Laboratory of Molecular Genetics

1. Hyeon Joo Ham#, Seung Sik Park, Yong Sun Lee, Tae Hun Kim, Dong Ju Son, Ji-Hun Kim, Key-Hwan Lim, Hanseul Park, Hye Jin Lee, Jaesuk Yun, Sang-Bae Han, Min Ki Choi*, Jin Tae Hong*. CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice. Front. Mol. Neurosci., 07 January 2026. https://doi.org/10.3389/fnmol.2025.1728279. IF3.8, 30%

1. Yu JE#, Shim JH#, Yeo IJ, Son DJ, Yun J, Lim KH, Park H, Roh YS, Han SB, Hong JT*. CHI3L1 promotes cell division through activation of RhoA in lung cancer cells. Cell Commun Signal. 2025 Dec 17. doi: 10.1186/s12964-025-02601-5. IF 8.9, 15%

2. Junhang Park#, Boyoung Kim#, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon-Seok Roh, Key-Hwan Lim, Jin Tae Hong, Sang-Bae Han, Chun-Woong Park*, Seok-Beom Yong*, Hanseul Park*. CRISPRa Lipid Nanocomplex-Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid-βin an Alzheimer’s Disease Mouse Model. Advanced Science. 2025 Dec 12:e03725. doi: 10.1002/advs.202503725. IF 14.1. 7.1% 한빛사★ 

3. Boyoung Kim, Minju Yuk, Moonsu Park, Hongji Ryu, Junhang Park, Hyerin Yu, Sungsoo Park, Jin Tae Hong, Key-Hwan Lim, Sang-Bae Han, Nan Song, Hanseul Park*. CRISPR-mediated direct targeting of miRNA-33 rescues ApoE lipidation and amyloid-beta metabolism in ApoE4 sporadic Alzheimer’s disease. Brain. 2025 Nov 25:awaf244. doi: 10.1093/brain/awaf244. IF12. 2% 한빛사★ 

4. Kwangyeon Oh, Dabin Yun, Soyoun Yang, Minju Yuk, Changgyu Lee, Boyoung Kim, Suyeon Heo, Qian Dong, Zhaoming Wang, Hanseul Park, Nan Song. A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration. Geroscience. 2025 Sep 15. doi: 10.1007/s11357-025-01885-2. IF 5.4. 13%

5. Boyoung Kim#, Seongju Lee#, Yubyeol Jeon, Hanseul Park*. CRISPR/Cas-based genome editing technology in animal models of human disease: mechanisms, advances, and prospects. JARB. 2025. 2025; 40(3): 109-119. https://doi.org/10.12750/JARB.40.3.109

6. Gahye Moon, Nodir Rustamov, Junhang Park, Hanseul Park, Kumju Park, Eun Hye Choi, and Yoon-Seok Roh. Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study. Nutrients. 2025. 17(5), 914; https://doi.org/10.3390/nu17050914. IF 4.8. 15.4%

1. Moonsu Park#, Hongji Ryu#, Suyeon Heo, Boyoung Kim, Junhang Park, Key-Hwan Lim, Sang-Bae Han, Hanseul Park*. Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer’s disease mouse model. Theranostics. 2025. 15(2):428-438. doi:10.7150/thno.103455 IF12.4, 4% 한빛사★ 

2. Hong Kyung Lee, Hwa Kyung Kim, Ji Yeon Kim, Ji Su Kim, JinKyung Park, Min Sung Kim, Tae Yong Lee, Key-Hwan Lim, Hanseul Park, Dong Ju Son, Jin Tae Hong, Sang-Bae Han. Ingenol-3-Angelate Enhances the B Cell Inhibitory Potential of Mesenchymal Stem Cells, Leading to Marked Alleviation of Lupus Symptoms in MRL.faslpr Mice. Int. J. Mol. Sci. 2024, 25(23), 12625; https://doi.org/10.3390/ijms252312625. IF 4.9, 20%

3. Areeg Almubarak#, Eunji Kim, Il-Jeoung Yu, Hanseul Park*, Yubyeol Jeon*. The Effect of κ-Carrageenan on Porcine Sperm Cryo-Survival. Animals. 2024. May 06; 14(9), 1387; https://doi.org/10.3390/ani14091387. IF3, 8.7%

