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Dr. Niall Howlett
Dr. Niall Howlett
Dr. Howlett is an associate professor at the University of Rhode Island. His lab focuses on studying the pathology of Fanconi anemia, and looking into the eukaryotic cellular DNA damage response.
Fanconi anemia (FA) is an extremely rare DNA repair genetic disease that is inherited from generation to generation (FA is both an autosomal and X-linked disease). This disease causes major bone marrow failure and can cause malformations throughout the body. FA can also cause increased susceptibility to leukemia and other forms of cancer. The average life expectancy with FA is ~20-30 years. More research on FA can help increase the treatments of the condition, as therapeutics at this point are extremely limited.
Dr. Howlett's lab has several interests and focus areas, including,
Regulation of the Mono-Ubiquitination of the FANCD2 protein
Understanding the Role of the FA-BRCA Pathway in the Suppression of Genomic Structural Variation
Chromatin Dynamics and DNA Interstrand Crosslink (ICL) Repair
PTEN and DNA Interstrand Crosslink (ICL) Repair
Students interested in Dr. Howlett's lab are encouraged to contact him at nhowlett@uri.edu
For more information on Dr. Howlett's lab and research findings, please visit his lab website https://web.uri.edu/howlett/
Dr. Niall Howlett
2001-2003 Research Fellow in Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
1998-2001 Research Fellow in Cancer Cell Biology, Harvard School of Public Health, Boston, MA
Ph.D. (1999) Biological & Molecular Sciences, Oxford Brookes University, Oxford, U.K.
B.Sc. (1994) Industrial Biochemistry, University of Limerick, Limerick, Ireland
Courses
BCH311: Introductory Biochemistry
BCH435: Introduction to the Biology and Genetics of Cancer
MIC521: Recent Advances in Cell and Molecular Biology
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