-507. doi: 10.5483/BMBRep.2018.51.10.172. IF5.041, 36.195% 

2. Yu-Kang Kim, Ah-Reum Lee, Hanseul Park, Junsang Yoo, Sora Ahn, Song-Hee Jeon, Jongpil Kim, Hi-Joon Park. Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. Molecular Neurobiology. 2019 Apr;56(4):2408-2423. doi: 10.1007/s12035-018-1194-6. Epub 2018 Jul 20. IF5.686, 24.909%

3. Soonbong Baek, Jaesur Oh, Juhyun Song, Hwan Choi, Junsang Yoo, Gui-Yeon Park, Jin Han, Yujung Chang, Hanseul Park, Hongwon Kim, Ssang-Goo Cho, Byung-Soo Kim, Jongpil Kim. Generation of Integration-Free Induced Neurons Using Graphene Oxide-Polyethylenimine. Small. 2017 Feb;13(5). doi: 10.1002/smll.201601993. Epub 2016 Nov 7. IF15.153, 6.522% ★

4. Hanseul Park, Hongwon Kim, Junsang Yoo, Jaekwang Lee, Hwan Choi, Soonbong Baek, C Justin Lee, Janghwan Kim, Christopher J Lengner, Jung-Suk Sung, Jongpil Kim. Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system. Biomaterials. 2015 Dec;72:152-62. doi: 10.1016/j.biomaterials.2015.09.002. Epub 2015 Sep 6. IF15.863, 2.551% ★

5. A-Na Ha#, Han-Seul Park#, Jong-In Jin, Sang-Ho Lee, Dae-Hwan Ko, Dong-Suk Lee, Kenneth L White, Il-Keun Kong. Postthaw survival of in vitro-produced bovine blastocysts loaded onto the inner surface of a plastic vitrification straw. Theriogenology. 2014 Feb;81(3):467-73. doi: 10.1016/j.theriogenology.2013.10.024. Epub 2013 Nov 5. IF2.923, 14.138%

6. A-Na Ha, Sang-Ryeul Lee, Jeong-Seon Jeon, Han-Seul Park, Sang-Ho Lee, Jong-In Jin, Benjamin R Sessions, Zhongde Wang, Kenneth L White, Il-Keun Kong. Development of a modified straw method for vitrification of in vitro-produced bovine blastocysts and various genes expression in between the methods. Cryobiology. 2014 Feb;68(1):57-64. doi: 10.1016/j.cryobiol.2013.11.007. Epub 2013 Nov 25. IF2.728, 52.66%