1. Hanseul Park#, Byounggook Cho#, Hongwon Kim#, Takashi Saito, Takaomi C Saido, Kyoung-Jae Won, Jongpil Kim. Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature Communications. 2023 Feb 13;14(1):802. doi: 10.1038/s41467-023-36519-8. IF17.694, 7.432% 한빛사★

2. Boyoung Kim#, Ji Eun Yu#, In Jun Yeo, Dong Ju Son, Hee Pom Lee, Yoon Seok Roh, Key-Hwan Lim, Jaesuk Yun, Hanseul Park, Sang Bae Han, Jin Tae Hong. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol alleviates inflammatory responses in LPS-induced mice liver sepsis through inhibition of STAT3 phosphorylation. International immunopharmacology. IF5.6, 16.1%

1.  Hanseul Park#, Jaein Shin#, Yunkyung Kim, Takashi Saito, Takaomi C Saido, Jongpil Kim. CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease. Translational Neurodegeneration. 2022 Sep 15;11(1):41. doi: 10.1186/s40035-022-00314-0. IF12.6, 4.6% ★

2. Hongwon Kim#, Byounggook Cho#, Hanseul Park#, Junyeop Kim, Siyoung Kim, Jaein Shin, Christopher J Lengner, Kyoung-Jae Won, Jongpil Kim. Dormant state of quiescent neural stem cells links Shank3 mutation to autism development. Molecular Psychiatry. 2022 Jun;27(6):2751-2765. doi: 10.1038/s41380-022-01563-1. Epub 2022 Apr 20. IF13.437, 4.545% 한빛사★

3. Hanseul Park, Jongpil Kim. Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model. Journal of Pineal Research. 2022 Apr;72(3):e12787. doi: 10.1111/jpi.12787. IF12.081, 3.086% 한빛사★

4. Hanseul Park, Dongyoon Kim, Byounggook Cho, Junho Byun, Yong Sook Kim, Youngkeun Ahn, Jin Hur, Yu-Kyoung Oh, Jongpil Kim. In vivo therapeutic genome editing via CRISPR/Cas9 magnetoplexes for myocardial infarction. Biomaterials. 2022 Feb;281:121327. doi: 10.1016/j.biomaterials.2021.121327. Epub 2021 Dec 20. IF15.863, 2.551% 한빛사★

1. Hanseul Park, Yerim Hwang, Jongpil Kim. Transcriptional activation with Cas9 activator nanocomplexes rescues Alzheimer's disease pathology. Biomaterials. 2021 Dec;279:121229. doi: 10.1016/j.biomaterials.2021.121229. Epub 2021 Oct 27. IF15.863, 2.551% 한빛사★

1. Hanseul Park, Byounggook Cho, Jongpil Kim. Rad50 mediates DNA demethylation to establish pluripotent reprogramming. Experimental and Molecular Medicine. 2020 Jul;52(7):1116-1127. doi: 10.1038/s12276-020-0467-0. Epub 2020 Jul 14.  IF12.172, 6.902% ★

2.  Yujung Chang, Junyeop Kim, Hanseul Park, Hwan Choi, Jongpil Kim. Modelling neurodegenerative diseases with 3D brain organoids. Biological Review. 2020 Oct;95(5):1497-1509. doi: 10.1111/brv.12626. IF14.355, 0.532% ★

3. Hanseul Park, Jaein Shin, Hwan Choi, Byounggook Cho, Jongpil Kim. Valproic Acid Significantly Improves CRISPR/Cas9-Mediated Gene Editing. Cells. 2020 Jun 10;9(6):1447. doi:10.3390/ cells9061447. IF7.666, 25.897% 

1. Choon-Soo Lee, Hyun-Jai Cho, Jin-Woo Lee, Jaewon Lee, Yoo-Wook Kwon, Taekwon Son, Hanseul Park, Jongpil Kim, Hyo-Soo Kim. Identification of Latrophilin-2 as a Novel Cell-Surface Marker for the Cardiomyogenic Lineage and Its Functional Significance in Heart Development. Circulation. 2019 Jun 18;139(25):2910-2912. doi: 10.1161/CIRCULATIONAHA.119.040826. Epub 2019 Jun 17. IF39.922, 0.746% 한빛사★

2.  Hanseul Park, Jungju Oh, Gayong Shim, Byounggook Cho, Yujung Chang, Siyoung Kim, Soonbong Baek, Hongwon Kim, Jeain Shin, Hwan Choi, Junsang Yoo, Junyeop Kim, Won Jun, Minhyung Lee, Christopher J Lengner, Yu-Kyoung Oh, Jongpil Kim. In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease. Nature Neuroscience. 2019 Apr;22(4):524-528. doi: 10.1038/s41593-019-0352-0. Epub 2019 Mar 11. IF28.771, 0.545% 한빛사★

3. Hongwon Kim, Hyeok Ju Park, Hwan Choi, Yujung Chang, Hanseul Park, Jaein Shin, Junyeop Kim, Christopher J Lengner, Yong Kyu Lee, Jongpil Kim. Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids. Stem Cell Reports. 2019 Mar 5;12(3):518-531. doi:10.1016/

j.stemcr.2019.01.020. Epub 2019 Feb 21. IF7.294, 25.862%

4. Soonbong Baek, Hwan Choi, Hanseul Park, Byunguk Cho, Siyoung Kim, Jongpil Kim. Effects of a hypomagnetic field on DNA methylation during the differentiation of embryonic stem cells. Scientific reports. 2019 Feb 4;9(1):1333. doi: 10.1038/s41598-018-37372-2. IF4.997, 25%

1. Jaein Shin, Junyeop Kim, Hanseul Park, Jongpil Kim. Investigating the role of Sirtuins in cell reprogramming. BMB Reports. 2018 Oct;51(10):500-507. doi: 10.5483/BMBRep.2018.51.10.172. IF5.041, 36.195% 

2. Yu-Kang Kim, Ah-Reum Lee, Hanseul Park, Junsang Yoo, Sora Ahn, Song-Hee Jeon, Jongpil Kim, Hi-Joon Park. Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. Molecular Neurobiology. 2019 Apr;56(4):2408-2423. doi: 10.1007/s12035-018-1194-6. Epub 2018 Jul 20. IF5.686, 24.909%

3. Soonbong Baek, Jaesur Oh, Juhyun Song, Hwan Choi, Junsang Yoo, Gui-Yeon Park, Jin Han, Yujung Chang, Hanseul Park, Hongwon Kim, Ssang-Goo Cho, Byung-Soo Kim, Jongpil Kim. Generation of Integration-Free Induced Neurons Using Graphene Oxide-Polyethylenimine. Small. 2017 Feb;13(5). doi: 10.1002/smll.201601993. Epub 2016 Nov 7. IF15.153, 6.522% ★

4. Hanseul Park, Hongwon Kim, Junsang Yoo, Jaekwang Lee, Hwan Choi, Soonbong Baek, C Justin Lee, Janghwan Kim, Christopher J Lengner, Jung-Suk Sung, Jongpil Kim. Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system. Biomaterials. 2015 Dec;72:152-62. doi: 10.1016/j.biomaterials.2015.09.002. Epub 2015 Sep 6. IF15.863, 2.551% ★

5. A-Na Ha#, Han-Seul Park#, Jong-In Jin, Sang-Ho Lee, Dae-Hwan Ko, Dong-Suk Lee, Kenneth L White, Il-Keun Kong. Postthaw survival of in vitro-produced bovine blastocysts loaded onto the inner surface of a plastic vitrification straw. Theriogenology. 2014 Feb;81(3):467-73. doi: 10.1016/j.theriogenology.2013.10.024. Epub 2013 Nov 5. IF2.923, 14.138%

6. A-Na Ha, Sang-Ryeul Lee, Jeong-Seon Jeon, Han-Seul Park, Sang-Ho Lee, Jong-In Jin, Benjamin R Sessions, Zhongde Wang, Kenneth L White, Il-Keun Kong. Development of a modified straw method for vitrification of in vitro-produced bovine blastocysts and various genes expression in between the methods. Cryobiology. 2014 Feb;68(1):57-64. doi: 10.1016/j.cryobiol.2013.11.007. Epub 2013 Nov 25. IF2.728, 52.66%